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| 1 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 2 | Clinicopathological analysis of patients with gastric cancer in 1200 cases显示文摘INTRODUCTIONGastric cancer is one of the most common fatal malignancies in the world. The prognosis is generally poor in advanced gastric cancer .The low survival is related to delayed diagnosis, metastasis and recurrence after operation .The aim of this paper was to find correlation between clinical factors was to find correlation between clinical factors and biologic behavior of gastric cancer in a series of 1200 patients undergoing surgical resection. | Wei Xin Niu Xin Yu Qin Han Liu Cheng Pei Wang Surgical Department, Zhongshan Hospital, Fu Dan University Medical Center, Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，2： | 29 |
| 3 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 4 | Effects of Honghua preserved amniotic membrane on scar healing in experimental glaucoma surgery显示文摘AIM:To investigate the efficacy and safety of Honghua preserved amniotic membrane(AM)for preventing scar formation of the filtering bleb in a rabbit model of glaucoma trabeculectomy surgery.METHODS:Totally 36 rabbits(36 eyes)were randomly divided into 3 groups:the experimental group(ocular trabeculectomy in combination with Honghua preserved AM transplantation),the control group(ocular trabeculectomy surgery in combination with AM implantation),and the blank group(single trabeculectomy).Clinical observations[including intraocular pressure(IOP),filtering blebs and complications],MassonTrichrome staining,real-time quantitative reverse transcription-polymerase chain reaction(real-time PCR),Western blot were performed on different time points(D1,D7,D14,D21 and D56)after the surgery.RESULTS:After operated for 14d,there were statistically significant differences in the filtering blebs compared to the situation before operation(P<0.05),whereas no statistically difference on that among three groups(P>0.05).After 21d,the IOP of experimental group was lowest(P<0.05).There was significant difference between control group and blank group(P<0.05).On postoperative D14,the mean number of fibroblasts in the experimental group was significantlylower(40.6±10.2)compared to those in the control group(54.4±10.8)and blank group(68.2±11.6)(P<0.05,respectively).The mean numbers of the macrophage in the experimental and control groups were respcitively significantly lower versus the blank group(P<0.05,P<0.05,respectively).Compared to that in blank group,the level of transforming growth factor-β(TGF-β1)expression in sclera and conjunctival areas was reduced in the experimental and control groups on protein and mRNA level(P<0.05),but not significant difference between these two groups(P>0.05).CONCLUSION:The trabeculectory surgery with Honghua preserved AM can control IOP,sustain the functional filtration bleb,inhibit the proliferation of fibroblasts and open the filtrating pathway on the rabbit glaucoma models. | Yi Shao Yao Yu Qiu-Ping Liu Jing-Ming Li Fei Dong Xin Huang Chong-Gang Pei Ping Tu Hen-Hui Li Gui-Ping Gao | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 16 |
