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| 1 | Regulation of Phosphate Starvation Responses in Plants: Signaling Players and Cross-Talks显示文摘磷酸盐(Pi ) 可获得性是限制植物的生长,开发,和生产率的一个主要因素。在生态、农业的上下文,植物经常与低可溶的磷酸盐内容在土壤成长。植物由一系列发展、新陈代谢的改编回答针对从土壤增加这重要营养素的获得到这种状况,以及种生长和幸存支撑。植物怎么察觉到磷酸盐缺乏并且经由表明小径协调回答的全面理解的开发有降临到主要兴趣,和很多个发信号的播放器和网络开始为磷酸盐缺乏反应的规定出现了。在实践,如此的知识的申请被复杂串音妨碍改进植物 Pi 营养,它在面临新数据时是新兴的,例如表明有涉及荷尔蒙的那些的网络的磷酸盐缺乏的协作,相片吸收(糖),象与另外的离子的动态平衡一样,例如铁。在这评论,我们在发现涉及 Pi 饥饿回答的新发信号的播放器集中于这些串音并且在最近的进步上,例如有 SPX 域的蛋白质。 | Hatem Rouached A. Bulak Arpat Yves Poirier | 2010 | Molecular Plant2010，3，2： | 28 |
| 2 | Galectin-3 Mediates Aldosterone-Induced Vascular Fibrosis显示文摘 | Laurent Calvier Maria Miana Pascal Reboul Victoria Cachofeiro Ernesto Martinez-Martinez Rudolf A. de Boer Fran?oise Poirier Patrick Lacolley Faiez Zannad Patrick Rossignol Natalia López-Andrés | 2013 | Arteriosclerosis, Thrombosis, and Vascular Biology2013，，1： | 2 |
| 3 | Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer显示文摘17β-hydroxysteroid dehydrogenase(17β-HSD)type 1 is known as a critical target to block the final step of estrogen production in estrogen-dependent breast cancer.Recent confirmation of the role of dyhydroxytestosterone(DHT)in counteracting estrogeninduced cell growth prompted us to study the reductive 17β-HSD type 7(17β-HSD7),which activates estrone while markedly inactivatingDHT.The role ofDHTin breast cancer cell proliferation isdemonstratedby its independent suppression of cell growthin the presence of a physiological concentration of estradiol(E2).Moreover,an integral analysis of a large number of clinical samples in Oncomine datasets demonstrated the overexpression of 17β-HSD7 in breast carcinoma.Inhibition of 17β-HSD7 in breast cancer cells resulted in a lower level of E2 and a higher level of DHT,successively induced regulation of cyclinD1,p21,Bcl-2,and Bik,consequently arrested cell cycle in the G0/G1 phase,and triggered apoptosis and auto-downregulation feedback of the enzyme.Such inhibition led to significant shrinkage of xenograft tumors with decreased cancer cell density and reduced 17β-HSD7 expression.Decreased plasma E2 and elevated plasma DHT levels were also found.Thus,the dual functional 17β-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of E2 andDHT.Thisdemonstrates aconceptual advance on the general belief that the major role of this enzyme is in cholesterol metabolism. | Xiaoqiang Wang Catherine Gérard Jean-Francois Thériault Donald Poirier Charles J.Doillon Sheng-Xiang Lin | 2015 | Journal of Molecular Cell Biology2015，7，6： | 2 |
| 4 | Biological profiles in subjects with recurrent acute coronary events compared with subjects with long-standing stable angina 显示文摘 | BOGATY P POIRIER P SIMARD S | 2001 | Circulation2001，103，25： | 2 |
| 5 | 解密世界的方程式显示文摘这是一个神奇的公式!施之于各个领域,它能提供答案,带来发现,提示真相。更神奇的是,神经学家认为它可以为我们开启认知人类思维方式的大门! | Mathilde Fondez Roman lkonicoff Boris Bellanger Florenza Gracci Lassagne Herve Poirier Emilie Rauscher 王佳(编译) | 2013 | 新发现2013，，2： | 2 |
