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| 1 | Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction显示文摘AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modif ication of dietary protein source and calcium. METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomicanalyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform. RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites. CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied. | Taru K Pilvi Tuulikki Seppnen-Laakso Helena Simolin Piet Finckenberg Anne Huotari Karl-Heinz Herzig Riitta Korpela Matej Orei Eero M Mervaala | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 2 | Angiotensin II induces connective tissue growth factor gene expression via calcineurin- dependent pathways 显示文摘 | Piet F kaija I Juhani A | 2003 | Am J Pathol2003，163，1： | 1 |
| 3 | Angiotensin Ⅱ induces connective tissue growth factor gene expression via calcineurin-dependent pathways显示文摘 | PIET F KAIJA I JUHANI A | 2003 | Am J Pathol2003，163，： | 1 |
| 4 | Angiotensin II induces connec- tive tissue growth factor gene expression via calcineurin-depend- ent pathways 显示文摘 | Piet F Kaija I Juhani A | 2003 | Am J Pathol2003，163，： | 1 |
| 5 | Angiotensin Ⅱ induces connective growth factor expression via calcineurin-dependent pathways 显示文摘 | PIET F KAJIA I JUHANI A | 2003 | Am J Pathol2003，163，1： | 1 |
| 6 | Determination of molecular weight andsize distribution and branching characteristics of PVAc by means of sizeexclusion chromatography/multi-angle laser light scattering(SEC/MALLS)显示文摘 | SNEZANA G PETER S PIET I | 2004 | Polymer2004，45，： | 1 |
| 7 | Correlation of serum concent ration of tumor necrosis factor alpha,clinical course,ventilation and nonspecific bronchial hyperresponsiveness in patient s with isolated seasonal rhinitis and seasonal asthma显示文摘 | GRZELEWSKA-RZYMOWSKA I PIET RZKOWICZ M KROCZYNSKA | 2005 | Pol Merkuriusz Lek2005，18，： | 1 |
| 8 | A knowledge based system for reactor selection显示文摘 | RALPH J WOUTER N H J PIET I | 1996 | Computers and Chemical Engineering1996，20，： | 1 |
| 9 | connective tissue growth factor gene expression via calcineurin-dependent pathways显示文摘 | PIET F KAIJA I JUHANI A | 2003 | Am J Pathol2003，163，： | 1 |
| 10 | Angiotension II induces connective tissue growth factor gene expression via calcineurindependent pathways 显示文摘 | Piet F Kaija I Juhani A | 2003 | Am J Pathol2003，163，1： | 1 |
| 11 | Angiotension Ⅱ induces connective tissue growth factor gene expression via calcineurin-dependent pathways显示文摘 | Piet F Kaija I Juhani A | 2003 | Am J Pathol2003，163，1： | 1 |
| 12 | Control of glutamate clearance and synaptic effic'acy by glial coverage of neurons显示文摘 | Oiler SH Piet R Poulain I)A | | Seience0，292，5518： | 1 |
| 13 | 'Never eat in that restaurant, I did!': Exploring why people engage in negative word - of - mouth communication显示文摘 | Wetzer I M Zeelenberg M Piet ers R | 2007 | Psychology : Marketing2007，，8： | 1 |
| 14 | Connective tissue growth factor gene expression via calcineurin-dependent pathways显示文摘 | Kaija I Juhani A Saara M Marjut L Heikki V | 2003 | Am J Pathol2003，163，1： | 1 |
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