| 5 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 6 | Characteristics of the lunar samples returned by the Chang'E-5 mission显示文摘Forty-five years after the Apollo and Luna missions returned lunar samples,China's Chang’E-5(CE-5)mission collected new samples from the mid-latitude region in the northeastern Oceanus Procellarum of the Moon.Our study shows that 95%of CE-5 lunar soil sizes are found to be within the range of 1.40-9.35μm,while 95%of the soils by mass are within the size range of 4.84-432.27μm.The bulk density,true density and specific surface area of CE-5 soils are 1.2387 g/cm^(3),3.1952 g/cm^(3) and 0.56 m^(2)/g,respectively.Fragments from the CE-5 regolith are classified into igneous clasts(mostly basalt),agglutinate and glass.A few breccias were also found.The minerals and compositions of CE-5 soils are consistent with mare basalts and can be classified as low-Ti/low-Al/low-K type with lower rare-earth-element contents than materials rich in potassium,rare earth element and phosphorus.CE-5 soils have high FeO and low Mg index,which could represent a new class of basalt. | Chunlai Li Hao Hu Meng-Fei Yang Zhao-Yu Pei Qin Zhou Xin Ren Bin Liu Dawei Liu Xingguo Zeng Guangliang Zhang Hongbo Zhang Jianjun Liu Qiong Wang Xiangjin Deng Caijin Xiao Yonggang Yao Dingshuai Xue Wei Zuo Yan Su Weibin Wen Ziyuan Ouyang | 2022 | National Science Review2022，9，2： | 12 |
| 7 | Association of CYP3A polymorphisms with the pharmacokinetics of cyclosporine A in early post- renal transplant recipients in China显示文摘目的: 回顾地评估细胞色素 P450 3A (CYP3A ) 和 ATP 有约束力的盒子亚科 B 的协会成员 1 (ABCB1 ) 有用汉语的 cyclosporine A (CsA ) 的 pharmacokinetics 的基因多型性肾移植病人。 | Xiang-guang MENG Cheng-xian GUO Guo-qing FENG Ying-chun ZHAO Bo-ting ZHOU Jian-le HAN Xin CHEN Yong SHI Hong-yao SHI Ji-ye YIN Xiang-dong PENG Qi PEI Wei ZHANG Guo WANG Meng HE Min LIU Jing-ke YANG Hong-hao ZHOU | 2012 | Acta Pharmacologica Sinica2012，33，12： | 11 |
| 8 | Modifi cation of wheat bran insoluble and soluble dietary fibers with snail enzyme显示文摘Insoluble dietary fiber(IDF)and soluble dietary fiber(SDF)extracted from wheat bran were modifi ed by snail enzyme and their physicochemical properties(water retention capacity and oil retention capacity),functional properties(cholesterol adsorption capacity,glucose adsorption capacity and antioxidant activity)and structural characterizations were evaluated.The results showed that snail enzyme modification led to the significant increase in oil retention capacity of IDF,glucose adsorption capacity and cholesterol adsorption capacity of IDF and SDF.Enzymatic modification also markedly improved the DPPH radical scavenging capacity and reducing power of IDF and SDF.Meanwhile,scanning electron microscopy(SEM)analysis indicated the microstructures of IDF and SDF powders were signifi cantly changed.Fourier transfer-infrared spectrometry(FT-IR)showed that snail enzyme modifi cation could degrade the part of cellulose and hemicellulose of IDF and SDF.All these improved physicochemical and functional properties of IDF and SDF might depend on their structural changes.It suggested that snail enzyme modifi cation could effectively improve physicochemical and functional properties of IDF and SDF from wheat bran. | Xin Liu Keke Suo Pei Wang Xue Li Limin Hao Jiaqing Zhu Juanjuan Yi Qiaozhen Kang Jinyong Huang Jike Lu | 2021 | Food Science and Human Wellness2021，10，3： | 10 |
| 9 | Variable Selection for Semiparametric Varying-Coefficient Partially Linear Models with Missing Response at Random显示文摘在这份报纸,我们在场由把基础功能近似与为 semiparametric 变化系数估计方程惩罚相结合的一个可变选择过程有失踪的反应在的部分线性的模型随机。建议过程同时在参量的部件和 nonparametric 部件选择重要变量。与调节参数的适当选择,我们建立可变选择过程的一致性和调整评估者的集中率。模拟研究被承担估计建议可变选择过程的有限样品表演。 | Pei Xin ZHAO Liu Gen XUE | 2011 | Acta Mathematica Sinica,English Series2011，27，11： | 9 |
