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| 1 | Host genetic factors affecting hepatitis B infection outcomes:Insights from genome-wide association studies显示文摘The clinical outcome of hepatitis B virus(HBV) infection depends on the success or failure of the immune responses to HBV,and varies widely among individuals,ranging from asymptomatic self-limited infection,inactive carrier state,chronic hepatitis,cirrhosis,hepatocellular carcinoma,to liver failure,depending on the success or failure of immune response to HBV.Genome-wide association studies(GWAS) identified key genetic factors influencing the pathogenesis of HBV-related traits.In this review,we discuss GWAS for persistence of HBV infection,antibody response to hepatitis B vaccine,and HBV-related advanced liver diseases.HBV persistence is associated with multiple genes with diverse roles in immune mechanisms.The strongest associations are found within the classical human leukocyte antigen(HLA) genes,highlighting the central role of antigen presentation in the immune response to HBV.Associated variants affect both epitope binding specificities and expression levels of HLA molecules.Several other susceptibility genes regulate the magnitude of adaptive immune responses,determining immunity vs tolerance.HBV persistence and nonresponse to vaccine share the same risk variants,implying overlapping genetic bases.On the other hand,the risk variants for HBV-related advanced liver diseases are largely different,suggesting different host-virus dynamics in acute vs chronic HBV infections.The findings of these GWAS are likely to pave the way for developing more effective preventive and therapeutic interventions by personalizing the management of HBV infection. | Izzet Mehmet Akcay Seyma Katrinli Kamil Ozdil Gizem Dinler Doganay Levent Doganay | 2018 | World Journal of Gastroenterology2018，24，30： | 6 |
| 2 | Anti-pancreatic antibody in Turkish patients with inflammatory bowel disease and first-degree relatives显示文摘AIM: To identify the role of anti-pancreatic antibody (PAB) in the diagnosis of inflammatory bowel diseases (IBD) among Turkish patients, and its frequency in firstdegree relatives.METHODS: PAB and anti-Saccharomyces cerevisiae (ASCA) were examined in serum samples of 214 subjects including patients with Crohn's disease (CD, n = 64), ulcerative colitis (UC, n = 63), first-degree relatives of patients with CD (n = 25), first-degree relatives of patients with UC (n = 28),and a control group with gastrointestinal symptoms other than (IBD) (n = 34) by indirect immunofluorescence Positivity of PAB and ASCA was compared in terms of Vienna classification, disease activity and medications used.RESULTS: In terms of PAB positivity, no difference was found between patients with CD (14.1%) and UC (7.9%) however, significant difference was observed between patients with CD and subjects in the control group (P < 0.05). No difference was found between patients with CD and their relatives in terms of ASCA positivity, whereas a significant difference was found between other groups (P < 0.001). Compared to ASCA, the sensitivity of the PAB was 19% (7/37), its specificity was 93% (25/27), positive predictive value was 77% (7/9) and negative predictive value was 45% (25/55). ASCA was found with significantly higher prevalence in patients with CD activity index > 150 (P < 0.05).CONCLUSION: PAB is valuable in the diagnosis of IBD rather than CD, but cannot be used alone for diagnostic purposes. PAB is not superior to ASCA in CD diagnosis and in detecting CD among relatives of patients with CD. | Huseyin Demirsoy Kamil Ozdil Ozdal Ersoy Besir Kesici Cetin Karaca Canan Alkim Nihat Akbayir Levent Kamil Erdem Mehmet Derya Onuk Hulya Tugrul Beyzadeoglu | 2010 | World Journal of Gastroenterology2010，16，45： | 3 |
