|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Primary prevention and treatment of venous thromboembolic events in patients with gastrointestinal cancers- Review显示文摘Venous thromboembolism event(VTE) is a common and morbid complication in cancer patients. Patients with gastrointestinal cancers often suffer from symptomatic or incidental splanchnic vein thrombosis, impaired liver function and/or thrombocytopenia. These characteristics require a thorough risk/benefit evaluation for individual patients. Considering the risk factors for the development of VTE and bleeding events in addition to recent study results may be helpful for correct initiation of primary pharmacological prevention and treatment of cancer-associated thrombosis(CAT), preferably with low molecular weight heparins(LMWH). Whereas thromboprophylaxis is most often recommended in hospitalized surgical and non-surgical patients with malignancy, there is less agreement as to its duration. With regard to ambulatory cancer patients, the lack of robust data results in low grade recommendations against routine use of anticoagulant drugs. Anticoagulation with LMWH for the first months is the evidence-based treatment for acute CAT, but duration of secondary prevention and the drug of choice are unclear. Based on published guidelines and literature, this review will focus on prevention and treatment strategies of VTE in patients with gastrointestinal cancers. | Hanno Riess Piet Habbel Anja Jühling Marianne Sinn Uwe Pelzer | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 9 |
| 2 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 3 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 4 | The prognostic value of histology in the assessment of patients with Budd–Chiari syndrome显示文摘 | Thjon J Tang Kenneth P Batts Piet C de Groen Bart van Hoek Elizabeth B Haagsma Wim C.J Hop Harry L.A Janssen | 2001 | Journal of Hepatology2001，，3： | 1 |
| 5 | Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats显示文摘 | Pietá Dias C Martins de Lima MN Presti-Torres J | | 0，，04： | 1 |
| 6 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 7 | Predition of peak oxygen uptake in men using pulmonary and hemodynamic variables during exercise显示文摘 | Bogaard H J H H Woltjer Anton R.J.Van Keimpema Piet E Postmus Peter M.J.M De Vries | | 0，，： | 1 |
| 8 | Extending the enterprise through multi - level supply control显示文摘 | Piet van Vlist Jurgen J E M Hoppembrouwers Herman M H Hegge | 1997 | International Journal of Production Economics1997，53，： | 1 |
| 9 | The importance of scale for fishing impact estimations 显示文摘 | Piet G J Quirijns F J | 2009 | Canadian Journal of Fisheries and Aquatic Science2009，66，： | 1 |
| 10 | On the galactosyl distribution of commercial galactomannans显示文摘 | Schols Henk A De Jongh | | Carbohydrate Polymers0，2052，4： | 1 |
| 11 | The impact of climate change and weather on transport: an overview of empirical findings 显示文摘 | Mark J K Piet R | 2009 | Transportation Research Part D: Transport and Environment2009，14，： | 1 |
| 12 | Detection of economically important viruses in boar semen by quantitative real-time PCR technologyl显示文摘 | Piet A Van Rijn Gerard J W | 2004 | Journal of Virological Methods2004，120，： | 1 |
| 13 | The Fibroneetin Binding Proteins of Staphylococcus aureus Are Requiredand Invasion of Bovine Mammary Gland Cells显示文摘 | Aart L Piet J M Nuijtenl | 1999 | FEMS Microbiology Lettres1999，1，180： | 1 |
| 14 | Synthesis,purification and characterization of cationic latices produced by the emulsion copolymerization of styrene with 3-(methacrylamidinopropyl)trimethylammonium chloride显示文摘 | Van Streun K H Belt W J Piet P | 1991 | Eur Polym J1991，27，9： | 1 |
| 15 | Cause and identification of taste and odour compounds in water显示文摘 | CEES B ZOETEMAN J PIET G J | 1974 | The Scienee of the Total Environment1974，3，1： | 1 |
| 16 | Molecular anal-ysis of ammonia-oxidizing bacteria of the p-subdivision ofthe class proteobacteria in compost and composted materials显示文摘 | George A K Naoumenko Z S Piet J L | 1999 | Appl Environ Microb1999，65，1： | 1 |
| 17 | A water-soluble diphosphine ligand with a large ‘natural' bite angle for two-phase hydroformylation of alkenes显示文摘 | MARCEL SCHREUDER GOEDHEIJT PAUL C J KAMER PIET W N M VAN LEEUWEN | 1998 | J Mol Catal A:Chem1998，134，： | 1 |
| 18 | Application of bacteriainvolved in the biological sulfur cycle for paper mill effluent purification 显示文摘 | Albert J H J Piet N L L Alfons J M S | 2009 | Science of the Total Environment2009，407，： | 1 |
| 19 | The Effect of Roads and Traffic on Hedgenhog (Erinaceus Europaeus) Populations 显示文摘 | Marcel P H Piet J M B | 2000 | Biological Conservation2000，95，： | 1 |
| 20 | Credit scoring for mi- crofinance:is it worth it? 显示文摘 | J ORIS V G WOUTER V PIET S etal | 2012 | International Journal of Finance Economics2012，17，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员