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| 1 | Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Obesity, hyperglycemia, type 2 diabetes and hypertriglyceridemia are the most important risk factors. The pathogenesis of NAFLD and its progression to fibrosis and chronic liver disease is still unknown. Accumulating evidence indicates that mitochondrial dysfunction plays a key role in the physiopathology of NAFLD, although the mechanisms underlying this dysfunction are still unclear. Oxidative stress is considered an important factor in producing lethal hepatocyte injury associated with NAFLD. Mitochondrial respiratory chain is the main subcellular source of reactive oxygen species(ROS), which may damage mitochondrial proteins, lipids and mitochondrial DNA. Cardiolipin, a phospholipid located at the level of the inner mitochondrial membrane, plays an important role in several reactions and processes involved in mitochondrial bioenergetics as well as in mitochondrial dependent steps of apoptosis. This phospholipid is particularly susceptible to ROS attack. Cardiolipin peroxidation has been associated with mitochondrial dysfunction in multiple tissues in several physiopathological conditions, including NAFLD. In this review, we focus on the potential roles played by oxidative stress and cardiolipin alterations in mitochondrial dysfunction associated with NAFLD. | Giuseppe Paradies Valeria Paradies Francesca M Ruggiero Giuseppe Petrosillo | 2014 | World Journal of Gastroenterology2014，20，39： | 50 |
| 2 | Indicating retrospective resilience of multi-scale patterns of real habitats in a landscape显示文摘 | G. Zurlini N. Zaccarelli I. Petrosillo | 2005 | Ecological Indicators2005，，1： | 2 |
| 3 | Colistin and Rifampicin Compared With Colistin Alone for the Treatment of Serious Infections Due to Extensively Drug-Resistant Acinetobacter baumannii: A Multicenter, Randomized Clinical Trial显示文摘 | Emanuele Durante-Mangoni Giuseppe Signoriello Roberto Andini Annunziata Mattei Maria De Cristoforo Patrizia Murino Matteo Bassetti Paolo Malacarne Nicola Petrosillo Nicola Galdieri Paola Mocavero Antonio Corcione Claudio Viscoli Raffaele Zarrilli Ciro Gal | 2013 | Clinical Infectious Diseases2013，，3： | 2 |
| 4 | Decrease in mitochondrial complex Ⅰ activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin显示文摘 | Paradies G Petrosillo G Pistolese M | 2004 | Circ Res2004，94，1： | 1 |
| 5 | Indicating fragility of socio-ecological tourism-based systems显示文摘 | Petrosillo I Zurlini G Grato E Zaccarelli N | 2006 | Ecological Indicators2006，6，1： | 1 |
| 6 | Indicating fragility of socio-ecological tourism-based systems显示文摘 | I. Petrosillo G. Zurlini E. Grato N. Zaccarelli | 2005 | Ecological Indicators2005，，1： | 1 |
| 7 | Epidemic muhidrug-re- sistant Acinetobacter baumannii related to European clonal types Ⅰ and Ⅱ in Rome(Italy) 显示文摘 | D'Arezzo S Capone A Petrosillo N | 2009 | Clin Microbiol Infect2009，15，4： | 1 |
| 8 | Modelling socio-ecological tourism-based systems for sustainability显示文摘 | Lacitignola D Petrosillo I Cataldi M Zurlini G | 2007 | Ecological Model-ling2007，206，12： | 1 |
| 9 | De- creased complex activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion :role of reac- tive oxygen species and cardiopin 显示文摘 | Petrosillo G Ruggiero FM Di Venosa N | 2003 | FASEB J2003，17，6： | 1 |
| 10 | Risk of exposure to blood bone infection for Italian health care workers by job category and work area显示文摘 | Puro V Carli GD Petrosillo N | 2001 | Infection Control of Hospital Epidemiol2001，22，4： | 1 |
| 11 | Time-dependent regimes of a tourism-based social-ecological system:Period-doubling route to chaos显示文摘 | Lacitignola D Petrosillo I Zurlini G | 2010 | Ecological Complexity2010，7，1： | 1 |
| 12 | Clinical manifestation of HIV related pulmonary hypertension显示文摘 | PETROSILLO N PELLICELLI A M BOUMIS E | 2001 | Ann N Y Acad Sci2001，946，11： | 1 |
| 13 | Prevalence of nosocomial infections in 15Italian hospitals:first point prevalance study for the INF-NOS project显示文摘 | Nicastri E Petrosillo N Martini L | 2003 | Infection2003，31，2： | 1 |
| 14 | The use of subjective indicators to assess how natural and social capital support residents’ quality of life in a small volcanic island显示文摘 | Irene Petrosillo Robert Costanza Roberta Aretano Nicola Zaccarelli Giovanni Zurlini | 2013 | Ecological Indicators2013，，： | 1 |
| 15 | Prevalanee of infected patients and understaffing have a role in hepatitis C virus transmission in dialysis显示文摘 | Petrosillo N Gilli P Serraino D | 2001 | Am J Kindey Dis2001，37，： | 1 |
| 16 | Frequency of detection of respiratory viruses in the lower respiratory tract of hospitalized adults显示文摘 | Minossc C Selleri M Zaniratti MS Cappiello G Longo R Schifano E Span6 A Petrosillo N Lauria FN Puro V Capobianchi MR | 2008 | J Clin Vriol2008，42，2： | 1 |
| 17 | Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation, possible role in the apoptosis显示文摘 | PETROSILLO G RUGGIERO F M PISTOLESE M | 2002 | FEBS Letters2002，509，： | 1 |
| 18 | Clinical experience of colistin-glycopeptide combination in critically ill patients in- fected with Gram0negative bacteria显示文摘 | Petrosillo N Giannella M Antonelli M | 2014 | Antimicrob Agents Che- mother2014，58，2： | 1 |
| 19 | Prevalence of infected patients and understaffing have a role in hepatitis C rirus tranmission in dialysis显示文摘 | Petrosillo N Gilli P Serraino D | 2001 | Am J Kidney Dis2001，37，： | 1 |
| 20 | Tourist perception of recreational environment and management in a marine protected area 显示文摘 | Petrosillo G Zurlini M E Corlianb N Zaeearelli M Dadamo | 2007 | Landscape and Urban Planning2007，，79： | 1 |
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