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| 1 | Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases显示文摘Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to cholestasis.Described in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not known.To date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected patients.We report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated cases.Presentation includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis studies.In HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral therapy.Lymphoma was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other cases.In HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes. | Ana Paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner Kevin P High Caryn G Morse | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 2 | Re-challenge chemotherapy with gemcitabine plus carboplatin in patients with non-small cell lung cancer显示文摘Despite recent improvements to current therapies and the emergence of novel agents to manage advanced non-small cell lung cancer(NSCLC),the patients′overall survival remains poor.Re-challenging with first-line chemotherapy upon relapse is common in the management of small cell lung cancer but is not well reported for advanced NSCLC.NSCLC relapse has been attributed to acquired drug resistance,but the repopulation of sensitive clones may also play a role,in which case re-challenge may be appropriate.Here,we report the results of re-challenge with gemcitabine plus carboplatin in 22 patients from a single institution who had previously received gemcitabine plus platinum in the first-line setting and had either partial response or a progression-free interval of longer than 6 months.In this retrospective study,the charts of patients who underwent second-line chemotherapy for NSCLC in our cancer center between January 2005 and April 2010 were reviewed.All the patients who received a combination of gemcitabine and carboplatin for re-challenge were included in the study.These patients were offered second-line treatment on confirmation of clear radiological disease progression.The overall response rate was 15%and disease control rate was 75%.The median survival time was 10.4 months,with 46%of patients alive at 1 year.These results suggest that re-challenge chemotherapy should be considered in selected patients with radiological partial response or a progression-free survival of longer than 6 months to the initial therapy. | Khurum Khan Gerard G Hanna Lynn Campbell Paula Scullin Adnan Hussain Ruth L Eakin Jonathan McAleese | 2013 | Chinese Journal of Cancer2013，32，10： | 3 |
| 3 | Protective effect of Bifidobacterium pseudocatenulatum CECT 7765 against induced bacterial antigen translocation in experimental cirrhosis显示文摘 | Alba Moratalla Isabel Gómez‐Hurtado Arlette Santacruz ángela Moya Gloria Peiró Pedro Zapater José M. González‐Navajas Paula Giménez José Such Yolanda Sanz Rubén Francés | 2014 | Liver Int2014，，6： | 2 |
| 4 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 5 | Analysis of fungal diversity in the wheat rhizosphere by sequencing of cloned PCR-amplified genes encoding 18S rRNA and temperature gradient gel electrophoresis显示文摘 | ERIC S PAULA L BOET G | 1999 | Appl Environ Microb1999，65，6： | 1 |
| 6 | In vitro assessment of Metarhizium anisopliae isolates to control the cattle tick Boophilus microplus 显示文摘 | Ana Paula G F habajara da S V J Aoi M | 2000 | Veterinary Parasitology2000，91，： | 1 |
| 7 | Two mechanisms of permeation of small neutral molecules and hydrated ions across phospholipid bilayers显示文摘 | Volkov A G Paula S Deamer D W | 1997 | Bioelectrochemistry and Bioenergetics1997，，42： | 1 |
| 8 | A challenge to meet the future:Nursing education in Oregon,2010显示文摘 | Paula G H Katherine S S Christine A T | | 0，，04： | 1 |
| 9 | Adaptive beamforming u- sing the multistage Wiener filter with a soft stop显示文摘 | Ricks D C Paula G C Goldstein J S | 2002 | IEEE Trans- actions on Communications2002，50，6： | 1 |
| 10 | Five-Level triage:A report from trs,ACEP/ENA five-level triage Task force 显示文摘 | Christopher M Paula T Nicki G etal | 2005 | J Emerg Nurs2005，31，： | 1 |
| 11 | Nitrogen availability influences the biochemical composition and photosynthesis of tank-cultivated Ulva rigida (Chlorophyta)显示文摘 | Juan Luis Gómez Pinchetti Elena del Campo Fernández Paula Moreno Díez Guillermo García Reina | 1998 | Journal of Applied Phycology1998，，4： | 1 |
| 12 | Reactive oxygen species and induction of lignin peroxidase in phanerochaete chrysosporium显示文摘 | Paula A Belinky NF Sergey L Shimon G Dosoretz CG | | 0，，11： | 1 |
| 13 | Fish off flavor analysis by hcadspace and off line purge-and-trap followed by HRGC MS 显示文摘 | Santos G V Da Cunha Veloso M C De Paula Pereira PA | 2001 | American Lab-oratory2001，33，24： | 1 |
| 14 | Research Productivity Over the Life Cycle:Evidence for Academic Scientists显示文摘 | Sharon G and Paula E Stephan | 1991 | American Economic Review1991，，： | 1 |
| 15 | Genetic control of the mitochondrial form of superoxide dismutase in hexaploid wheat显示文摘 | Paula R Neuman P R Hart G E | 1986 | Biochemical Genetics1986，24，56： | 1 |
| 16 | Five level triage= a report from the ACEP/ENA five - level triage task force显示文摘 | Christopher M Paula T Nichi G | 2005 | J Emer- gency Nuts2005，31，： | 1 |
| 17 | Manganese-containing superoxide dismutase from the white-rot fimgus Phanerochaete chrysosporium: its function, expression and gene structure 显示文摘 | Paula A B Doron G Bella K | 2002 | Enzyme Microb Technol2002，31，： | 1 |
| 18 | Impact of plant essential oils on microbiological, organoleptie and quality markets of minimally processed vegetables 显示文摘 | Jorge G Paula B Julien L | 2009 | Innovative Food Science and Emerging Technologies2009，10，2： | 1 |
| 19 | Feeding cessation effects of chlorantraniliprole,a new anthranilic diamide insecticide,in comparison with several insecticides in distinct chemical classes and mode-of-action groups显示文摘 | GREG T H MELISSA Z PAULA G M | 2009 | Pest Manage Sci2009，65，： | 1 |
| 20 | Dcvelopment and application of a PCR diagnostic assay for the accurate and rapid identifieation of the nematophagous fungus Duclddingtonia flagrans显示文摘 | Paula K Barbara G Richard F | | 0，，： | 1 |
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