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| 1 | Key Management for High Bandwidth Secure Multicast 显示文摘 | Pietro R D Maneini L V Mei A | 2004 | Journal of Computer Security2004，，12： | 1 |
| 2 | Efficient and adaptive threshold signatures for adhoc networks 显示文摘 | PIETRO R D MANCINI L V ZANIN G | 2007 | Electronic notes in theoretical computer science2007，171，1： | 1 |
| 3 | Efficient and adaptive threshold signatures for Ad hoc networks 显示文摘 | Pietro R D Mancini L V and Zanin G | 2007 | Electronic Notes in Theoretical Computer Science2007，171，1： | 1 |
| 4 | Energy efficient node- to- node authentication and communication confidentiality in wireless sensor networks 显示文摘 | Pietro R D Mancini L V Mei A | 2006 | Wireless Netw2006，，12： | 1 |
| 5 | Efficient and AdaptiveThreshold Signatures for Ad hoc Networks显示文摘 | Pietro R D Mancini L V Zanin G | 2007 | Electronic Notes in Theoretical Computer Science(ENTCS)2007，171，1： | 1 |
| 6 | Clinical, biochemical and molecular diagnosis of a compound homozygote for the 254 bp deletion - 8 bp insertion of the APRT gene suffering from severe renal failure 显示文摘 | Pietro V D Perruzza I Amorini A M | 2007 | Clin Biochem2007，40，： | 1 |
| 7 | Comparative genomics of MAP kinase and culcium-calineurin signalling components in plant and human pathogenic fungi显示文摘 | Rispail N Soanes D Ant C Czajkowski R Grunler A Huguet R Perez NE Poli A Sartorel E Valiante V Yang M Beffa R Brakhage A Gow N Kahmann R Lebrun M Lenasi H Perez MJ Talbot N WendlandJ Pietro AD | 2009 | Fungal Genetics and Biology2009，46，4： | 1 |
| 8 | Security in wireless Ad - Hoc networks - a survey 显示文摘 | Pietro R D Guarino S Verde N V | 2014 | Computer Communications2014，40，10： | 1 |
| 9 | Distributed detec- tion of clone attacks in Wireless Sensor Networks显示文摘 | Conti M Pietro R D Mancini L V | 2011 | IEEE Transactions on Dependable and Secure Computing2011，8，5： | 1 |
| 10 | Evaluation of MODIS land surface temperature data to estimate air temperature in different ecosystems over Africa显示文摘 | Christelle V Pietro C Tufa D | 2010 | Remote Sensing of Environment2010，114，： | 1 |
| 11 | Synthesis and antioxi-dant activity of new homocarnosine beta-cyclodextrin conjugates显示文摘 | AMORINI A M BELLIA F PIETRO V D | 2007 | EurJ Med Chem2007，42，7： | 1 |
| 12 | Effieient and adaptive threshold signatures for ad hoe networks显示文摘 | Pietro R D Mancini L V Zanin G | 2007 | Electronic Notes in Theoretical Computer Science2007，171，： | 1 |
| 13 | Plasma C-reactive protein in hemodialysis patients : A cross-sectional, longitudinal clinical survey 显示文摘 | Paniehi V Migliori M Pietro D | 2000 | Blood Purif2000，18，1： | 1 |
| 14 | C-reactive protein and interleukin-6 levels are related to renal function in predialytic chronic renal failure 显示文摘 | PANICHI V MIGLIORI M D E PIETRO S | 2002 | Nephron2002，91，4： | 1 |
| 15 | Odor discrimination using adaptive resonance theory显示文摘 | Cosimo D Pietro S Lorenzo V | 2000 | Sensors and Actuators B2000，69，： | 1 |
| 16 | Security and privacy issues of handheld and wearable devices 显示文摘 | PIETRO D MANCINI R L V | 2003 | Communications of the ACM2003，46，9： | 1 |
| 17 | On the reconstruction of three - dimensional protein structures from contact maps显示文摘 | Pietro D L Marco V Luciano M | 2009 | Algorithms2009，2，1： | 1 |
| 18 | Polymorphism AGT2(rs4762)is involved in the development of dermatologic events:Proof-of-concept in hepatocellular carcinoma patients treated with sorafenib显示文摘BACKGROUND Dermatologic adverse events(DAEs)are associated with a better outcome in patients with hepatocellular carcinoma(HCC)irrespective of the therapeutic agent received.The exact mechanisms associated with the development of DAEs are unknown although several studies point to direct toxicity of tyrosine kinase inhibitors(TKIs)to the skin or an immune-mediated reaction triggered by the oncologic treatment.As is the case in other conditions,individual genetic variants may partially explain a higher risk of DAEs.AIM To evaluate the contribution of several gene variants to the risk of developing DAEs in HCC patients treated with TKIs.METHODS We first analyzed 27 single-nucleotide polymorphisms(SNPs)from 12 genes selected as potential predictors of adverse event(AE)development in HCC patients treated with sorafenib[Barcelona Clinic Liver Cancer 1(BCLC1)cohort].Three additional cohorts were analyzed for AGT1(rs699)and AGT2(rs4762)polymorphisms-initially identified as predictors of DAEs:BCLC2(n=79),Northern Italy(n=221)and Naples(n=69)cohorts,respectively.The relation between SNPs and DAEs and death were assessed by univariate and multivariate Cox regression models,and presented with hazard ratios and their 95%confidence intervals(95%CI).RESULTS The BCLC1 cohort showed that patients with arterial hypertension(AHT)(HR=1.61;P value=0.007)and/or AGT SNPs had an increased risk of DAEs.Thereafter,AGT2(rs4762)AA genotype was found to be linked to a statistically significant increased probability of DAEs(HR=5.97;P value=0.0201,AA vs GG)in the Northern Italy cohort by multivariate analysis adjusted for BCLC stage,ECOG-PS,diabetes and AHT.The value of this genetic marker was externally validated in the cohort combining the BCLC1,BCLC2 and Naples cohorts[HR=3.12(95%CI:1.2-8.14),P value=0.0199,AGT2(rs4762)AA vs AG genotype and HR=2.73(95%CI:1.18-6.32)P value=0.0188,AGT2(rs4762)AA vs GG genotype].None of the other gene variants tested were found to be associated with the risk of DAE development.CONCLUSION DAE development in HCC patients receiving TKIs could be explained by the AGT2(rs4762)gene variant.If validated in other anti-oncogenic treatments,it might be considered a good prognosis marker. | Víctor Sapena Massimo Iavarone Loreto Boix Floriana Facchetti Maria Guarino Marco Sanduzzi Zamparelli Alessandro Granito Esther Samper Mario Scartozzi Josep Corominas Giorgia Marisi Alba Díaz Andrea Casadei-Gardini Laura Gramantieri Pietro Lampertico Filomena Morisco Ferran Torres Jordi Bruix María Reig | 2022 | World Journal of Hepatology2022，14，7： | 0 |
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