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| 1 | Role of ion channels in gastrointestinal cancer显示文摘In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer cell.The functions of ion channels in the gastrointestinal(GI)tract influence a variety of cellular processes,many of which overlap with these hallmarks of cancer.In this review we focus on the roles of the calcium(Ca^2+),sodium(Na^+),potassium(K^+),chloride(Cl^-)and zinc(Zn^2+)transporters in GI cancer,with a special emphasis on the roles of the KCNQ1 K+channel and CFTR Cl-channel in colorectal cancer(CRC).Ca^2+is a ubiquitous second messenger,serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle,apoptosis,and migration.Various members of the TRP superfamily,including TRPM8,TRPM7,TRPM6 and TRPM2,have been implicated in GI cancers,especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon cancer.Voltage-gated sodium channels(VGSCs)are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle cells.The VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC samples.Studies have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer progression.Zn2+transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers,in particular,ZIP4 up-regulation in pancreatic cancer(PC).More than 70 K+channel genes,clustered in four families,are found expressed in the GI tract,where they regulate a range of cellular processes,including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal tract.Several distinct types of K+channels are found dysregulated in the GI tract.Notable are hERG1 upregulation in PC,gastric cancer(GC)and CRC,leading to enhanced cancer angiogenesis and invasion,and KCNQ1 down-regulation in CRC,where KCNQ1 expression is associated with enhanced disease-free survival in stage II,III,and IV disease.Cl-channels are critical for a range of cellular and tissue processes in the GI tract,especially fluid balance in the colon.Most notable is CFTR,whose deficiency leads to mucus blockage,microbial dysbiosis and inflammation in the intestinal tract.CFTR is a tumor suppressor in several GI cancers.Cystic fibrosis patients are at a significant risk for CRC and low levels of CFTR expression are associated with poor overall disease-free survival in sporadic CRC.Two other classes of chloride channels that are dysregulated in GI cancers are the chloride intracellular channels(CLIC1,3&4)and the chloride channel accessory proteins(CLCA1,2,4).CLIC1&4 are upregulated in PC,GC,gallbladder cancer,and CRC,while the CLCA proteins have been reported to be down-regulated in CRC.In summary,it is clear,from the diverse influences of ion channels,that their aberrant expression and/or activity can contribute to malignant transformation and tumor progression.Further,because ion channels are often localized to the plasma membrane and subject to multiple layers of regulation,they represent promising clinical targets for therapeutic intervention including the repurposing of current drugs. | Kyle J Anderson Robert T Cormier Patricia M Scott | 2019 | World Journal of Gastroenterology2019，25，38： | 19 |
| 2 | Clostridium paraputrificum septicemia and liver abscess显示文摘We report the first case of a healthy 23-year-old female who underwent an interventional radiology-guided embolization of a hepatic adenoma, which resulted in a gas forming hepatic liver abscess and septicemia by Clostridium paraputrificum. A retrospective review of Clostridial liver abscesses was performed using a Pub Med literature search, and we found 57 clostridial hepatic abscess cases. The two most commonly reported clostridial species are C. perfringens and C. septicum(64.9% and 17.5% respectively). C. perfringens cases carried a mortality of 67.6% with median survival of 11 h, and 70.2% of the C. perfringens cases experienced hemolysis. All C. septicum cases were found to have underlying liver malignancy at the time of the presentation with a mortality of only 30%. The remaining cases were caused by various Clostridium species, and this cohort's clinical course was significantly milder when compared to the above C. perfringens and C. septicum cohorts. | Yong K Kwon Faiqa A Cheema Bejon T Maneckshana Caroline Rochon Patricia A Sheiner | 2018 | World Journal of Hepatology2018，10，3： | 4 |
