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| 1 | Coronary artery disease in congenital single coronary artery in adults:A Dutch case series显示文摘AIM:To assess the current diagnostic and therapeutic management and the clinical implications of congenital single coronary artery(SCA) in adults.METHODS:We identified 15 patients with a SCA detected from four Dutch angiography centers in the period between 2010 and 2013.Symptomatic patients who underwent routine diagnostic coronary angiography(CAG) for suspected coronary artery disease and who incidentally were found to have isolated SCA were analyzed.RESULTS:Fifteen(7 females) with a mean age of 58.5 ± 13.78 years(range 43-86) had a SCA.ConventionalCAG demonstrated congenital isolated SCA originating as a single ostium from the right sinus of Valsalva in 6 patients and originating from the left in 9 patients.Minimal to moderate coronary atherosclerotic changes were found in 4,and severe stenotic lesions in another 4 patients.Seven patients were free of coronary atherosclerosis.Runs of non-sustained ventricular tachycardia were documented in 2 patients,one of whom demonstrated transmural ischemic changes on presentation.Myocardial perfusion scintigraphic evidence of transmural myocardial ischemia was found in 1 patient due to kinking and squeezing of the SCA with an interarterial course between the aorta and pulmonary artery.Multi-slice computed tomography(MSCT) was helpful to delineate the course of the anomalous artery relative to the aorta and pulmonary artery.Percutaneous coronary intervention was successfully performed in 3 patients.Eight patients were managed medically.Arterial bypass graft was performed in 4 patients with the squeezed SCA.CONCLUSION:SCA may be associated with transient transmural myocardial ischemia and aborted sudden death in the absence of coronary atherosclerosis.The availability and sophistication of MSCT facilitates the delineation of the course of a SCA.We present a Dutch case series and review of the literature. | Salah AM Said Willem G de Voogt Suat Bulut Jacques Han Peter Polak Rogier LG Nijhuis Jeroen W op den Akker Andries Slootweg | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 2 | REGULATION OF HUMAN RETINAL BLOOD FLOW BY ENDOTHELIN-1显示文摘There is evidence from in vitro and animal studies that endothelin is a major regulator of retinal blood flow. We set out to characterize the role of the endothelin-system in the blood flow control of the human retina. Two studies in healthy subjects were performed. The study design was randomized, placebo-con- | Polak A.Luksch B.Frabk E.Polska L.Schmetterer | 2003 | 国际眼科杂志2003，3，1： | 2 |
| 3 | Genetics of congenital hypothyroidism: Modern concepts显示文摘Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder and one of the most common preventable causes of intellectual disability in the world. CH may be due to developmental or functional thyroid defects (primary or peripheral CH) or be hypothalamic-pituitary in origin (central CH). In most cases, primary CH is caused by a developmental malformation of the gland (thyroid dysgenesis, TD) or by a defect in thyroid hormones synthesis (dyshormonogenesis, DH). TD represents about 65% of CH and a genetic cause is currently identified in fewer than 5% of patients. The remaining 35% are cases of DH and are explained with certainty at the molecular level in more than 50% of cases. The etiology of CH is mostly unknown and may include contributions from individual and environmental factors. In recent years, the detailed phenotypic description of patients, high-throughput sequencing technologies, and the use of animal models have made it possible to discover new genes involved in the development or function of the thyroid gland. This paper reviews all the genetic causes of CH. The modes by which CH is transmitted will also be discussed, including a new oligogenic model. CH is no longer simply a dominant disease for cases of CH due to TD and recessive for cases of CH due to DH, but a far more complex disorder. | Athanasia Stoupa Dulanjalce Kariyawasam Michel Polak Aurore Carre | 2022 | Pediatric Investigation2022，6，2： | 2 |
| 4 | Role of nitric oxide in the control of ocular blood flow 显示文摘 | Schmetterer L Polak K | 2001 | Prog Retin Eye Res2001，20，6： | 1 |
| 5 | A unified steerable phase i-phase ii method of feasible directions for semi-infinite optimization显示文摘 | POLAK E HE L | 1991 | J Optim Theory Appl1991，69，1： | 1 |
| 6 | The 3D object reconstruction form 2D slieesimage preprocessing显示文摘 | Fano M Polak M | 2000 | The Central European Seminaron Computer Graphics2000，5，： | 1 |
| 7 | Carotid artery in tima and media thickness as a riskfactor for myoeardia linfaretion and stroke in older adnhs显示文摘 | O' Leafy DH Polak JF Kronmal RA etal | 1999 | N Engl J Med1999，340，： | 1 |
| 8 | Lung cancer detection: results of a randomized prospective study in Czechoslovakia 显示文摘 | Kubik A Polak J | 1986 | Cancer1986，57，12： | 1 |
| 9 | Thickening of the carotid wall:a marker for atherosclerosis in the elderly?Cardiovascular Health Study Collaborative Research Group显示文摘 | O'Leary DH Polak JF Kronmal RA | 1996 | Stroke1996，27，： | 1 |
| 10 | Blood Dyscrasia Attributed to Chloramphenicol显示文摘 | Meyer L Polak BCP Shut D | 1974 | Postgrad Med1974，50，： | 1 |
| 11 | Carotid endarterectomy:Preoperativeevaluation of candidates with combined doppler sonography and MR angiography显示文摘 | Polak GF Kalina B Donaldso MC, | 1993 | Radiology1993，186，： | 1 |
| 12 | Third-generation biomedical materials显示文摘 | Hench L L Polak J M | 2002 | Science2002，295，5557： | 1 |
| 13 | Myocardial infarction withnormal coronary arteriogram:the role of ephedrine-like alkaloids显示文摘 | Grzesk G Polak G Grabczewska Z | 2004 | Med Sci Monit2004，10，4： | 1 |
| 14 | Cash and working capital management in the Czech republic显示文摘 | Polak P Kocurek K | | 0，，01： | 1 |
| 15 | The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia显示文摘 | Polak R Buitenhuis M | 2012 | Blood2012，119，4： | 1 |
| 16 | Management strategies forneonatal hypoglycemia 显示文摘 | Sweet CB Grayson S Polak M | 2013 | J Pediatr Pharmacol Ther2013，18，3： | 1 |
| 17 | Pantoprazole in severe acid-peptic disease: the effectiveness and safety of 5 years’ continuous treatment显示文摘 | K.D. Bardhan A.E. Bishop J.M. Polak H.M. Romanska A. Rowland M. Thompson P. Morris S. Schaefer-Preuss R. Luehmann B. McCaldin | 2004 | Digestive and Liver Disease2004，，1： | 1 |
| 18 | Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults 显示文摘 | O' LEARY DH POLAK JF KRONMAL RA | 1999 | N Engl J Med1999，340，： | 1 |
| 19 | Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis显示文摘 | Mulder JW Wielenga VJ Polak MM | 1995 | Cut1995，36，5： | 1 |
| 20 | Derivation of distal lung epithelial progenitors from murine embryonic stem cells using a novel three-step differentiation protocol显示文摘 | Rippon HJ Polak JM Qin M | 2006 | Stem Cells2006，24，5： | 1 |
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