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| 1 | Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis显示文摘BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an epiphenomenon.This study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe hypertriglyceridemia.METHODS:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum triglycerides.The APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being taken.The patients' progression,etiological diagnosis,hospital stay and clinical and radiological severity were all recorded.RESULTS:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) origin.Compared with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes mellitus.They usually consumed alcohol or consumed it excessively on the days before admission.Also,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption. | Radka Ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos Pedro González-Santos Pedro Valdivielso | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 26 |
| 2 | Microperforated insertion units: An alternative strategy to design microperforated panels显示文摘 | Jaime Pfretzschner Pedro Cobo Francisco Simón María Cuesta Alejandro Fernández | 2005 | Applied Acoustics2005，，1： | 1 |
| 3 | A model comparision of the absorption coefficient of a microperforated insertion unit in the frequnency and time domains显示文摘 | Pedro Cobo | 2008 | Applied Acoustics2008，69，： | 1 |
| 4 | Optimization of multiple-layer microperforated panels by simulated Annealing显示文摘 | Heidi Ruiz Pedro Cobo Finn Jacobsen | 2011 | Applied Acoustics2011，72，10： | 1 |
| 5 | A simple single-switch single-stage AC/DC converter with fast output voltage regulation 显示文摘 | Oscar Garci a Jose A Cobos Pedro Alou | 2003 | IEEE Transactions on Power Electronics2003，17，2： | 1 |
| 6 | A simple single-switch single-stage ac/dc converter with fast output voltage regulation显示文摘 | Oscar Garci a Jose A Cobos Pedro Alou | 2003 | IEEE Transactions on Power Electronics2003，17，2： | 1 |
| 7 | Optimization of mul- tiple-layer microperforated panels by simulated annealing显示文摘 | Heidi Ruiz Pedro Cobo Finn Jacobsen | 2011 | Ap- plied Acoustics2011，72，10： | 1 |
| 8 | Microperforated insertion units: an alternative strategy to design microperforated panels显示文摘 | JAIME Pfretzschner PEDRO Cobo FRANCISCO Simon | 2006 | Applied Acoustics2006，，67： | 1 |
| 9 | Low- fi'equency absorption using a two-layer system with active control of input impedance显示文摘 | PEDRO COBO ALEJANDRO FERNANDEZ | 2003 | JASA2003，114，6： | 1 |
| 10 | Hybrid passive- active absorption of a microperforated panel in free field conditions 显示文摘 | PEDRO COBO MARIA CUESTA | 2007 | JASA2007，121，6： | 1 |
| 11 | Pedigree analysis of 220 almond genotypes reveals two world mainstream breeding lines based on only three different cultivars显示文摘Loss of genetic variability is an increasing challenge in tree breeding programs due to the repeated use of a reduced number of founder genotypes.However,in almond,little is known about the genetic variability in current breeding stocks,although several cases of inbreeding depression have been reported.To gain insights into the genetic structure in modern breeding programs worldwide,marker-verified pedigree data of 220 almond cultivars and breeding selections were analyzed.Inbreeding coefficients,pairwise relatedness,and genetic contribution were calculated for these genotypes.The results reveal two mainstream breeding lines based on three cultivars:“Tuono”,“Cristomorto”,and“Nonpareil”.Descendants from“Tuono”or“Cristomorto”number 76(sharing 34 descendants),while“Nonpareil”has 71 descendants.The mean inbreeding coefficient of the analyzed genotypes was 0.041,with 14 genotypes presenting a high inbreeding coefficient,over 0.250.Breeding programs from France,the USA,and Spain showed inbreeding coefficients of 0.075,0.070,and 0.037,respectively.According to their genetic contribution,modern cultivars from Israel,France,the USA,Spain,and Australia trace back to a maximum of six main founding genotypes.Among the group of 65 genotypes carrying the S f allele for self-compatibility,the mean relatedness coefficient was 0.125,with“Tuono”as the main founding genotype(24.7%of total genetic contribution).The results broaden our understanding about the tendencies followed in almond breeding over the last 50 years and will have a large impact into breeding decision-making process worldwide.Increasing current genetic variability is required in almond breeding programs to assure genetic gain and continuing breeding progress. | Felipe Perez de los Cobos Pedro J.Martinez-Garcia Agusti Romero Xavier Miarnau Iban Eduardo Werner Howad Mourad Mnejja Federico Dicenta Rafel Socias i Company Maria J.Rubio-Cabetas Thomas M.Gradziel Michelle Wirthensohn Henri Duval Doron Holland Pere Arus Francisco J.Vargas Ignasi Batlle | 2021 | Horticulture Research2021，8，1： | 0 |
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