| 10 | Alleviation by abscisic acid of Al toxicity in rice bean is not associated with citrate efflux but depends on ABI5-mediated signal transduction pathways显示文摘Under conditions of aluminum(Al) toxicity,which severely inhibits root growth in acidic soils, plants rapidly alter their gene expression to optimize physiological fitness for survival. Abscisic acid(ABA) has been suggested as a mediator between Al stress and gene expression, but the underlying mechanisms remain largely unknown. Here,we investigated ABA-mediated Al-stress responses, using integrated physiological and molecular biology approaches.We demonstrate that Al stress caused ABA accumulation in the root apex of rice bean(Vigna umbellata [Thunb.] Ohwi &Ohashi), which positively regulated Al tolerance. However,this was not associated with known Al-tolerance mechanisms. Transcriptomic analysis revealed that nearly one-third of the responsive genes were shared between the Al-stress and ABA treatments. We further identified a transcription factor, ABI5, as being positively involved in Al tolerance. Arabidopsis abi5 mutants displayed increased sensitivity to Al, which was not related to the regulation of AtALMT1 and AtMATE expression. Functional categorization of ABI5-mediated genes revealed the importance of cell wall modification and osmoregulation in Al tolerance, a finding supported by osmotic stress treatment on Al tolerance. Our results suggest that ABA signal transduction pathways provide an additional layer of regulatory control over Al tolerance in plants. | Wei Fan Jia Meng Xu Pei Wu Zhi Xin Yang He Qiang Lou Wei Wei Chen Jian Fen Jin Shao Jian Zheng Jian Li Yang | 2019 | Journal of Integrative Plant Biology2019，61，2： | 9 |
| 11 | Crustal velocity structure of the Shaowu-Nanping-Pingtan transect through Fujian from deep seismic sounding-tectonic implications显示文摘The Shaowu-Nanping-Pingtan deep seismic sounding profile is located in northern Fujian Province. High-quality seismic sounding data were acquired by five large explosive blasts received by 133 digital seismic instruments along the profile. Based on seismic facies analysis and travel-time picking on shot record sections, a model of the velocity structure of upper crust was developed by finite-difference tomography of the first breaks; the 2-D P-wave velocity structure and tectonic characteristics of the crust were interpreted further by fitting of waveforms and seismic travel times. The results show that the top of the crystalline basement is buried at depths of 2.0–4.0 km, with the deepest buried up to 4.0 km within the Fuzhou Basin. The Moho interface was found to be deeper in the west and shallower in the east(i.e., 30.0 km near the coast, increasing to 33.0 km northwestward). The lower crust on the east side of the Zhenghe-Haifeng Fault Zone has a smoothly varying gradient structure, whereas on the west side it has two distinct layers with a boundary between those layers at a depth of 23 km. Seismic velocities on the west side are generally lower than on the east side; a low velocity layer is observed with a lowest speed of 6.25 km/s at a depth of 22 km on the west side, which may consist of partially molten material. The Zhenghe-Haifeng Fault is a deep crustal fault, and should be a channel for deep material upwelling; it has a direct relationship with multiple stages of continental tectonic movements in Southern China and with multiple magmatic events that started in the Proterozoic and ended in the of late Tertiary in Fujian. | LI Pei JIN Xin WANG ShanXiong CAI HuiTeng | 2015 | Science China Earth Sciences2015，58，12： | 9 |
