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| 1 | The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma(英文)显示文摘Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c. 2756A> G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homoeysteine and folate metabolism in lymphoma tumorigenesis. | Linnebank M Schmidt S Kolsch H Linnebank A Heun R Schmidt-Wolf IG Glasmacher A Fliessbach K Klockgether T Schlegel U Pels H | 2004 | 中国神经肿瘤杂志2004，2，2： | 3 |
| 2 | Is leptin related to systemic inflammatory response in acute pancreatitis?显示文摘瞄准:在尖锐胰腺炎评估在 leptin 和全身的发炎之间的关系。方法:有尖锐胰腺炎的连续病人被包括。身体集体索引和浆液样品在承认被获得。Leptin, TNF-alpha, IL-6, -8 和 -10 层次被 ELISA 决定。严厉根据亚特兰大标准被定义。结果:52 (29 女性) 病人们被学习。全面身体团索引在温和、严重的盒子之间是类似的,尽管有严重胰腺炎的女人有更低的身体团索引(P = 0.04 ) 并且男人证明更高的身体质量索引(P = 0.05 ) 。没有差别关于胰腺炎的严厉在 leptin 层次被发现,但是高水平趋于与增加的身体团索引和严重胰腺炎出现在男病人(P = 0.1 ) 。多,变量分析显示出的 A 在 leptin 层次和严厉之间的没有协会。与严厉联系的最强壮的 cytokine 是 IL-6。有另一 cytokines 的 leptin 的关联仅仅为 IL-8 显示出一个趋势(P = 0.058 ) 。结论:高身体团索引仅仅在男性与严厉被联系,它可能与机器人脂肪分发有关。浆液 leptin 似乎不在男性与严重结果在尖锐胰腺炎和它的协会在全身的煽动性的反应上起一个作用可能代表增加的脂肪过多的一个标记。 | Andrés Duarte-Rojo Ana Lezama-Barreda María Teresa Ramírez-Iglesias Mario Peláez-Luna Guillermo Robles-Díaz | 2006 | World Journal of Gastroenterology2006，12，27： | 2 |
| 3 | Combustion of coal as a source of N2O emission显示文摘 | WOJTOWICZ M A PELS J R MOULIJN J A | 1993 | Fuel Process Technol1993，34，1： | 1 |
| 4 | Development of a solid phase kinetic as-say for determination of enzyme activities during composting显示文摘 | Peláez C Mejía A Planas A | 2004 | ProcessBiochemistry2004，39，： | 1 |
| 5 | Feature-based regis- tration of retinal images 显示文摘 | Pel E Augliere R A Timberlake G T | 1987 | IEEE Transactions on Medical Imaging1987，6，3： | 1 |
| 6 | Primary central nervous system lymphoma: results of a pilot and phase Ⅱ study of systemic and intraventricular chemothe- rapy with deferred radiotherapy 显示文摘 | Pels H Schmidt-Wolf IG Glasmacher A | 2003 | J Clin Oncol2003，21，： | 1 |
| 7 | Non-isothermal drying of fired-clay brick,an NMRstudy 显示文摘 | van der Heijden G H A Huinink H P Pel L | 2009 | Chemical Engineering Science2009，64，12： | 1 |
| 8 | One- dimensional scanning of moisture in heated porous building materials with NMR 显示文摘 | van der HEIJDEN G H A HUININK H P PEL L | 2011 | Journal of Magnetic Resonance2011，208，2： | 1 |
| 9 | Evolution of nitrogen functionalities in carbonaceous materials during pyrolysis 显示文摘 | PELS J R KAPTEIJN F MOULIJN J A | 1995 | Carbon1995，33，11： | 1 |
| 10 | Moisture transport in heated concrete, as studied by NMR, and ist consequences for fire spalling 显示文摘 | Heijden H H A Bijnen R M W van Pel L | 2007 | Cem Con Res2007，27，6： | 1 |
| 11 | NO and N2O decomposition over coal char at fluidized-bed combustion conditions显示文摘 | Ooms A C Pels J R | 1994 | Combustion and flame1994，99，： | 1 |
| 12 | NO and N2O decomposition over coal char at fluidized-bed combustion conditions 显示文摘 | Rodriguez-Mirasol J Ooms A C Pels J R | 1994 | Combustion and Flame1994，9，34： | 1 |
| 13 | The fate of nitrogen functionalities in coal during pyrolysis and combustion 显示文摘 | WOJTOWICZ M A PELS J R MOULIJN J A | 1995 | Fuel1995，74，4： | 1 |
| 14 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 15 | N2O Emission Control in Coal Combustion显示文摘 | Wojtowicz M A Pels J R Moulijn J A | 1994 | Fuel1994，73，9： | 1 |
| 16 | Salt crystallization as damage mechanism in porous building materials--A nuclear magnetic resonance study显示文摘 | RIJNIERS L A PEL L HUININK H P | 2005 | Magnetic Resonance Imaging2005，23，2： | 1 |
| 17 | Evolution of nitrogen functionalities in carbonaceous materials during pyrolysis显示文摘 | Pels J R Kapteijn F Moulijn J A | 1995 | Carbon1995，33，： | 1 |
| 18 | Physical principles and efficience of salt extraction by poulticing显示文摘 | PEL L SAWDY A VORONINA V | 2010 | Journal of Cultural Heritage2010，11，1： | 1 |
| 19 | Prognostic significance of ictal and interictal epileptiform activity in temporal lobe epilepsy 显示文摘 | Hufnagel A Elger C E Pels H | 1994 | Epilepsia1994，35，6： | 1 |
| 20 | Evolution of nitrogen functionalities in carbonaceous, materials during pyrolysis显示文摘 | Pels J R Kapeteijn F Moulijn J A | 1995 | Carbon1995，33，16： | 1 |
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