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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Improving hierarchical cluster analysis: a new method with outlier detection and automatic clustering显示文摘 | ALMEIDA J A S BARBOSA L M S PAIS A A C C | 2007 | Chemometrics and Intelligent Labora- tory Systems2007，87，2： | 1 |
| 3 | Iberian Universities: a Characterisation from ESI Ranldngs显示文摘 | Cova T F G G Pais A A C C Formosinho S O J | 2013 | Scientomet- tics2013，94，3： | 1 |
| 4 | Microstructure and mechanical properties of Si and Sb added AZ91 magnesium alloy显示文摘 | SRINIVASAN A PILLAI U T S PAI B C | 2005 | Metallurgical and Materials Transactions A2005，36，8： | 1 |
| 5 | Effects acidity and molybdate concentration on the kinetics of the formation of the phosphoantimonylmolybdenum blue complex显示文摘 | PAI S C YANG C C RILEY J P | 1990 | Analytica Chimica1990，229，： | 1 |
| 6 | Microstructure and mechanical properties of Si and Sb added AZ91 magnesium alloy 显示文摘 | SRINIVASAN A PILLAI U T S PAI B C | 2005 | Metallurgical and Materials Transactions A2005，36，8： | 1 |
| 7 | Radiofrequency-assisted hepatic resection显示文摘 | Pai M Kyriakides C Mikhail S | 2011 | Ann Surg Oncol2011，18，12： | 1 |
| 8 | critical roles for transcription factor GATA-3 in thymocyte development显示文摘 | Pai S Y Truitt M L Ting C N | | 0，，： | 1 |
| 9 | 显示文摘 | Hwang T L Pai Y M Liu C S | 1980 | J Am Chem Soc1980，102，25： | 1 |
| 10 | Potential applications of aerobic denitrifiying bacteria as bio-agents in waste water treatment显示文摘 | Pai S L Chong N M Chen C H | 1999 | Bioresource Technology1999，68，2： | 1 |
| 11 | J Catal显示文摘 | Kumar S B Mirajkar S P Pais G C G Kumar P Kumar R | 1995 | 156:1631995，156，： | 1 |
| 12 | Potential applications of aerobic denitrifiying bacteria as bioagents In waste water treatment显示文摘 | Pai S L Chong N M Chen C H | | 0，，02： | 1 |
| 13 | Improving hierarchical cluster analysis: A new method with outlier detection and automatic clustering显示文摘 | ALMEIDA J A S BARBOSA L M S PAIS A A C C | 2007 | Chemometrics and Intelligent Laboratory Systems2007，87，： | 1 |
| 14 | Optimization of heat treatment parameters in ZA84 magnesium alloy 显示文摘 | BALASUBRAMANI N PILLAI U T S PAI B C | 2008 | J Alloys Comp2008，457，12： | 1 |
| 15 | Safety and antitumor activity of recombinant soluble Apo2 ligand显示文摘 | Ashkenazi A Pai R C Fong S | 1999 | Journal of Clinical Investigation1999，104，： | 1 |
| 16 | Optimization of heat treatment parameters in ZA84 magnesium alloy显示文摘 | BALASUBRAMANI N PILLAI U T S PAI B C | 2008 | J Alloys Compd2008，457，： | 1 |
| 17 | Homogeneneous Catalytic Hydroformylation of Vinylarenes:A Selective Rhodium Diphosphine Catalyst System for Highter Branched/Linear Product Ratios显示文摘 | CHAN A S C PAI C C YANG T K CHEN S-M | 1995 | J Chem Soc Chem Commun1995，，： | 1 |
| 18 | Education and cognitive decline in Parkinson's disease: a study of 102 patients显示文摘 | Pai M C Chart S H | 2001 | Acta Neurol Scand2001，103，4： | 1 |
| 19 | Exchange of water masses between the East China Sea and the Kuroshio off northeastern Taiwan 显示文摘 | CHEN C T A RUO R PAI S C | 1995 | Continental Shelf Research1995，15，1： | 1 |
| 20 | Critical roles for transcrip- tion factor GATA in thymoeyte development 显示文摘 | Pai S Y Truitt M L Ting C N | 2003 | Immunity2003，19，6： | 1 |
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