| 12 | MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling显示文摘发信号的 BMP 怎么集成到并且使动摇人的 pluripotent 干细胞(hPSCs ) 的 pluripotency 电路开始区别进单个细菌层是一个长期的难题。这里,我们报导肌肉片断 homeobox 2 (MSX2 ) , msh 家庭的一个 homeobox 抄写因素, BMP 发信号的直接目标基因和 hPSC 到 mesendoderm 的区别的一个主人调停人。MSX2 的强制表示足够废除 pluripotency 并且导致 hPSCs 的指导 mesendoderm 区别,当 MSX2 弄空损害 mesendoderm 正式就职时。MSX2 是在 hPSCs 的 BMP 小径的直接目标基因,并且能被 Wnt 信号 synergistically 在 mesendoderm 正式就职期间经由 LEF1 激活。而且, MSX2 使动摇通过到 SOX2 倡导者和 SOX2 抄写的压抑的直接绑定的 pluripotency 电路,当 MSX2 通过节的倡导者的直接绑定和激活由 SOX2 的同时的抑制和节的表示的正式就职控制 mesendoderm 系承诺时。有趣地, SOX2 能支持 MSX2 蛋白质的降级,建议在在干细胞命运的控制的二个指定系的因素之间的相互的对抗。一起,我们的调查结果揭示使动摇的关键新机制在 hPSCs 的 pluripotency 和指导系承诺。 | Qingqing Wu Leisheng Zhang Pei Su Xiaohua Lei Xin Liu Hongtao Wang Lisha Lu Yang Bai Tao Xiong Dong Li Zhengmao Zhu Enkui Duan Erlie Jiang Sizhou Feng Mingzhe Hang Yuanfu Xu Fei Wang Jiaxi Zhou | 2015 | Cell Research2015，25，12： | 8 |
| 13 | Can ultrasound predict the severity of acute pancreatitis early by observing acute fluid collection?显示文摘INTRODUCTIONThe spectrum of acute pancreatitis (AP) ranges from a mild spontaneously resolved disorder to severe disease with mortality up to 20%-48.4%[1-3]. sAP is defined as the AP with organ failure and /or local complications which developed form acute fluid collection (AFC) including necrosis ,abscess , pseudocyst formation into or around the pancreas [4]. | Yan Luo1 Chao Xin Yuan1 Yu Lan Peng1 Pei Lin Wei1 Zhao Da Zhang2 Jun Ming Jiang3 Lin Dai1 Yun Kai Hu1 1Ultrasound Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China2Surgery Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China3Tranditional Chinese Medicine, Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China | 2001 | World Journal of Gastroenterology2001，7，2： | 8 |
| 14 | Adaptive Algorithms of Nonlinear Approximation with Finite Terms显示文摘This paper deals with realizable adaptive algorithms of the nonlinear approximation withfinite terms based on wavelets.We present a concrete algorithm by which we may find the requiredindex set A_m for the greedy algorithm G_m^p(·,Ψ).This makes the greedy algorithm realize the nearbest approximation in practice.Moreover,we study the efficiency of the finite-term approximation ofanother algorithm introduced by Birge and Massart. | Wen Bin WEI Yue Sheng XU Pei Xin YE | 2007 | Acta Mathematica Sinica,English Series2007，23，9： | 7 |
| 15 | Prediction of Coke Yield of FCC Unit Using Different Artificial Neural Network Models显示文摘In fluid catalytic cracking(FCC) unit, it is greatly important to control the coke yield, since the increase of coke yield not only leads to the reduction of total liquid yield, but also affects the heat balance and operation of FCC unit. Consequently, it is significant to predict the coke yield accurately. The coke formation and burning reactions are affected by many parameters which influence each other, so it is difficult to establish a prediction model using traditional models. This paper combines the industrial production data and establishes a generalized regression neural network(GRNN) model and a back propagation(BP) neural network model to predict the coke yield respectively. The comparison and analysis results show that the accuracy and stability of the BP neural network prediction results are better than that of the GRNN. Then, the particle swarm optimization to optimize BP neural network(PSO-BP) and genetic algorithm to optimize the BP neural network(GA-BP) were further used to improve the prediction precision. The comparison of these models shows that they can improve the prediction precision. However, considering the accuracy and stability of the prediction results, the GA-BP model is better than PSO-BP model. | Su Xin Wu Yingya Pei Huajian Gao Jinsen Lan Xingying | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，3： | 7 |
