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| 1 | Delaying surgery after neoadjuvant chemoradiotherapy improves prognosis of rectal cancer显示文摘AIM To investigate the prognostic effect of a delayed interval between neoadjuvant chemoradiotherapy(CRT) and surgery in locally advanced rectal cancer.METHODS We evaluated 87 patients with locally advanced mid-or distal rectal cancer undergoing total mesorectal excision following an interval period after neoadjuvant CRT at ?i?li Hamidiye Etfal Training and Research Hospital,Istanbul between January 2009 and January 2014.Patients were divided into two groups according to the intervalbefore surgery: < 8 wk(group Ⅰ) and ≥ 8 wk(group Ⅱ).Data related to patients,cancer characteristics and pathological examination were collected and analyzed.RESULTS When the distribution of timing between group Ⅰ(n = 45) and group Ⅱ(n = 42) was viewed,comparison of interval periods(median ± SD) of groups showed a significant difference of as 5 ± 1.28 wk in group Ⅰ and 10.1 ± 2.2 wk in group Ⅱ(P < 0.001).The median follow-up period for all patients was 34.5(9.9-81) mo.group Ⅱ had significantly higher rates of pathological complete response(p CR) than group Ⅰ had(19% vs 8.9%,P = 0.002).Rate of tumor regression grade(TRG) poor response was 44.4% in group Ⅰ and 9.5% in group Ⅱ(P < 0.002).A poor pathological response was associated with worse disease-free survival(P = 0.009).The interval time did not show any association with local recurrence(P = 0.79).CONCLUSION Delaying the neoadjuvant CRT-surgery interval may provide nodal down-staging,improve p CR rate,and decrease the rate of TRG poor response. | Mehmet Mihmanli Esin Kabul Gürbulak Ismail Ethem Akgün Mustafa Fevzi Celayir Pinar Yazici Deniz Tuncel Tuba Tülin Bek Ayhan Oz Sinan Omeroglu | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 3 |
| 2 | Determination of serologic markers against bacterial atypical pneumonia agents in pneumonia patients显示文摘 | Pinar A Ercis S Ulukavak T | 2004 | Mikrobiyol Bul2004，38，12： | 1 |
| 3 | The emissions from a space-heating biomass stove 显示文摘 | KOYUNCU T PINAR Y | 2007 | Biomass and Bioenergy2007，31，1： | 1 |
| 4 | Severe hyponatremia due to escitalopram treatment in an elderly adult with Alzheimer' s disease显示文摘 | Pinar M D Isik A T | 2014 | J Am Geriat Society2014，62，12： | 1 |
| 5 | Depolarization of radiation by non-absorbing foams显示文摘 | Basil T Wong M Pinar Menguc | 2002 | Journal of Quantitative Spectroscopy & Radiative Transfer2002，，73： | 1 |
| 6 | Rapid detection of bacterial atypical pneumonia agents by multiplex PCR显示文摘 | Pinar A Bozdemir N Kocagz T | 2004 | Cent Eur J Public Health2004，12，1： | 1 |
| 7 | The efficacy of preopoerative instruction in reducing anxiety following gyneoncologlcal surgery:a case control study 显示文摘 | Pinar G Kurt A Gungor T | 2011 | World journal of surgical oncology2011，9，1： | 1 |
| 8 | Characterization and adsorption properties of chemically modified sepiolite显示文摘 | YASEMIN T PINAR T MEHMET D | 2008 | Industrial & Engineering Chemistry Research2008，47，6： | 1 |
| 9 | Dynamic flux balanceanalysis for pharmaceutical protein production by Pichia pastoris :Human growth hormone 显示文摘 | Pinar C Merve S Hatice T | 2011 | Journal of Biotechnology2011，48，3： | 1 |
| 10 | Discrete- Dipole Approximation With Surface Interaction: Compu- tational Toolbox for MATLAB 显示文摘 | Loke V L Y Pinar Mengii M Nieminen T A | 2011 | Journal of Quantita- tive Spectroscopy and Radiative Transfer2011，112，11： | 1 |
| 11 | Characterization and adsorption properties of chemically modified sepiolite 显示文摘 | Yasemin T Pinar T Mehmet D | 2008 | Ind Eng Chem Res2008，47，6： | 1 |
| 12 | BCL-2, in combination with MVP and IGF-1R expression, improves prediction of clinical outcome in complete response cervical carcinoma patients treated by radiochemotherapy显示文摘 | Henr l quez-Hern t ndez LA Lloret M Pinar B | 2011 | Gynecol Onc- ol2011，122，3： | 1 |
| 13 | Determination of serologic markers against bacterial atypical pneumonia agents in pneumonia patients显示文摘 | Pinar A Erois S Ulukavak T | 2004 | Mikrobiyol Bul2004，38，12： | 1 |
| 14 | The efficacy of preopoerative instruction in reducing anxiety following gyneoncological surgery:a case control study显示文摘 | Pinar G Kurt A Gungor T | 2011 | World journal of surgical oncology2011，9，1： | 1 |
| 15 | An in-depth analysis of stochastic Kronecker graphs 显示文摘 | SESHADHRI C PINAR A KOLDA T G | 2013 | Journal of the ACM2013，60，2： | 1 |
| 16 | Determination of serologic markers against bacterial atypical pneumonia agents in pneumonia patients显示文摘 | Pinar A Ercis S Ulukavak T | 2004 | Mikrobiyol Bul2004，38，12： | 1 |
| 17 | Determination of serologic markers against bacterial atypical pneumonia agents in pneumonia patients显示文摘 | Pinar A Ercis S Ulukavak T | 2004 | Mikrobiyol Bul2004，38，12： | 1 |
| 18 | Synthesis of the aluminophosphate ICP-1 by self-assembly of 1,3-diphenylguanidine:Insights into supramolecular aggregation显示文摘 | Á lvaro-Muñ oz T Pinar A B Š iš ak D | 2014 | J Phys Chem C2014，118，9： | 1 |
| 19 | Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy显示文摘AIM:To determine the relationship between proliferative diabetic retinopathy(PDRP) and plasma coenzyme Q10 CoQ10 concentration.METHODS:Patients with type 2 diabetes and PDRP were determined to be the case group(n=50).The control group was consist of healthy individuals(n=50).Plasma CoQ10 and malondialdehyde(MDA) levels were measured in both groups.RESULTS:Ubiquinone-10(CoenzymeQ10)levelsinPDRP and control subjects are 3.81±1.19μmol/L and 1.91±0.62μmol/L,respectively.Plasma MDA levels in PDRP and control subjects were 8.16±2μmol/L and 3.44±2.08μmol/L,respectively.Ratio of Ubiquinol-10/ubiquinone-10 in PDRP and control subjects were 0.26±0.16 and 1.41±0.68,respectively.CONCLUSION:The ratio of ubiquinol-10/ubiquinone10 is found lower in patients with PDRP.High levels of plasma ubiquinol-10/ubiquinone-10 ratio indicate the protective effect on diabetic retinopathy. | Orhan Ates Habip Bilen Sadullah Keles H.Hakan Alp Mevlüt Sait Keles Kenan Yildirim Osman ndas L.Can Pinar Mustafa Civelekler Orhan Baykal | 2013 | International Journal of Ophthalmology(English edition)2013，6，5： | 0 |
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