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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Separation by fixed-bed adsorption of hexane isomers in zeolite BETA pellets显示文摘 | PATRICK S B SILVA J A C RODRIGUES A E | 2006 | Ind Eng Chem Res2006，45，12： | 1 |
| 3 | EEG biofeedback in the treatment of Attention Deficit/Hyperactivity Disorder 显示文摘 | Patrick N Friel B S | 2007 | Alternative Medicine Review2007，12，2： | 1 |
| 4 | Kinetic separation of hexane isomers by fixed-bed adsorption with a microporous metal-organic framework显示文摘 | PATRICK S B ZAPATA F SILVA J A C | 2007 | J Phys Chem B2007，111，22： | 1 |
| 5 | Beyond the intrinsic-extrinsic dichotomy: self-determination in motivation and learming显示文摘 | RIGBY C S DECI E L PATRICK B C | 1992 | Motiv Emot1992，16，3： | 1 |
| 6 | Heterologous protein production using the Pichia pastoris expression system显示文摘 | Macauley Patrick S Fazenda M L MeNeil B at al | 2005 | Yeast2005，22，： | 1 |
| 7 | Palifermin for oral mucositis after intensive therapy for hematologic cancers显示文摘 | Ricardo S Patrick S William B | 2004 | N Engl J Med2004，351，： | 1 |
| 8 | Heterologous protein production using the Pichia pastoris expression system显示文摘 | Macauley Patrick S Fazenda ML McNeil B | 2005 | Yeast2005，22，4： | 1 |
| 9 | Unique hole cleaning capabilities of ester-based drilling fluid system显示文摘 | Patrick K Terry A/S Graham B | | SPE0，，： | 1 |
| 10 | The value of using sandplay as a tool for counseling within a school setting显示文摘 | Tunnecliff S Patrick O B | 2004 | Australian Journal of Guidance and Counseling2004，14，2： | 1 |
| 11 | VolatiLe Organic Compound Concentrations in Residential Indoor and Outdoor and Its Persona Exposure in Korea显示文摘 | Busoon S Patrick B Wonho Y | 2003 | Environ- mental International2003，2，1： | 1 |
| 12 | A comparative study of dexmedetomidine with midazolam and midazolam alone for sedation during elective awake fiberoptic intubation显示文摘 | Bergese S D Patrick B S McSweeney T D | 2010 | J Clin Anesth2010，22，1： | 1 |
| 13 | Landscape management through integration of existing tools and emerging technologies显示文摘 | James B McCarter Jeremy S Wilson Patrick J Baker | 1998 | Journal of Forestry1998，96，6： | 1 |
| 14 | On the sound radiation of a roiling tyre 显示文摘 | Wolfgang K Patrick S Haike B | 2012 | Journal of Sound and Vibration2012，331，： | 1 |
| 15 | Heterologous protein production using the Pichia pastorisexpression system 显示文摘 | Patrick S M Fazenda M L McNeil B | 2005 | Yeast2005，22，4： | 1 |
| 16 | Com- parative structural analysis of human DEAf'Box RNA he- licases 显示文摘 | PATRICK S TOBIAS K SUSANNE V D B | 2010 | PLoS One2010，5，12： | 1 |
| 17 | Golden Indica and Japonica Rice Lines Amenable to Deregulation 显示文摘 | Tran Thi C H Salim A B Patrick S | 2003 | Plant Physiology2003，133，1： | 1 |
| 18 | SIMS Zircon U-Pb geocheronology and Sr-Nd isotopes of Ni-Cu beraing mafic- ultramafic intrusion in eastern Tianshan and Beishan in correlation with flood basalts in Tarim basin(NW China): Conetraints on a CA 280 Ma mantle plume显示文摘 | Qin K Z Su B X Patrick A S | 2011 | American Journal of Science2011，311，： | 1 |
| 19 | Unusual nerve-artery relationship in microvascular exploration for tic douloureux 显示文摘 | Patrick B S | 2005 | Neurosurgery2005，56，3： | 1 |
| 20 | Modification of ricin A chain, by addition of endoplasmic reticulum (KDEL) or Golgi (YQRL) retention sequences,enhances its cytotoxicity and translocation 显示文摘 | ZHAN J B PATRICK S OLIVER W P | 1998 | Cancer Immunol Immunother1998，46，： | 1 |
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