| 16 | Present Situation of Eutrophication of Landscape Water Body and Its Prevention and Control Measures显示文摘At present,all kinds of pollutants are discharged into the landscape water body,and the landscape water body is mostly static or slow flow state. This leads to the deepening of water pollution,eutrophication,blackening of water body,and stench and flood disasters occur frequently. This makes the urban landscape water lose its ornamental value,affects the effective operation of ecological function,and will also endanger the health of residents. Reclaimed water is one of the common methods of modern landscape water,but reclaimed water contains a lot of nitrogen and phosphorus,which will make the eutrophication of water body increase,and easily lead to ' algal blooms',water quality deterioration,and loss of landscape function. Therefore,understanding the current situation of landscape water eutrophication and effective prevention and control measures has become one of the water environment problems to be solved. | Qingyu LU Wei XIN Jiangli NIE Yan ZHANG Yi PEI | 2019 | Asian Agricultural Research2019，11，3： | 7 |
| 17 | Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells显示文摘Yamanaka 因素(Oct3/4, Sox2, Klf4, c-Myc ) 高度在胚胎的茎(ES ) 被表示房间,和他们的在表示上能在老鼠和人的体的房间导致 pluripotency,显示这些因素调整为 ES 房间 pluripotency 必要的发展发信号网络。然而,发信号的小径的全身的分析由 Yamanaka 因素调整了充分还没被描述了。在这研究,我们鉴别一个整个染色体上的内长的 Yamanaka 因素的目标倡导者在 E14.1 鼠标 ES 房间用薄片(染色质 immunoprecipitation ) 放大 -on-chip,并且我们发现这四个因素共同占据 58 个倡导者。有趣地,当 Oct4 和 Sox2 作为核心因素被分析时, Klf4 工作了为发展规定提高核心因素,而 c-Myc 似乎在调整新陈代谢起一个不同作用。小径分析表明 Yamanaka 因素一起调整由 16 条发展发信号小径,其九条在 ES 房间代表更早未知的小径组成的一个发展发信号网络,包括 apoptosis 和房间周期小径。我们进一步从在老鼠 ES 房间检验 Yamanaka 因素的最近的研究分析了数据。有趣地,这分析也揭示了 16 条发展发信号小径, 14 条小径重叠,由这研究揭示了,尽管有目标基因和发信号的小径由每个单个 Yamanaka 因素调整了在这二数据集之间显著地不同。我们建议 Yamanaka 因素极其调整由约十二条关键发展发信号小径组成也维持 ES 房间并且可能的 pluripotency 导致 pluripotent 干细胞的一个发展发信号网络。 | Xiaosong Liu Jinyan Huang Taotao Chen Ying Wang Shunmei Xin Jian Li Gang Pei Jiuhong Kang | 2008 | Cell Research2008，18，12： | 6 |
| 18 | Baicalin and deferoxamine alleviate iron accumulation in different brain regions of Parkinson's disease rats显示文摘Previous studies found that iron accumulates in the substantia nigra of Parkinson's disease patients. However, it is still unclear whether other brain regions have iron accumulation as well. In this experiment, rats with rotenone-induced Parkinson's disease were treated by gastric perfusion of baicalin or intraperitoneal injection of deferoxamine. Immunohistochemical staining demonstrated that iron accumulated not only in the substantia nigra pars compacta, but also significantly in the striatum globus pallidus, the dentate gyrus granular layer of the hippocampus, the dentate-interpositus and the facial nucleus of the cerebellum. Both baicalin and deferoxamine, which are iron chelating agents, significantly inhibited iron deposition in these brain areas, and substantially reduced the loss of tyrosine hydroxylase-positive cells. These chelators also reduced iron content in the substantia nigra. In addition to the substantia nigra, iron deposition was observed in other brain regions as well. Both baicalin and deferoxamine significantly inhibited iron accumulation in different brain regions, and had a protective effect on dopaminergic neurons. | Pei Xiong Xin Chen Chunyan Guo Nan Zhang Baocang Ma | 2012 | Neural Regeneration Research2012，7，27： | 6 |
