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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Tomographic measurement of local cerebral glucose metabolic rate in man with ^18F-2-fluoro-2-deoxy-D-glucose 显示文摘 | Phelps M E Huang S C Hoffman E J | 1979 | Annals of Neurology1979，6，5： | 1 |
| 3 | Viral marketing or electronic word - of- mouth advertising: examining consumer responses and moti- vatians to pass along email 显示文摘 | Phelps J E Lewis R Mobilio L | 2004 | Journal of adverstising research2004，，11： | 1 |
| 4 | Microfuel processor for use in a miniature power supply显示文摘 | Holladay J D Jones E O Phelps M | 2002 | Journal of Power Sources2002，108，12： | 1 |
| 5 | The Medium Run显示文摘 | BLANCHARD O J PHELPS E S | 1997 | Brookings Papers on Economic Activity1997，28，2： | 1 |
| 6 | Systems biology and new technologies enable predictive and pre- ventative medicine 显示文摘 | HOOD L HEATH J R PHELPS M E | 2004 | Science'' s STKE2004，306，5696： | 1 |
| 7 | Alkaline phosphatase histochemistry discriminates peritubular cells in primary rat testicular cell culture显示文摘 | CHAPIN R E PHELPS J L MILLER B E | 1987 | J Androl1987，8，3： | 1 |
| 8 | Survival of subsurface microorganisms exposed to UV radiation and hydrogen peroxide显示文摘 | ARRAGE A A PHELPS T J BENOIT R E | 1993 | Applied and Environmental Microbiology1993，59，11： | 1 |
| 9 | A unique combination of inflammatory cytokines enhances apoptosis of thyroid follicular cells and transforms nondestructive to destructive thyroiditis in experimental autoimmune thyroiditis显示文摘 | Wang S H Bretz J D Phelps E | 2002 | J Im- munol2002，168，5： | 1 |
| 10 | Error sensitivity of fluorodeoxyglucose method for measurement of cerebral metabolic rate of glucose 显示文摘 | Huang S C Phelps M E Hoffman E J | 1981 | Journal of Cerebral Blood Flow and Metabolism1981，1，4： | 1 |
| 11 | Microfuel processor for use in a miniature power supply 显示文摘 | Hollady J D Jones E O Phelps M | 2002 | J Power Sources2002，108，： | 1 |
| 12 | Does lym- phocystis occur in pacora, Plagioscion surinamensis (Sciaeni dae), from Colombia显示文摘 | Bunkley Williams L Williams E H J Phelps R P | 2002 | Acta Trop2002，82，1： | 1 |
| 13 | Systems biology and new technologies enable predictive and preventative medieine 显示文摘 | HOOD L HEATH J R PHELPS M E | 2004 | Science2004，306，5696： | 1 |
| 14 | Privacy concerns and consumer willingness to provide personal information 显示文摘 | Phelps J Nowak G Ferrell E | 2000 | Journal of Public Policy & Marketing2000，19，1： | 1 |
| 15 | Baeterial sensitivity to UV light as a model for ionizing radiation resistance显示文摘 | Arrage A A Phelps T J Benoit R E | 1993 | Jour-ral of Microbiological Methods1993，18，： | 1 |
| 16 | High-pressure steam drying:effects on permeability显示文摘 | Cutter B E Phelps J E | 1986 | For Prod J1986，36，6： | 1 |
| 17 | Neonatal phytoestrogen exposure alters oviduct mucosal immune response to pregnancy and affects preimplantation embryo development in the mouse 显示文摘 | Jefferson W N Padilla-Banks E Phelps J Y | 2012 | Biology of Reproduction2012，87，1： | 1 |
| 18 | The effect of pasture utilization rate on stocks of soil organic carbon and total nitrogen in a semi-arid tropical grassland显示文摘 | Pringle M J Allen D E Phelps D G | 2014 | Agriculture Ecosystems & Environment2014，195，： | 1 |
| 19 | Viral Marketing or Electron- ic Word-of-mouth Advertising: Examining Consumer Responses and Motivations to Pass along Email 显示文摘 | Phelps J E Lewis R Mobilio L | 2004 | Journal of Advertising Re- search2004，44，4： | 1 |
| 20 | The medium run显示文摘 | Blanchard O J Nordhaus W D Phelps E S | 1997 | Brookings Papers on Economic Activity1997，1997，2： | 1 |
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