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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Cloning and expression of functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv显示文摘 | Magalhaes M L B Pereira C P Basso L A | 2002 | Protein Expression and Purification2002，26，： | 2 |
| 3 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 4 | Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis显示文摘 | Claudia Fagundes Marie-No?lle Pépin Mónica Guevara Rogelio Barreto Gregori Casals Elsa Solà Gustavo Pereira Ezequiel Rodríguez Elisabet Garcia Verónica Prado Esteban Poch Wladimiro Jiménez Javier Fernández Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，2： | 2 |
| 5 | 显示文摘 | Arrabaca J D Amaral-Collaco M T | 1996 | International Biodeterioration & Biodegradation1996，，： | 1 |
| 6 | Activity of antioxidant en-zymes in response to cadmium in Crotalaria juncea显示文摘 | Pereira G J G Molina S M G Lea P J | 2002 | Plant andSoil2002，239，： | 1 |
| 7 | Risk of human exposure to paralytic loxlns of algal origin显示文摘 | Batoreu M C C Dias E Pereira P | 2005 | Environmental Toxicology and Pharmacology2005，19，： | 1 |
| 8 | Improved synthesis of benzotriazoles and 1-acylbenzotriazoles by ultrasound irradiation 显示文摘 | Pereira C M P Stefani H A Guzenc K P | 2007 | Letters in Organic Chemistry2007，4，1： | 1 |
| 9 | 查看详情显示文摘 | Louis B Ocampo F Yun H S Twssonnier J P Pereira M M | | 0，，： | 1 |
| 10 | Spread spectrum techniques in wireless communication显示文摘 | Pereira M Postolache O Girao P | 2009 | IEEE In- strumentation & Measurement Magazine2009，12，6： | 1 |
| 11 | Activity of antioxidant enzymes in response to cadmium in Crotalariajuncea显示文摘 | PEREIRA G J G MOLINA S M G LEA P J | 2002 | Plant and Soil2002，，239： | 1 |
| 12 | Effect of blood flow rate and donor vessel diameter on the patency of carotid venous bypass grafts in dogs显示文摘 | Pereira B M Weinstein P R Zea Longa E el-Fiki M | 1989 | Surg Neurol1989，31，： | 1 |
| 13 | Producao de biomassa e rizomas e incidência de 'Metsubure' em tarosubmetido a doses de potássio corn e sem adicao de cálcio显示文摘 | Pereira F H F Puiatti M Fontes P C R | 2006 | Horticultura Brasileira2006，24，1： | 1 |
| 14 | Mercury desorption from contaminated sediments显示文摘 | Duarte A C Pereira M E Oliveira J P Hall A | 1991 | Water Air and Soil Pollution1991，56，： | 1 |
| 15 | Construction of a RELP map in sorghum and comparative mapping in maize显示文摘 | Pereira M G Lee M Bramel-Cox P | 1994 | Genome1994，，37： | 1 |
| 16 | Aroma ageing trends in GC/MS profiles of liqueur wines显示文摘 | Pereira A C Reis M S Saraiva P M | 2010 | Anal Chim Acta2010，659，： | 1 |
| 17 | Miscibility, crystallinity and morphological behavior of binary blends of poly(ethylene oxide)and poly(methyl vinyl ether-maleic acid)显示文摘 | Rocco A M Pereira R P Felisberti M I | 2001 | Polymer2001，42，12： | 1 |
| 18 | Effect of the gamma radiation dose rate on psychrotrophic bacteria, thiobarbituric acid reactive substances, and sensory characteristics of mechanically deboned chicken meat 显示文摘 | Brito P P Azevedo H Cipolli K M Fukuma H T Moutao G B Roque C V Miya N T Pereira J L | 2011 | Journal of Food Science2011，76，2： | 1 |
| 19 | Severe cardiac failure associated wish presumed jellyfish sting Irukandji Syndrome显示文摘 | Little M Pereira P Mulcahy R | 2003 | Anaesth Intensive Care2003，31，： | 1 |
| 20 | Leech-derived thrombin inhibitors: From structures to mechanisms to clinical aspplications 显示文摘 | Corral-Rodriguez M Macedo-Ribeiro S Barbosa Pereira P | 2010 | J Med Chem2010，53，10： | 1 |
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