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| 1 | Isolation and characterisation of human gingival margin-derived STRO-1/MACS^+ and MACS^-cell populations显示文摘Recently,gingival margin-derived stem/progenitor cells isolated via STRO-1/magnetic activated cell sorting(MACS) showed remarkable periodontal regenerative potential in vivo.As a second-stage investigation,the present study's aim was to perform in vitro characterisation and comparison of the stem/progenitor cell characteristics of sorted STRO-1-positive(MACS^+) and STRO-1-negative(MACS^-) cell populations from the human free gingival margin.Cells were isolated from the free gingiva using a minimally invasive technique and were magnetically sorted using anti-STRO-1 antibodies.Subsequently,the MACS^+ and MACS^- cell fractions were characterized by flow cytometry for expression of CD14,CD34,CD45,CD73,CD90,CD105,CD146/MUC18 and STRO-1.Colony-forming unit(CFU) and multilineage differentiation potential were assayed for both cell fractions.Mineralisation marker expression was examined using real-time polymerase chain reaction(PCR).MACS^+ and MACS- cell fractions showed plastic adherence.MACS^+ cells,in contrast to MACS- cells,showed all of the predefined mesenchymal stem/progenitor cell characteristics and a significantly higher number of CFUs(P<0.01).More than 95%of MACS^+ cells expressed CD105,CD90 and CD73;lacked the haematopoietic markers CD45,CD34 and CD14,and expressed STRO-1 and CD146/MUC18.MACS- cells showed a different surface marker expression profile,with almost no expression of CD14 or STRO-1,and more than 95%of these cells expressed CD73,CD90 and CD146/MUC18,as well as the haematopoietic markers CD34 and CD45 and CD105.MACS^+ cells could be differentiated along osteoblastic,adipocytic and chondroblastic lineages.In contrast,MACS- cells demonstrated slight osteogenic potential.Unstimulated MACS^+ cells showed significantly higher expression of collagen I(P<0.05) and collagen III(P<0.01),whereas MACS^- cells demonstrated higher expression of osteonectin(P<0.05;MannWhitney).The present study is the first to compare gingival MACS^+ and MACS- cell populations demonstrating that MACS^+ cells,in contrast to MACS- cells,harbour stem/progenitor cell characteristics.This study also validates the effectiveness of the STRO-l/MACS^+technique for the isolation of gingival stem/progenitor cells.Human free gingival margin-derived STRO-1/MACS^+ cells are a unique renewable source of multipotent stem/progenitor cells. | Karim M Fawzy El-Sayed Sebastian Paris Christian Graetz Neemat Kassem Mohamed Mekhemar Hendrick Ungefroren Fred Fndrich Christof Drfer | 2015 | International Journal of Oral Science2015，7，2： | 6 |
| 2 | Comparison of four proton pump inhibitors for the short-term treatment of esophagitis in elderly patients显示文摘AIM: To compare efficacy and tolerability of four proton pump inhibitors (PPIs) commonly used in the short-term therapy of esophagitis in elderly patients.METHODS: A total of 320 patients over 65 years with endoscopically diagnosed esophagitis were randomly assigned to one of the following treatments for 8 wk: (1) omeprazole 20 mg/d; (2) lansoprazole 30 mg/d; (3) pantoprazole 40 mg/d, or (4) rabeprazole 20 mg/d. Major symptoms, compliance, and adverse events were recorded. After 8 wk, endoscopy and clinical evaluation were repeated.RESULTS: Per protocol and intention to treat healing rates of esophagitis were: omeprazole = 81.0% and 75.0%, lansoprazole = 90.7% (P = 0.143 vs omeprazole) and 85.0%, pantoprazole = 93.5% (P = 0.04 vs omeprazole) and 90.0% (P = 0.02 vs omeprazole), rabeprazole = 94.6% (P = 0.02 vs omeprazole) and 88.8% (P = 0.04 vs omeprazole). Dividing patients according to the grades of esophagitis, omeprazole was significantly less effective than the three other PPIs in healing grade 1 esophagitis (healing rates: 81.8% vs 100%, 100% and 100%, respectively, P = 0.012). Pantoprazole and rabeprazole (100%) were more effective vs omeprazole (89.6%, P = 0.0001)and lansoprazole (82.4%, P = 0.0001) in decreasing heartburn. Pantoprazole and rabeprazole (92.2% and 90.1%, respectively) were also more effective vs lansoprazole (75.0%, P < 0.05) in decreasing acid regurgitation. Finally, pantoprazole and rabeprazole (95.2% and 100%) were also more effective vs lansoprazole (82.6%, P < 0.05) in decreasing epigastric pain.CONCLUSION: In elderly patients, pantoprazole and rabeprazole were significantly more effective than omeprazole in healing esophagitis and than omeprazole or lansoprazole in improving symptoms. H pylori infection did not influence the healing rates of esophagitis after a short-term treatment with PPI. | Alberto Pilotto Marilisa Franceschi Gioacchino Leandro Carlo Scarcelli Luigi Piero D'Ambrosio Francesco Paris Vito Annese Davide Seripa Angelo Andriulli Francesco Di Mario | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 3 | Hydroxytryptamine transporter gene-linked polymorphic region(5HTTLPR)is associated with delusions