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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | A simple method for obtaining reusable reactors containing immobilized trehalase:Characterization of a crude trehalase preparation immobilized on chitin particles显示文摘 | MARTINS A S PEIXOTO D N PAIVA L M C | 2006 | Enzyme and Microbial Technology2006，38，： | 1 |
| 3 | Assay of human interferon in Vero cells by several methods 显示文摘 | FERREIRA P C PEIXOTO M L SILVA M A | 1979 | J Clin Microbiol1979，9，4： | 1 |
| 4 | Microstructure and electrochemical corrosion behavior of a Pb-lwt%Sn alloy for lead-acid battery components显示文摘 | PEIXOTO L C OSORIO W R GARCIA A | 2009 | Journal of Power Sources2009，192，： | 1 |
| 5 | Towards implementation of a benthic microbial fuel cell in lake Furnas (Azores): Phylogenetic affiliation and electrochemical activity of sediment bacteria 显示文摘 | MARTINS G PEIXOTO L RIBEIRO C D | 2010 | Bioelectrochemistry2010，78，1： | 1 |
| 6 | Towards implementation of a benthic microbial fuel cell in lake Furnas (Azores):Phylogenetic affiliation and electrochemical activity of sediment bacteria显示文摘 | MARTINS G PEIXOTO L RIBEIRO D C | 2010 | Bioelectrochemistry2010，78，1： | 1 |
| 7 | An empirical model to predict soil bulk density profiles in field conditions using penetration resistance, moisture content and soil depth 显示文摘 | Hernanz J L Peixoto H Cerisola C | 2000 | Journal of Terramechanics2000，37，： | 1 |
| 8 | Soil Aggregation and Bacterial Community Structure as Affected by Till age and Cover Cropping in the Brazilian Cerrados 显示文摘 | Peixoto R S Coutinho H L C Madari B | 2006 | Soil and Tillage Research2006，90，： | 1 |
| 9 | Soil aggregation and bacterial community structure as affected by tillage and cover cropping in the Brazilian Cerrados显示文摘 | Peixoto R S Coutinho H L C Madari B | 2006 | Soil and Tillage Research2006，90，1： | 1 |
| 10 | An empirical model to predict soil bulk density profiles in field conditions using penetration resistance, moisture content and soil depth 显示文摘 | Hemanz J L Peixoto H Cerisola C | 2000 | Journal of Terramechanics2000，37，： | 1 |
| 11 | Comparison of phylogeny,venom composition and neutralization by antivenom in diversespecies of Bothrops complex显示文摘 | Sousa L F Nicolau C A Peixoto P S | 2013 | PLOS Neglected Tropical Diseases2013，7，9： | 1 |
| 12 | Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis显示文摘 | RIOU C PEREZ PEIXOTO B ROBERTS L | 2012 | PLoS One2012，7，36： | 1 |
| 13 | Mechanical properties of Sn-Zn lead-free solder alloys based on the microstructure array 显示文摘 | GARCIA L R OSORIO W R PEIXOTO L C GARCIA A | 2010 | Materials Characterization2010，61，2： | 1 |
| 14 | An empirical model to predict soil bulk density profiles in field conditions using penetration resistance, moisture content and soil depth显示文摘 | J L Hemanz H Peixoto C Cerisola | 2000 | Journal ofTerra mechanics2000，37，4： | 1 |
| 15 | Micro- structure and electrochemical corrosion behavior of a Pb-lwtSn alloy for lead-acid battery components 显示文摘 | PEIXOTO L C OSORIO W R GARCIA A | 2009 | Journal of Power Sources2009，192，2： | 1 |
| 16 | Microstructure and electrochemical corrosion behavior of a Pb-1% Sn alloy for lea&acid battery components显示文摘 | Peixoto L C Os6rio W R Garcia A | 2009 | Journal of Power Sources2009，192，： | 1 |
| 17 | The effects of Ag content and dendrite spacing on the electrochemical behavior of Pb-Ag alloys for Pb-acid battery components显示文摘 | Os6rio W R Peixoto L C Garcia A | 2013 | Journal of Power Sources2013，238，： | 1 |
| 18 | Determination of nutritional and toxic elements in pasteurized bovine milk from Vale do Paraiba region ( Brazil )显示文摘 | SOARES V A KUS M M M PEIXOTO A L C CARROCCI J S SALAZAR R F S IZARIO FILHO H J | 2010 | Food Control2010，21，1： | 1 |
| 19 | Microstructure and mechanical properties of Sn-Bi, Sn-Ag and Sn-Zn lead-free so|der alloys显示文摘 | Os 6 rio W R Peixoto L C Garcia L R | 2013 | Journal of Alloys Compounds2013，572，： | 1 |
| 20 | Reactions in multiindexed continuous mixtures: catalytic cracking of petroleum fractions 显示文摘 | Peixoto F C Medeiros J L de | 2001 | AIChE J2001，47，4： | 1 |
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