|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 3 | Theoretical studies on molecular structure and vibrational spectra of copper phthalocyanine 显示文摘 | LID C PENG Z H | 2005 | Vibrational Spectroscopy2005，39，2： | 1 |
| 4 | White spot syndrome baculovirus(WSBV) detected in cultured and captured shrimp, crabs and other arthropods 显示文摘 | Lo C F Ho C H Peng S E | 1996 | Dis Aquat Org1996，27，： | 1 |
| 5 | Treatment of brewery wastewater using anaerobic sequencing batch reactor 显示文摘 | SHAO X W PENG D C TENG Z H | 2008 | Bioresource Technology2008，99，： | 1 |
| 6 | New 3-((2′:2',5':2''-terthiophene)-3 '-yl) acrylic acid as active layer for organic fieldeffect transistor显示文摘 | SALIM N T AW K C PENG H | 2008 | Mater Chem Phys2008，111，1： | 1 |
| 7 | A new short chain RGD-containing disintegrin,accutin,inhibits the common pathway of human platelet aggregation显示文摘 | Yeh C H Peng H C Yih J B | 1998 | Biochim Biophys Acta1998，1425，3： | 1 |
| 8 | Molecular analysis of cellulose biosynthesis in Arabidopsis显示文摘 | ARIOLI T PENG L BETZNER A S BURN J WITTKE W HERTH W CAMILLERI C H(O)FTE H PLAZINSKI J BIRCH R CORKA GLOVER J REDMOND J WILLIAMSDN R E | 1998 | Science1998，279，： | 1 |
| 9 | 显示文摘 | Wang Peng Klein C Baker R H | 2005 | J Am Chem Soc2005，，127： | 1 |
| 10 | Control system development for an advanced-technology medium-duty hybrid electric truck显示文摘 | LIN C C PENG H GRIZZLE J W | 2003 | SAE2003，，10： | 1 |
| 11 | Which encodes a RNG- type ubiquitin ligase, disrupts the adaptability of Arabidopsis to nitrogen limitation显示文摘 | Peng M S Hannam C GU H | 2007 | Plant2007，50，： | 1 |
| 12 | Field emission properties of diamond- like carbon films annealed at different temperatures 显示文摘 | LI J J GU C Z PENG H Y | 2005 | Applied Surface Science2005，251，14： | 1 |
| 13 | Effects of chronic mild stress on the development of atherosclerosis and expression of toll-like receptor 4 signaling pathway in adolescent apolipoprotein E knockout mice 显示文摘 | Gu H Tang C Peng K | 2009 | J Biomed Biotechnol2009，2009，61： | 1 |
| 14 | Novel an-ticorrosion coatings prepared from polyaniline /graphenecomposites显示文摘 | Chang C H Huang T C Peng C W | 2012 | Carbon2012，50，14： | 1 |
| 15 | Self-assembled star-shaped chlorin-core poly (6-caprolaetone) -poly ( ethyleneglycol ) diblock copolymer micelles for dual ehemo-photodynamic therapies 显示文摘 | Peng C L Shieh M J Tsai M H | 2008 | Biomaterials2008，29，26： | 1 |
| 16 | Temperature- and duration- dependent rice straw-derived biochar: Characteristics and its effects on soil properties of an UltisoI in southern China显示文摘 | PENG X YE L L WANG C H | 2011 | Soil & Tillage Research2011，112，： | 1 |
| 17 | Genetic variations in Tibetan populations and high-alti- tude adaptation at the Himalayas显示文摘 | Peng Y Yang Z Zhang H Cui C Qi X Luo X | 2011 | Mol Biol Evol2011，28，： | 1 |
| 18 | High-performance lithium battery anodes using silicon Nanowires显示文摘 | CHAN C K PENG H LIU G | | 0，，03： | 1 |
| 19 | Feature selection based on mutual information:Criteria of max-dependency,max-relevance,and min-redundancy显示文摘 | Peng H Long F Ding C | | 0，，08： | 1 |
| 20 | How increased VEGF induces glomerular hyperpermeability:a potential signaling pathway of Rac1 activation显示文摘 | Peng H Wang C Ye ZC | | 0，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员