|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Challenge of liver disease in systemic lupus erythematosus:Clues for diagnosis and hints for pathogenesis显示文摘Systemic lupus erythematosus(SLE) encompass a broad spectrum of liver diseases. We propose here to classify them as follows:(1) immunological comorbilities(overlap syndromes);(2) non-immunological comorbilities associated to SLE; and(3) a putative liver damage induced by SLE itself, referred to as 'lupus hepatitis'. In the first group, liver injury can be ascribed to overlapping hepatopathies triggered by autoimmune mechanisms other than SLE occurring with higher incidence in the context of lupus(e.g., autoimmune hepatitis, primary biliary cirrhosis). The second group includes non-autoimmune liver diseases, such as esteatosis, hepatitis C, hypercoagulation state-related liver lesions, hyperplasic parenchymal and vascular lesions, porphyria cutanea tarda, and drug-induced hepatotoxicity. Finally, the data in the literature to support the existence of a hepatic disease produced by SLE itself, or the occurrence of a SLE-associated prone condition that increases susceptibility to acquire other liver diseases, is critically discussed. The pathological mechanisms underlying each of these liver disorders are also reviewed. Despite the high heterogeneity in the literature regarding the prevalence of SLE-associated liver diseases and, in most cases, lack of histopathological evidence or clinical studies large enough to support their existence, it is becoming increasingly apparent that liver is an important target of SLE. Consequently, biochemical liver tests should be routinely carried out in SLE patients to discard liver disorders, particularly in those patients chronically exposed to potentially hepatotoxic drugs. Diagnosing liver disease in SLE patients is always challenging, and the systematization of the current information carried out in this review is expected to be of help both to attain a better understanding of pathogenesis and to build an appropriate work-up for diagnosis. | Ferno Bessone Natalia Poles Marcelo G Roma | 2014 | World Journal of Hepatology2014，6，6： | 7 |
| 2 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 3 | In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression显示文摘 | Maria Cecilia G Marcondes Matthew Poling | 2008 | Cellular Immunol2008，254，： | 1 |
| 4 | Investigation on protection of metal corrosion inhibitors of propargyl alcohols显示文摘 | Poling G W | 1967 | J Electrochem Soc1967，114，： | 1 |
| 5 | Clinical measures of au- ditory function: the cochlea and beyond显示文摘 | Baiduc R R Poling G L Hong O | 2013 | Dis Mon2013，59，4： | 1 |
| 6 | Blood Lactate during Exercise:Time Course of Training Adaptation in Humans显示文摘 | GAESSER G A POLE D C | 1988 | Int J Sports Med1988，9，： | 1 |
| 7 | Infrared studies of protective films formed by acetylenic corrosion inhibitors 显示文摘 | Poling G W | 1987 | Electrochem Soc1987，114，： | 1 |
| 8 | Influence of fall nitrogen and spring nitrogen-potassium applications on yield and fruit quality of ' Chadler' strawberry 显示文摘 | Miner G S Poling E B Carrol D E | 1997 | J Amer Soc Hort Set1997，122，2： | 1 |
| 9 | Brief postnatal PBDE exposure alters learning and the cholinergic modulation of attention in rats 显示文摘 | Dufault C Poles G Driscoll LL | 2005 | Toxicol Sci2005，88，1： | 1 |
| 10 | The Role of Dithiolates in the Flotation of Sulfide Minerals显示文摘 | Finkestein N P Poling G W | 1977 | Miner Sci Eng1977，9，4： | 1 |
| 11 | Use a Navier-Stokes code in understanding tilt-rotor flow- fields in hover显示文摘 | Poling D R Rosenstein H Raiagopalan G | 1998 | Journal of the American Helicop- ter Society1998，43，2： | 1 |
| 12 | