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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Masnou-Seeuws F Photoassociation in a Gas of Cold Alkali Atoms : Ⅰ-Perturbative Auantum Approach 显示文摘 | PILLET P CRUBELLIER A BLETON A | 1997 | Phys B At Mol Opt Phys1997，30，： | 1 |
| 3 | Efficacy of cyclosporine A in the treatment of macrophage activation syndrome in juvenile arthritis:report of five cases显示文摘 | Mouy R Stephan JL Pillet P | 1996 | J Pediatr1996，129，5： | 1 |
| 4 | Surgicatreatment of nonaneurysmal aortic arch lesions in patients withsystemic embolization显示文摘 | Goueffic Y Chaillou P Pillet JC | 2002 | J Vasc Surg2002，36，： | 1 |
| 5 | 查看详情显示文摘 | Ga(e)tan A Miroshnychenko Y Wilk T Chotia A Viteau M Comparat D Pillet P Browaeys A Grangier P | | 0，，： | 1 |
| 6 | 查看详情显示文摘 | Comparat D Pillet P | | 0，，： | 1 |
| 7 | Pedicle screw placement using image-guided techniques显示文摘 | Merloz P Tonetti J Pillet L | 1998 | Clin Orthop1998，354，： | 1 |
| 8 | VvGOLS1 and VvHsfA2 are involved in the heat stress responses in Grapevine Berries显示文摘 | Pillet J Egert A Pieri P | 2012 | Plant and Cell Physiology2012，53，10： | 1 |
| 9 | Efficacy of cyclosporine A in the treatment of macrophage activation syndrome in juvenile rheumatoid arthritiS: report of five cases显示文摘 | Mouy R Stephan J-L Pillet P | 1996 | J Pediatr1996，129，5： | 1 |
| 10 | Inside-outside duality for planar billiards:numerical study 显示文摘 | DIETZ B ECKMANN J P PILLET C A | 1995 | Phys Rev E1995，51，： | 1 |
| 11 | Observation of Near-infrared Dicke Superradiance on Cascading Transitions in Atomic Sodium显示文摘 | GROSS M FABRE C PILLET P | 1976 | Phys Rev Lett1976，36，： | 1 |
| 12 | Efficacy of cyclosporine a in the treatment of macrophage activation syndrome in juvenile arthritis: report of five cases 显示文摘 | Mouy R Stephan J L Pillet P | 1996 | J Pediatr1996，129，5： | 1 |
| 13 | Efficacy of cyclosporine A in the treatment of macrophage activation syndrome in juvenile arthritis:report of five cases显示文摘 | Mouy R Stephan JL Pillet P | 1996 | J Pediatr1996，129，5： | 1 |
| 14 | Pedicle screw placement using image-guide techniques显示文摘 | MERLOZ P TONETTI J PILLET L | 1998 | Clin Orthop1998，354，： | 1 |
| 15 | Congenital tuberculosis : difficulties in early diagnosis显示文摘 | Pillet P Grill J Rakotonirina G | 1999 | Arch Pediatr1999，6，： | 1 |
| 16 | A randomized controlled trial of endovascular aneurysm repair versus open surgery for abdominal aortic aneurysms in low-to moderate-risk patients显示文摘 | BECQEMIN J P PILLET J C LESCALIE F | 2011 | J Vasc Surg2011，53，： | 1 |
| 17 | Radio-anatomical study of the arteries of the foot显示文摘 | Albaret P Pillet J Guntz M | 1975 | Bull Assoc Anat (Nancy)1975，59，： | 1 |
| 18 | 查看详情显示文摘 | PILLET N SANDULESCU N SCHUCK P | | 0，，： | 1 |
| 19 | 查看详情显示文摘 | VINAS X SCHUCK P PILLET N | | 0，，： | 1 |
| 20 | Pedicle screw placement using image-guided techniques显示文摘 | Merloz P Tonetti J Pillet L | 1998 | Clin Orthop1998，354，： | 1 |
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