in Alzheimer’s disease显示文摘Background:Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease(AD)have not been fully clarified.5-Hydroxytryptamine transporter gene-linked polymorphic region(5-HTTLPR)is a variable number tandem repeats in the promoter region of serotonin transporter encoding-gene affecting transcription.Methods:We investigated the association of 5-HTTLPR with delusions in a total of 257 consecutive patients clinically diagnosed as AD according to the National Institute on Aging-Alzheimer’s Association criteria.All participants underwent a comprehensive evaluation with a standardized comprehensive geriatric assessment and Neuropsychiatric Inventory.Results:Delusion symptoms were observed in 171 patients(66.54%).In respect to AD patients without delusions,AD patients with delusions showed a low prevalence of S-plus carriers(5-HTTLPR-L/S+5-HTTLPR-S/S genotypes)[p<0.001;odds ratio(OR)=0.240,95% confidence interval(CI)=0.121–0.471].Logistic regression analysis adjusted for the apolipoprotein E polymorphism showed that in AD patients with delusions the presence of an 5-HTTLPR-S allele may reduce disease duration(p=0.005;OR=0.680,95% CI=0.522–0.886)and increase aberrant motor activity(p=0.013;OR=2.257,95% CI=1.195–4.260).The present findings suggested that 5-HTTLPR might be associated with delusions in AD.S-plus carriers might be associated with protective effect against delusions in AD.Conclusions:More studies on wider samples of high selected demented patients are needed to confirm our results.However,the present findings suggested that a genetic factor related to serotonin metabolism might exert a protective role on the clinical expression of neuropsychiatric clusters in AD with important implications regarding mechanisms underlying delusions and their possible treatment across the AD and dementia spectrum. | Grazia D’Onofrio Francesco Panza Daniele Sancarlo Michele Lauriola Mariangela P.Dagostino Giulia Paroni Madia Lozupone Antonio Mangiacotti Paola Bisceglia Carolina Gravina Maria Urbano Filomena Addante Francesco Paris Leandro Cascavilla Antonio Greco Davide Seripa | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 4 | Computer-Aided Radome Analysis显示文摘 | Paris D | | 0，，01： | 2 |
| 5 | Resistive Interchange Mode in the Presence of Equilibrium Flow显示文摘 | HOU L PARIS R B WOOD A D | 1996 | Physics of Plasmas American Institute of Physics1996，3，2： | 1 |
| 6 | Digital computer analysis of aperture antennas显示文摘 | PARIS D T | 1968 | IEEE Trans on Antenna and Propagat1968，16，3： | 1 |
| 7 | Ability of commercially available dairy ration programs to predict duodenal flows of protein and essential amino acids in dairy cows显示文摘 | PACHECO D PATTON R A PARYS C | 2012 | Journal of Dairy Science2012，95，2： | 1 |
| 8 | Digital computer analysis of aperture antennas显示文摘 | Paris D T | 1968 | IEEE Transactions on Antennas and Propagation1968，16，2： | 1 |
| 9 | Computer-aided radome analysis 显示文摘 | PARIS D T | 1970 | IEEE Trans on Antenna and Propagat1970，18，1： | 1 |
| 10 | Overexpression of torsinA in PC12 cells protects against toxicity显示文摘 | Shashidharan P Paris N Sandu D | 2004 | Journalof Neurochemistry2004，88，4： | 1 |
| 11 | Computer-aided radome analysis显示文摘 | Paris D T | 1970 | IEEE Transactions on Antennas and Propagation1970，18，1： | 1 |
| 12 | Selective protein kinase C isoforms are involved in endothelin-1-induced human uterine contraction at the end of pregnancy显示文摘 | Eude I Paris B Cabrol D | 2000 | Biol Reprod2000，63，5： | 1 |
| 13 | Inhibition of Aβ production by NF-κB inhibitors显示文摘 | Paris D Patel N Quadros A | 2007 | Neurosci Lett2007，415，1： | 1 |
| 14 | Anatomic and functional results in 156 cases and are view of the literature 显示文摘 | Paris H Tropiano P Clouet D Fractures of the shaft of the humerus: systematic plate fixation | 2000 | Rev Chir Orthop Reparatrice Appar Mot2000，86，4： | 1 |
| 15 | Estimations on J-integral and tearing modulus T from a single specimen test record显示文摘 | ERNST H A PARIS P C LANDES J D | 1981 | Fracture Mechanics ASTM STP 743 American Society for Testing and Materials1981，1981，： | 1 |
| 16 | Exponentially-improved asymptotics for the gamma function显示文摘 | PARIS R B WOOD A D | 1992 | Comp Appl Math1992，41，： | 1 |
| 17 | Inhibition of angiogenesis and tumor growth by beta and gammasecretase inhibitors显示文摘 | PARIS D QUADROSS A PATEL N | 2005 | Eur J Pharmacol2005，514，1： | 1 |
| 18 | Rating of composite suspension insulators related to the long term mechanical strength of rods显示文摘 | Paris L Pargamin L Dumora D | 1994 | IEEE Transactions on Power Delivery1994，9，4： | 1 |
| 19 | Probe-compensated near-field measurements on a cylinder 显示文摘 | Leach W M Paris D T | 1973 | IEEE Transactions on Antennas Propagation1973，21，4： | 1 |
| 20 | Study of oxygen - transporting cobalt (11) complexes :' novel synthesis of 3 - fluoro - 2 - hydroxybenzaldehyde 显示文摘 | Aymes D J Paris M R | 1980 | Bulletin de la Societe Chimique de France1980，，34： | 1 |
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