| 6 | Micromechanics applied to the thermal shock behavior of refractory ceramics显示文摘 | N. Schmitt A. Burr Y. Berthaud J. Poirier | 2002 | Mechanics of Materials2002，，11： | 2 |
| 7 | 一种直列式6缸发动机主轴承盖的开发显示文摘将粉末冶金用于铝合金发动机汽缸体意味着对材料切削加工性能的一种挑战。除了要求静态与疲劳强度之外,为了能够对发动机汽缸体组件进行有效地镗孔,材料的切削加工性状还必须和铝合金相容。为了满足这项应用提出的要求,开发了含有六方氮化硼的粉末配方。这项重要发展包括材料选择、切削性评价,以及静态与动态强度试验。为确定轴承盖最关键的部位进行了有限元分析(FEA)。轴承盖是在经过金相检验、尺寸变化测定、静态与疲劳试验之后,进行制造与鉴定的。对制造工艺提出并实行了一些改进。轴承盖顺利地进行了切削加工,并通过了用户的发动机试验。此后,这些轴承盖在数以百万件计地进行生产。 | Edmond Ilia Mike O’Neill Jordan Lee Joel Poirier Sylvain St-Laurent 韩凤麟 | 2007 | 粉末冶金技术2007，25，4： | 2 |
| 8 | Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction显示文摘 | Cambien F Poirier O Lecerf L | 1992 | Nature1992，359，： | 1 |
| 9 | The prospective role of abnormal methyl metabolism in cadmium toxicity 显示文摘 | POIRIER L A VLASOVA T I | 2002 | Environ Health Perspect2002，110，5： | 1 |
| 10 | Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease显示文摘 | Blankenberg S Rupprecht HJ Poirier O | 2003 | Circulation2003，107，12： | 1 |
| 11 | Extensive association analysis between the CETP gene and coronary heart disease phenotypes reveals several putative functional polymorphisms and gene-environmental interaction 显示文摘 | Corbex M Poirier Fumeron F | 2000 | Genet Epidemiol2000，19，： | 1 |
| 12 | Beta fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction, the ECTIM Stuty显示文摘 | Poirier O Nicaud V | 1996 | Circulation1996，93，3： | 1 |
| 13 | Surgical treatment of aortic hypoplasia in infants and children with biventricular hearts显示文摘 | Van Arsdell GS Brindle M | 1999 | Ann Thorac Surg1999，68，6： | 1 |
| 14 | Diastolic dysfunction in normotensive men with well-controlled type2 diabetes:importance of maneuvers in echocardiographic screening for preclinical diabetic cardiomyopathy显示文摘 | Poirier P Bogaty P Garneau C | 2001 | Diabetes Care2001，24，1： | 1 |
| 15 | Diastolic dysfunction in normotensive men with well-controlled type 2 diabetes:importance of maneuvers in echocardiographic screening for preclinical diabetic cardiomyopathy显示文摘 | Poirier P Bogaty P Garneau C | 2001 | Diabetes Care2001，24，1： | 1 |
| 16 | A comparative study of the corona performance of conductor bundles for 1200 kV transmission lines显示文摘 | Trinh N Giao Maruvada P Sarma Poirier Benny | 1974 | IEEE Trans on Power Appar syst1974，93，3： | 1 |
| 17 | Treatment With 1 -- alpha, 25-- clihydroxyvitamin D3 (vitamin D3) to inhibit ear cinogenesis in the hamster buceal pouch model 显示文摘 | Meier J D Enepekides D J Poirier B | 2007 | Arch Oto- laryngol Head Neck Surg2007，133，11： | 1 |
| 18 | Power and Temperature Control on a 90nm Itanium Family Processor显示文摘 | McGowen R Poirier C A Bostak C | 2006 | Journal of Solid-State Circuits2006，，： | 1 |
| 19 | Venlafaxine and paroxetine in treatment-resistant depression显示文摘 | Poirier MF Boyer P | 1999 | Br J Psychiatry1999，175，： | 1 |
| 20 | The polymorphism in exon3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease显示文摘 | Beffert U Arguin C Poirier J | 1999 | Neurosci Lett1999，259，： | 1 |
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