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| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Omission of Nitrous Oxide from a Propofol Based Anesthetic does not Affect the Recovery of Women Undergoing Outpatient Gynecologic Surgery显示文摘 | ARELLANO R J POLE M L RAFUSE S E | 2000 | Anesthesiology2000，93，2： | 1 |
| 3 | Omission of nitrous oxidefrom a propofol-hased anesthetic dose not affest the recovery of women undergoing outpatient gynecologic J显示文摘 | AB rellano R J Pole M L Rafuse S E | 2000 | Anesthesiology2000，93，2： | 1 |
| 4 | HIV-induced is associated with colonization of the proximal gut by environmental bacteria显示文摘 | Yang L Poles M A Fisch G S | 2016 | AIDS2016，30，1： | 1 |
| 5 | The process of end-of-life care delivery to the families of elderly patients accordingto the Family Health Strategy显示文摘 | Silva L Poles K Baliza M F | 2013 | Rev Lat Am Enfer-magem2013，21，1： | 1 |
| 6 | Omissin of nitrouso xide from a propofol,based anesthetic does not affect the recovery of women undergoing ocetpatient gynecologic surgery显示文摘 | BARELLANO R J POLE M L RAFUSE S E | 2002 | Anesthesiology2002，93，2： | 1 |
| 7 | Evaluation ofrunaway reaction for dicumyl peroxide in a batch reactor by DSC and VSP2 显示文摘 | Wu S H Shyu M L Yet Pole 1 | 2009 | Journal of Loss Prevention in the Process Industries2009，22，6： | 1 |
| 8 | Dose-sparing H5N1 A/Indonesia/05/2005 pre-pandemic influenza vaccine in adults and elderly adults:a phase Ⅲ,placebo-controlled,randomized study显示文摘 | Langley J M Risi G Caldwell M Gilderman L Berwald B Fogarry C Poling T RiffD Bar | | 0，，12： | 1 |
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