| 3 | “En bloc ” caudate lobe and inferior vena cava resection following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal and liver metastasis of colorectal cancer显示文摘There are diverse protocols to manage patients with recurrent disease after primary cytoreductive surgery(CRS) with hyperthermic intraperitoneal chemotherapy(HIPEC) for peritoneal carcinomatosis. We describe a case of metachronous liver metastasis after CRS and HIPEC for colorectal cancer, successfully treated with a selective metastectomy and partial graft of the inferior vena cava. A 35-year-old female presented with a large tumour in the cecum and consequent colonic stenosis. After an emergency right colectomy, the patient received adjuvant chemotherapy. One year later she was diagnosed with peritoneal carcinomatosis, and it was decided to carry out a CRS/HIPEC. After 2 years of total remission, an isolated metachronous liver metastasis was detected by magnetic resonance imaging surveillance. The patient underwent a third procedure including a caudate lobe and partial inferior vena cava resection with a prosthetic graft interposition, achieving an R0 situation. The postoperative course was uneventful and the patient was discharged on postoperative day 17 after the liver resection. At 18-mo follow-up after the liver resection the patient remained free of recurrence. In selected patients, the option of re-operation due to recurrent disease should be discussed. Even liver resection of a metachronous metastasis and an extended vascular resection are acceptable after CRS/HIPEC and can be considered as a potential treatment option to remove all macroscopic lesions. | Patricia Sánchez-Velázquez Nicolas Moosmann Ingolf T?pel Pompiliu Piso | 2016 | World Journal of Gastroenterology2016，22，46： | 3 |
| 4 | Long-term research and development needs for wind energy for the time frame 2000-2020显示文摘 | SVEN ERIK T PATRICIA W | 2002 | Wind Energy2002，5，1： | 1 |
| 5 | A pilot-scale continuous-jet hydrate reactor显示文摘 | Phillip S Scott D M Patricia T S | | 0，，： | 1 |
| 6 | Biosorption of cadmium and copper contaminated water by Scenedesmus abundans 显示文摘 | Patricia T A Wendy S | 2002 | Chemosphere2002，47，3： | 1 |
| 7 | Exercise arid hyperten- sion显示文摘 | Karen T Lesniak PHD Patricia M | 2001 | Czar Opin Cadlot2001，16，： | 1 |
| 8 | TGF-βinduced repres-sion of CBFα1 by Smad3 decreases cbfαl and osteocalcinexpression and inhibits osteoblast differentiation显示文摘 | Tamara A Lisa C Patricia De t al | 2001 | EM-BO J2001，20，9： | 1 |
| 9 | CT-guided transthoracic needle aspiration biopsy of pulmonary nodules:needle size and pneumothorax rate显示文摘 | Patricia R Geraghty Stephen T | 2003 | Radiology2003，229，2： | 1 |
| 10 | Mod-eling risk allocation decision in construction contracts显示文摘 | LAM K C WANG D PATRICIA T K | 2007 | International Journal of Project Management2007，25，5： | 1 |
| 11 | Neutralizing antibodies derived from the B ceils of 1918 influenza pandemic survivors显示文摘 | Yu X C Tshidi T Patricia A M | 2008 | Nature2008，455，： | 1 |
| 12 | Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy显示文摘 | Juan Macías Manuel Márquez Francisco Téllez Dolores Merino Patricia Jiménez-Aguilar Luis F. López-Cortés Enrique Ortega Miguel A. von Wichmann Antonio Rivero María Mancebo Jesús Santos Montserrat Pérez-Pérez Ignacio Suárez-Lozano Alberto Romero-Palacios A | 2013 | Clinical Infectious Diseases2013，，10： | 1 |
| 13 | Modelling Risk Allocation Decision in Construction Contracts显示文摘 | LAM K C WANG D PATRICIA T K | 2007 | International Journal of Project Management2007，25，5： | 1 |
| 14 | Cooccurrence of Elevated U- rea Levels and Dinoflagellate Blooms in Temperate Estuarine Aquaculture Ponds显示文摘 | PATRICIA M G and DANIEL E T | 1999 | Applied and Environmental Microbiolo- gy1999，65，12： | 1 |
| 15 | Fischer-Tropsch synthesis:Deactivation of noble metal-promoted Co/Al2O3 catalysts显示文摘 | GARY J PATRICIA M P ZHANG Y DAS T LI J DAVIS B H | 2002 | Appl Catal A2002，233，12： | 1 |
| 16 | Expression and immunolocalization of aquaporin water channels in rat exocrine pancreas显示文摘 | Patricia T Hurleyl Carole J | 2001 | Am J Physiol Gastrointest Liver Physiol2001，280，4： | 1 |
| 17 | Chemical and Biological Characterization of Patricles by flow cytometry in the Krka estuary, Croatia 显示文摘 | Patricia M T Matin J M Annie F | 1990 | Limnol Oceanogr1990，35，： | 1 |
| 18 | Effect of during physiological hyperinsu linemia显示文摘 | PATRICIA I TAKALA T OIKONEN V | 2004 | Diabetes Care2004，27，： | 1 |
| 19 | Identification and functional validation of a unique set of drought induced genes preferentially expressed in response to gradual water stress in peanut显示文摘 | Govind G Harshavardhan V T Patricia J K | 2009 | Molec- ular Genetics and Genomics2009，281，： | 1 |
| 20 | Phosphodiesterase 4 inhibitors reduce human dendritic cell inflammatory cytokine production and Th1-polarizing capacity 显示文摘 | Heleen C Anne-Christine T Patricia S | 2003 | Int Immunol2003，15，7： | 1 |
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