| 3 | What is the reason of elevated alanine amino- transferase level in HBeAg negative pati- ents with low viremia: NAFLD or chronic hepatitis显示文摘 | Demir K Akyuz F Ozdil S | 2007 | Ann Hepatol2007，6，2： | 1 |
| 4 | Extracorporeal shockwave litho- tripsy in anomalous kidneys 显示文摘 | Baltaci S Sarica K Ozdiler E | 1994 | J Endourol1994，8，3： | 1 |
| 5 | What is the reason of elevated alanine Aminotransferase level in HBeAg negative patients with low viremia: NAFLD or chronic hepatitis显示文摘 | Demir K Akyuz F Ozdil S | 2007 | Arm Hepatol2007，6，2： | 1 |
| 6 | Panoramic radiographs:a tool for investigating skeletal pattern显示文摘 | Akcam MO Altiok T Ozdiler E | 2003 | Am J Orthod Dentofacial Orthop2003，123，2： | 1 |
| 7 | Acute promyelocytie leukemia treated with idarubicin complicated by focal segmental glomerulosclerosis显示文摘 | Bari S Ozdil M Topal N | 2010 | J Pediatr Hematol Oncol2010，32，： | 1 |
| 8 | Massive Lower Gastrointestinal Hemorrhage Secondary to Rectal Hemorrhoids in Elderly Patients Receiving Anticoagulant Therapy: Case Series显示文摘 | Burhan Ozdil Hikmet Akkiz Macit Sandikci Can Kece Arif Cosar | 2010 | Digestive Diseases and Sciences2010，，9： | 1 |
| 9 | The effect of laparoscopic cho- lecystectomy on the development of alkaline reflux gastritis and intestinal metaplasia显示文摘 | A tak I Ozdil K Y cel M | 2012 | Hepatogastroenterology2012，113，59： | 1 |
| 10 | Association of the MEFV Gene Variations With Inflammatory Bowel Disease in Turkey显示文摘 | Filiz Akyuz Fatih Besisik Duran Ustek Cumhur Ekmek?i Aytul Uyar Binnur Pinarbasi Kadir Demir Sadakat Ozdil Sabahattin Kaymakoglu Gungor Boztas Zeynel Mungan Ahmet Gul | 2013 | Journal of Clinical Gastroenterology2013，，3： | 1 |
| 11 | A rare cause of ischemic stroke : fibromuscular dysplasia显示文摘 | Ozdil M Baris S Ozyilmaz I Dogru O Celkan T Albayram S | 2009 | Neurol Sci2009，30，1： | 1 |
| 12 | Panoramic radiographs:A tool for investigating skeletal pattern显示文摘 | Akcam MO Altiok T Ozdiler E | 2003 | Am J Orthod Dentofacial Orthop2003，123，2： | 1 |
| 13 | Craniofacial growth and skeletal maturation:a mixed longitudinal study显示文摘 | Arat M Koklu A Ozdiler E | 2001 | Eur J Orthod2001，23，4： | 1 |
| 14 | Negative correlation between viral load and HBsAg levels in chronic HBVoinfected patients显示文摘 | Ozdil B Cosar AM Akkiz H | 2009 | Arch Viol2009，154，9： | 1 |
| 15 | Pneumatic balloon dilation in primary achalasia: the long-term follow up results 显示文摘 | Boztas G Mungan Z Ozdil S | 2005 | Hepatogastroenterology2005，52，6： | 1 |
| 16 | Third molar impaction in extraction cases treated with the Begg technique显示文摘 | Erdem D Ozdiler E Toygar Memikoglu U | | 0，，03： | 1 |
| 17 | The diagnostic value of endoscopic balloon catheter usage for detecting early-stage primary sclerosing cholangitis in endoscopic retrograde cholangiopancreatography:a case report显示文摘 | Ozdil B Cosar A Kece C | 2010 | Case Rep Gastroen-terol2010，4，1： | 1 |
| 18 | Panoramic radiographs:A tool for investigating skeletal pattern显示文摘 | Akcam MO Altiok T Ozdiler E | 2003 | Am J Orthod Dentofacial Orthop2003，123，2： | 1 |
| 19 | A comparative study of the characteristics of compact yarn-based Knitted fabrics显示文摘 | OZDIL Nilgun OZDOGAN Esen DEMIREL Alparslani | 2005 | Fibres & Textiles in Eastern Europe2005，13，2： | 1 |
| 20 | Recurrent hyper- splenism caused by giant accessory spleen due to portalhypertension after splenectomia 显示文摘 | Ozdil B Akkiz H Sandikci M | 2010 | Platelets2010，21，1： | 1 |
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