|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Omission of Nitrous Oxide from a Propofol Based Anesthetic does not Affect the Recovery of Women Undergoing Outpatient Gynecologic Surgery显示文摘 | ARELLANO R J POLE M L RAFUSE S E | 2000 | Anesthesiology2000，93，2： | 1 |
| 3 | Cerebral injury during cardiopulmonary bypass : emboli impair memory 显示文摘 | Feam S J Pole R Wesnes K | 2001 | J Thorac cardiovasc surg2001，121，6： | 1 |
| 4 | Nitrification modelling in biofilms under inhibitory conditions 显示文摘 | Gheewala S H Pole R K Armachhatre A P | 2004 | Water Research2004，38，1415： | 1 |
| 5 | Chemical regulation of carotenoid biosynthesis, Part 10: Chemical induction of 13 carotene biosynthesis 显示文摘 | Poling S M Hsu W J Koehrn F J | 1977 | Photochemistry1977，16，5： | 1 |
| 6 | Acylated flavonoids in cullus cultures of Citrus aurantifolia显示文摘 | Berhow M A Nennett R D Poling S M | 1994 | Phytochemistry1994，36，5： | 1 |
| 7 | Primary HIV-1 infection is associated with preferential depletion of CD4^+ T lym- phocytes from effector sites in the gastrointestinal tract显示文摘 | Mehandru S Poles MA Tenner-Racz K | 2004 | J Exp Med2004，200，： | 1 |
| 8 | Renal deterioration in myelodysplastic children:urodynamic evaluation and clinical correlates显示文摘 | Kurzrock EA Poles S | 1998 | J Urol1998，159，5： | 1 |
| 9 | Influence of fall nitrogen and spring nitrogen-potassium applications on yield and fruit quality of ' Chadler' strawberry 显示文摘 | Miner G S Poling E B Carrol D E | 1997 | J Amer Soc Hort Set1997，122，2： | 1 |
| 10 | A molecular phylogeny of reptiles显示文摘 | Hedges S B Poling L L | 1999 | Science1999，283，： | 1 |
| 11 | Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling显示文摘 | Kubin T Poling J Kostin S | 2011 | Cell Stem Cell2011，9，5： | 1 |
| 12 | Cesarean section : does it really prevent the development of postpartum stress urinary incontinence? A prospective study of 363 women one year after their first delivery 显示文摘 | Groutz A Rimon E Poled S | 2004 | Neurourol Urodyn2004，23，： | 1 |
| 13 | Nitric oxide protects, endothelial cells from tummor necrosis factora mediated cytotoxicity : Possible involvement of cyclic GMP显示文摘 | Pole T Oberle S Schroder H | 1997 | FEBS Lett1997，409，： | 1 |
| 14 | Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection 显示文摘 | Vasan S Poles MA Horowitz A Siladji EE Markowitz M Tsuji M | 2007 | Int Irnmunol2007，19，8： | 1 |
| 15 | Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension显示文摘 | PHILLIPS J A POLING J S PHILLIPS C A | 2008 | Genet Med2008，10，5： | 1 |
| 16 | Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage显示文摘 | Yokoyama S Feige E Poling LL | 2008 | Pigment Cell Melanoma Res2008，21，： | 1 |
| 17 | Mechanisms of gastrointestinal CD4 +T cell depletion during acute and early human immunodefieiency virus type 1 infection显示文摘 | Mehandm S Poles MA Tenner-Racz K | | 0，，02： | 1 |
| 18 | Prima ry HIV-1 infection is associated with preferential depletion of CD4^+ T lymphocytes from effector sites in the gastrointestinal tract显示文摘 | Mehandru S Poles M A Tenner-Racz K | 2004 | J Exp Med2004，200，： | 1 |
| 19 | Docosahexaenoic acid block of neuronal voltage-gated K + channels:subunit selective antagonism by zinc显示文摘 | Poling JS Vicini S Rogawski MA | 1996 | Neuropharmacology1996，35，： | 1 |
| 20 | Primary HIV-1 infection is associated with preferential depletion of CD4^+ T lym- phocytes from effector sites in the gastrointestinal tract显示文摘 | Mehandru S Poles MA Tenner-Racz K | 2004 | J Exp Med2004，200，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员