| 19 | Preparation and Evaluation of Novel Solid Chlorine Dioxide-based Disinfectant Powder in Single-pack显示文摘Objective To prepare and evaluate novel chlorine dioxide-based disinfectant powder in single-pack that is more convenient for use and transportation. Methods Orthogonal experiment was performed to determine the recipe of the disinfectant powder. Stability test, suspension quantitative bactericidal test, simulation field trial, and animal toxicity test were carried out to observe its bactericidal and toxicological effects. Results The orthogonal experiment showed that the type of water solution had no effect on the disinfectant powder and the best ratio of sodium chlorite to solid acid was 1:3. Ten grams of the disinfectant powder was fully dissolved in 20 mL water for 2 min, and diluted to 500 mL in water. After 5-10 min, the concentration of chlorine dioxide (ClO2) solution was 266 mg/L to 276 mg/L. After stored at 54℃ for 14 d, the average concentration of ClO2 was decreased by 5.03%. Suspension quantitative bactericidal test showed that the average killing logarithm (KL) value for both Staphylococcus aureus and Escherichia coli in 100 mg/L ClO2 solution for 2 min was over 5.00. In simulation field trial, the average descending KL value for Escherichia coli in the solution containing 100 mg/L ClO2 for 5 min was over 3.00. The mouse acute LD50 in the solution 5 times exceeded 5000 mg/kg. The disinfectant powder was not toxic and irritative to rabbit skin and had no mutagenic effect on mouse marrow polychromatic erythrocytes (PCE). Conclusion The stability and bactericidal efficacy of solid chlorine dioxide-based disinfectant powder in single-pack are good. The solution containing 100 mg/L ClO2 can kill vegetative forms of bacteria. The concentration of ClO2 on the disinfecting surface of objects is 100 mg/L. The disinfectant powder is not toxic and irritative. | MIN ZHU LI-SHI ZHANG XIAO-FANG PEI XIN XU | 2008 | Biomedical and Environmental Sciences2008，21，2： | 6 |
| 20 | Effects of Shugan Jianpi Formula(疏肝健脾方)on Myeloid-Derived Suppression Cells-Mediated Depression Breast Cancer Mice显示文摘Objective:To observe the intervention effect of Shugan Jianpi Formula(疏肝健脾方,SGJPF) on a breast cancer mouse model with depression and investigate the underlying mechanism of SGJPF in preventing the development of breast cancer.Methods:The breast cancer model was induced by inoculation of breast cancer cells,the depression model was induced by chronic stress stimuli,and the depression cancer model was established by combining the two factors.The mice were divided into 7 groups:normal control,depression model,tumor model,depression tumor model,SGJPF,chemotherapy,and SGJPF+chemotherapy groups.The last 3 groups were depression breast cancer mice and treated respectively with SGJPF,chemotherapy drug gemcitabine(GEM),and SGJPF alongside GEM.The condition of the mice was evaluated by the expression of 5-hydroxytryptamine in hippocampus after the sucrose water test and open field test,weight change,and survival time.Tumor growth was monitored with in vivo imaging.Flow cytometry was used to analyze the level of myeloid-derived suppression cell(MDSC) in the mouse spleen,T cell subsets,and the early apoptosis of CD8+T cells.Results:The SGJPF+GEM group had the highest inhibition rate and the longest survival time(P<0.01).The MDSC level and the apoptosis rate of CD8+ T cells was the highest in the SGJPF+GEM group(P<0.05).Conclusions:Depressive disorders and tumor growth could suppress the immune function of mice to different degrees,and the microenvironment in late 4T1 inflammatory breast cancer may play an important role in the pathological process.SGJYF could regulate the immune microenvironment by reducing CD8+ T lymphocyte apoptosis and tumor cell activity,increasing immune surveillance capability,and inhibiting MDSC proliferation,thus prolonging the survival time of tumor-bearing mice. | LU Yu-tong LI Jie QI Xin PEI Ying-xia SHI Wen-guang LIN Hong-sheng | 2017 | Chinese Journal of Integrative Medicine2017，23，6： | 6 |
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