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您的检索式：作者名="PANG Mengting"
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| 1 | Impact of Poly(Ester Amide) Structure on Properties and Drug Delivery for Prostate Cancer Therapy显示文摘Objective:We aim to develop a polymer library consisting of phenylalanine-based poly(ester amide)s(Phe-PEAs)for cancer therapy and investigate the structure–property relationship of these polymers to understand their impact on the drug delivery efficiency of corresponding nanoparticles(NPs).Impact Statement:Our study provides insights into the structure–property relationship of polymers in NP-based drug delivery applications and offers a potential polymer library and NP platform for enhancing cancer therapy.Introduction:Polymer NP-based drug delivery systems have demonstrated substantial potential in cancer therapy by improving drug efficacy and minimizing systemic toxicity.However,successful design and optimization of these systems require a comprehensive understanding of the relationship between polymer structure and physicochemical properties,which directly influence the drug delivery efficiency of the corresponding NPs.Methods:A series of Phe-PEAs with tunable structures was synthesized by varying the length of the methylene group in the diol part of the polymers.Subsequently,Phe-PEAs were formulated into NPs for doxorubicin(DOX)delivery in prostate cancer therapy.Results:Small adjustments in polymer structure induced the changes in the hydrophobicity and thermal properties of the PEAs,consequently NP size,drug loading capacity,cellular uptake efficacy,and cytotoxicity.Additionally,DOXloaded Phe-PEA NPs demonstrated enhanced tumor suppression and reduced side effects in prostate tumor-bearing mice.Conclusion:Phe-PEAs,with their finely tunable structures,show great promise as effective and customizable nanocarriers for cancer therapy. | Junfu Zhang Liying Wang Mengting Ding Xinru You Jun Wu Jun Pang | 2023 | Biomedical Engineering Frontiers2023，4，1： | 0 |
| 2 | High-performance Removal of Tetracycline Enabled by Fe^(0)Nanoparticles Supported on Carbon@ZIF-8显示文摘Significant concerns have been raised over the removal of antibiotics,such as tetracyclines(TC)in aquatic environments.Herein,we synthesized a new type of heterogeneous catalyst by supporting Fe^(0) nanopartciles(FeNPs)onto carbon coated ZIF-8(C@ZIF-8).The carbon layer formed by glucose was beneficial to maintain the morphology and porous structure of ZIF-8,which can also appropriately improve the hydrophobicity of ZIF-8 for enriching the TC.The as-prepared FeNPs-C@ZIF-8 catalyst featured an extreme large specific surface area(1122.16 m2/g),and the supported FeNPs with an average diameter of 6.13 nm exhibited a high dispersity on the supporting matrix of C@ZIF-8.For the removal of tetracycline,the large specific surface area of FeNPs-C@ZIF-8 allowed for an easy access of tetracycline to the FeNPs,while the highly dispersed FeNPs served as actived sites for the efficient degradation of tetracycline.A synergistic effect between adsorption and catalytic degradation of FeNPs(5%,mass fraction)-C@ZIF-8 was proven to be responsible for the high-performance removal of tetracycline with the removal efficiency high up to 93.02%at pH 5,25℃.The FeNPs-C@ZIF-8 was capable of recycling after activation with supplementary Fe^(0),which still maintained a high removal efficiency of 75.52%in the 5th cycle within 20 min. | XIAO Meng QI Wenqian JIA Shuanghui PANG Mengting SHI Fengcheng MAO Hui | 2022 | Chemical Research in Chinese Universities2022，38，6： | 0 |
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