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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 4 | The carbon we do not see-the impact of low molecular weight compounds on carbon dynamics and respiration in forest soils:a review显示文摘 | PATRICK A W DAVID L J FINLAY R | 2005 | Soil Biology & Biochemistry2005，37，： | 1 |
| 5 | Influence of extractable iron, aluminum and manganese of P sorption in flooded acid sulfate soils 显示文摘 | Jugsujinda A Krairapanona A Patrick J R W H | 1995 | Biology and Fertility of Soils1995，20，： | 1 |
| 6 | Nitrogen and phosphorus distribution and utilization by Spartina alterniflora in a Louisiana gulf coastal marsh显示文摘 | BURESH R J DELAUNE R D PATRICK W H | 1980 | Estuaries and coasts1980，3，2： | 1 |
| 7 | Optical propertiesof cubic SiC:luminescence of nitrogen-exciton complexes,and interband absorption显示文摘 | Choyke W J Hamilton D R Patrick L | 1964 | Physical Review1964，133，4： | 1 |
| 8 | Sedimentation rates determined by ^137Cs dating in a rapidly accreting salt marsh显示文摘 | Delaune R D Patrick W H Bursch R J | 1978 | Nature1978，275，： | 1 |
| 9 | Nitrification and denitrification at the plant root and sediment interfaces in wetlands显示文摘 | Reddy K R Patrick W H Lindau C W | | 0，，： | 1 |
| 10 | Soil nitrogen loss as a result of alternate sub- mergence and drying显示文摘 | Patrick W H Wyatt R | 1964 | Soil Sci Soc Am J1964，28，5： | 1 |
| 11 | A surrey-based system for safety measurement and improvement 显示文摘 | BROOKS C PATRICK W R | 2003 | Journal of Safety Research2003，34，2： | 1 |
| 12 | Nitrous oxide emission from Gulf Coast wetlands 显示文摘 | Smith C J DeLaune R D Patrick W H Jr | 1983 | Geochimica et Cosmochimica Acta1983，47，10： | 1 |
| 13 | Phosphate release and sorption by soils and sediments:effect of aerobic and anaerobic conditions显示文摘 | PATRICK W H J KHALID R A | 1974 | Science New Series1974，186，4158： | 1 |
| 14 | Nitrification -deitrification at the plant root - sediment interfaces in wetland 显示文摘 | Reddy K R Patrick J K W H Lindau C W | 1989 | Limnology and Oceanography1989，34，6： | 1 |
| 15 | Collagen stimula- ting factors from lung in experimental paraquat poi- soning demonstrated in vitro and in vivo显示文摘 | THOMPSON W D PATRICK R S | 1984 | J Clin Pathol1984，37，： | 1 |
| 16 | Chernobyl Cs-137 used to determine sediment accretion rates at selected north European coastal wetlands显示文摘 | Callaway J C Delaune R D Patrick W H | 1996 | Limnology and Oceanography1996，41，3： | 1 |
| 17 | Desulfurization of Fuel Oil by Oxidation and Extraction 显示文摘 | Patrick S T James R K John W E | 1990 | Industrial & Engineering Chemist Research1990，29，3： | 1 |
| 18 | Measuring Organization Perfor- mance in Strategic Human Resource Management:Problems, Prospects, and Performance Information Markets 显示文摘 | EDWARD W R PATRICK M W | 1998 | Human Re- source Management Review1998，8，3： | 1 |
| 19 | Nitrogen transformation and loss in flooded soils and sediments显示文摘 | REDDY K R PATRICK W H | 1984 | Crit Rev Envir Control1984，13，： | 1 |
| 20 | Aerenchyma formation and methane and oxygen exchange in rice显示文摘 | Kludze H K De Laune R D Patrick W H | 1993 | Soil Science Society of Arnerica Journal1993，57，2： | 1 |
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