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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Diagnosis of Crohn's disease in India where tuberculosis is widely prevalent显示文摘AIM:To define the parameters that positively predict diagnosis of Crohn's disease (CD) and differentiate it from gastrointestinal tuberculosis (GITB). METHODS:This prospective study over 3 years was carried out in the consecutive Indian patients with definite diagnosis of CD and equal numbers of patients with definite diagnosis of GITB. Demographic, clinical, laboratory, morphological and histological features were noted in all the patients. Serological tests such as p-ANCA, c-ANCA, IgA ASCA and IgG ASCA, were performed. Endoscopic biopsy and/or surgical tissue specimens were subjected to smear and culture for acid-fast bacilli (AFB) and tissue polymerase chain reaction for tuberculosis (TB PCR). Diagnosis of CD and GITB was based on the standard criteria. Data were analyzed using univariate Chi-square test and multiple logistic regression (MLR). RESULTS:The study is comprised of 26 patients with CD (age 36.6 ± 8.6 year, male:female, 16:10) and 26 patients with GITB (age 37.2 ± 9.6 year, male:female, 15:11). The following clinical variables between the two groups (CD vs TB) were significant in univariate analysis:duration of symptoms (58.1 ± 9.8 vs 7.2 ± 3.4 mo), diarrhoea (69.2% vs 34.6%), bleeding per rectum (30.7% vs 3.8%), fever (23.1% vs 69.2%), ascites (7.7% vs 34.6%) and extra-intestinal manifestations of inflammatory bowel disease (61.5% vs 23.1%). Of these, all except ascites and extra-colonic manifestations were found statistically significant by MLR. Accuracy of predicting CD was 84.62% based on the fever, bleeding P/R, diarrhoea and duration of symptoms while it was 63.4% when histology was reported as inflammatory bowel disease and 42.3% when there was recurrence of disease after surgery. Accuracy of predicting GITB was 73.1% when there was co-existing pulmonary lesions and/or abdominal lymphadenopathy;75% when tuberculosis was reported in histology;63.4% when granuloma was found in histology;82.6% when TB PCR was positive;and 61.5% when smear and/ or culture was positive for AFB. Serological test was not useful in differentiation of CD from GITB. Positivity rates for CD and GITB were:p-ANCA-3.8% and 3.8%, c-ANCA-3.8% and 0%, IgA ASCA-38.4% and 23.1%, and IgG ASCA-38.4% and 42.3%, respectively. CONCLUSION:Simple clinical parameters like fever, bleeding P/R, diarrhoea and duration of symptoms have the highest accuracy in differentiating CD from GITB. | Deepak N Amarapurkar Nikhil D Patel Priyamvada S Rane | 2008 | World Journal of Gastroenterology2008，14，5： | 24 |
| 3 | Diabetes mellitus:An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity显示文摘Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge numlier of population in the world.It is mainly characterized by chronic hyperglycemia,resulting from defects in insulin secretion or insulin action.It is predicated that the number of diabetes person in the world could reach upto 366 million by the year 2030.Even though the cases of diabetes are increasing day by day,except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so far.Thus,the objective of the present review is to provide an insight over the pathophysiological and etiological aspects of diabetes mellitus along with the remedies available for this metabolic disorder.The review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used nowadays.Alloxan and streptozotocin are mainly used for evaluating the antidiabetic activity of a particular drug.This review contain list of medicinal plants which have been tested for their antidiabetic activity in the alloxan induced diabetic rat model.From the available data in the literature,it was found that plant having antidiabetic activity is mainly due to the presence of the secondary metabolite.Thus,the information provided in this review will help the researchers for the development of an alternative methods rather than insidin and oral hypoglycemic agents for the treatment of diabetes niellitus,which will minimize the complication associated with the diabetes and related disorder. | Patel DK Kumar R Laloo D Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 17 |
| 4 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 5 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 6 | Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects显示文摘 | DK Patel R Kumar D Laloo S Hemalatha | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 2 |
| 7 | Hypocholesterolemic and antiaggregatory properties of 2-hydroxytetronic acid redox analogs and their relationship to clofibric acid显示文摘 | Witiak D T Kokrady S S Patel S T | 1982 | J Med Chem1982，25，1： | 1 |
| 8 | Studies on the GH/SL gene family: cloning of African lungfish ( Protopterus annectens )growth hormone and somatolactin and Toad (Bufo mar/nus ) growth hormone 显示文摘 | May D Alrubaian J Patel S | 1999 | Gen Comp Endocrinol1999，113，： | 1 |
| 9 | Electrically tunable optical filter for infrared wavdength using liquid crystals in a FabryPemt etalon显示文摘 | Saifi M A Berreman D W | 1990 | Appl Phys Lett1990，57，17： | 1 |
| 10 | Disulfide-dependent multimeric assembly of resistin family hormones显示文摘 | Patel S D Rajala M W Rossetti L | 2004 | Science2004，304，： | 1 |
| 11 | Dexmedetomidine pro- vides cortical neuroprotection: Impact on anaesthetic-induced neuroapoptosis in the rat developing brain 显示文摘 | SANDERS R D SUN P PATEL S | 2010 | Acta Anaesthesiol Scand2010，54，6： | 1 |
| 12 | Studies on Synthesis, Stability, Release and Pharma- codynamic Profile of a Novel Diacerein-thymol Pro- drug显示文摘 | DHANESHWAR S PATEL V PATIL D | 2013 | Bioorg Med Chem Lett2013，28，： | 1 |
| 13 | Exosomes released frombreast cancer carcinomas stimulate cell movement 显示文摘 | Harris D A Patel S H Gucek M | 2015 | PLoSOne2015，10，17： | 1 |
| 14 | Fastdissolving films (FDFs) as a newer venture in fast dissolvingdosage forms 显示文摘 | Patel A R Prajapati D S Raval J A | 2010 | lnt J Drug Dev Res2010，2，2： | 1 |
| 15 | Relationship between interdialytic weight gain and blood pressure among pre-alent hemodialysis patients显示文摘 | Inrig J K Patel U D Gillespie B S | 2007 | Am J Kidney Dis2007，50，1： | 1 |
| 16 | Management of the controversial aspects of the antiphospholipid syndrome pregnancies:aguide for clinicians and researchers显示文摘 | Erkan D Patel S Nuzzo M | 2008 | Rheumatology(Oxford)2008，473，： | 1 |
| 17 | Measurement of gas holdup and mean bubble diameter in bubble column reactors by dynamic gas disengagement method显示文摘 | Daly J G Patel S A Bukur D B | | 0，，13： | 1 |
| 18 | Apigenin and cancer chemoprevention:Progress,potential and promise(review)显示文摘 | PATEL D SHUKLA S GUPTA S | 2007 | Int J Oncol2007，30，1： | 1 |
| 19 | Microstructure and tensile properties of thixomolded magnesium alloys 显示文摘 | Patel H Chen D Bhole S | 2010 | Journal of Alloys and Compounds2010，496，12： | 1 |
| 20 | Fixation of intertrochanteric fractures of the femur:a randomized prospective comprison of the Gamma nail and the the dynamic hip nail显示文摘 | Bridle S H Patel A D Bircher M | 1991 | J Bone Joint Surg (Br)1991，73，： | 1 |
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