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| 1 | Hepatic expression and cellular distribution of the glucose transporter family显示文摘Glucose and other carbohydrates are transported into cells using members of a family of integral membrane glucose transporter (GLUT) molecules. To date 14 members of this family, also called the solute carrier 2A proteins have been identified which are divided on the basis of transport characteristics and sequence similarities into several families (Classes 1 to 3). The expression of these different receptor subtypes varies between different species, tissues and cellular subtypes and each has differential sensitivities to stimuli such as insulin. The liver is a contributor to metabolic carbohydrate homeostasis and is a major site for synthesis, storage and redistribution of carbohydrates. Situations in which the balance of glucose homeostasis is upset such as diabetes or the metabolic syndrome can lead metabolic disturbances that drive chronic organ damage and failure, confirming the importance of understanding the molecular regulation of hepatic glucose homeostasis. There is a considerable literature describing the expression and function of receptors that regulate glucose uptake and release by hepatocytes, the most import cells in glucose regulation and glycogen storage. However there is less appreciation of the roles of GLUTs expressed by non parenchymal cell types within the liver, all of which require carbohydrate to function. A better understanding of the detailed cellular distribution of GLUTs in human liver tissue may shed light on mechanisms underlying disease pathogenesis. This review summarises the available literature on hepatocellular expression of GLUTs in health and disease and highlights areas where further investigation is required. | Sumera Karim David H Adams Patricia F Lalor | 2012 | World Journal of Gastroenterology2012，18，46： | 5 |
| 2 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 3 | Variations in microbial community composition through two soil depth profiles显示文摘 | NOAH F JOSHUA P S PATRICIA A H | 2003 | Soil Biol Biochem2003，35，1： | 1 |
| 4 | Casts of Aporrectodea caliginosa (Savigny) and Lumbricus rubellus (Hoffmeister) differ in microbial activity,nutrient availability and aggregate stability显示文摘 | Richard J H Patricia M F Jacqueline E P | 2003 | Pedobiologia2003，47，： | 1 |
| 5 | Variations in microbial communitycomposition through two soil depth profiles显示文摘 | NOAH F JOSHUA P S PATRICIA A H | 2003 | Soil Biology and Biochemistry2003，35，1： | 1 |
| 6 | Variations in microbialcommunity composition through two soil depth profiles显示文摘 | Noah F Joshua P S Patricia A H | 2003 | Soil Biology and Biochemistry2003，35，16： | 1 |
| 7 | Influence of genotype and environment on isoflavone contents of soybean显示文摘 | Joseph A H Walter R F Patricia A M | 2000 | Crop Sciences2000，40，： | 1 |
| 8 | Changes in human hepatic metabolism in steatosis and cirrhosis显示文摘AIM To understand the underlying metabolic changes in human liver disease we have applied nuclear magnetic resonance(NMR) metabolomics analysis to human liver tissue.METHODS We have carried out pilot study using 1H-NMR to derive metabolomic signatures from human liver from patients with steatosis, nonalcoholic steatohepatitis(NASH) or alcohol-related liver damage(ARLD) to identify species that can predict outcome and discriminate between alcohol and metabolic-induced liver injuries. RESULTS Changes in branched chain amino acid homeostasis, tricarboxylic acid cycle and purine biosynthesis intermediates along with betaine were associated with the development of cirrhosis in both ARLD and nonalcoholic fatty liver disease. Species such as propylene glycol and as yet unidentified moieties that allowed discrimination between NASH and ARLD samples were also detected using our approach.CONCLUSION Our high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance. | Zoe Schofield Michelle AC Reed Philip N Newsome David H Adams Ulrich L Günther Patricia F Lalor | 2017 | World Journal of Gastroenterology2017，23，15： | 1 |
| 9 | Variations in microbial community composition through two soil depth profiles 显示文摘 | Noah F Joshua P S Patricia A H | 2003 | Soil Biology and Biochemistry2003，，35： | 1 |
| 10 | Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease显示文摘 | Allister J Grant Patricia F Lalor Marko Salmi Sirpa Jalkanen David H Adams | 2002 | The Lancet2002，，9301： | 1 |
| 11 | Influence of superficial organic modification of MCM-41 matrices on drug delivery rate显示文摘 | PATRICIA H AINHOA R GERARD F | 2006 | SolidState Sci2006，8，10： | 1 |
| 12 | Variations in microbial community composition through two soil depth profiles显示文摘 | Noah F Joshua P S Patricia A H | 2003 | Soil Biology and Biochemistry2003，35，1： | 1 |
| 13 | Variations in microbial community composition through two soil depth profiles 显示文摘 | Noah F Joshua P S Patricia A H | 2003 | Soil Biology and Bio- chemistry2003，35，： | 1 |
| 14 | lnterpregnancy interval and low birth weight findings from a case-controlstudy显示文摘 | Elenice M E Ronald H G Patricia L F | 1988 | Am J Epidem1988，128，5： | 1 |
| 15 | Demonstration of a supercritical composite helicopter power transmission shaft显示文摘 | PATRICIA L H ROBERT F K MARK S D | 1990 | Journal of American Helicopter Society1990，35，1： | 1 |
| 16 | Interpregnancy interval and low birth weight findings from a case - control study 显示文摘 | Elenice M F Ronald H G Patricia L F | 1988 | Am J Epidem1988，128，5： | 1 |
| 17 | PCR multiplex for detection of Salmonella ETzteritidis, Typhi and Typhimurium and occurrence in poultry meat显示文摘 | Camila G F Angela P S Patricia H C S | 2010 | International Journal of Food Microbiology2010，139，12： | 1 |
| 18 | Variations in microbial community composition through two soil depth profiles 显示文摘 | Noah F Joshua P S Patricia A H | 2003 | Soil Biology and Biochemistry2003，35，1： | 1 |
| 19 | Global selec- tion of features for nonlinear dynamics characterization of emotional speech 显示文摘 | Patricia H Jesus B A Miguel A F | 2013 | Cognitive Computation2013，5，4： | 1 |
| 20 | Nonlinear dynamics characterization to emotional speech 显示文摘 | Patricia H Jesus B A Miguel A F | 2014 | Neu- rocomputing2014，，132： | 1 |
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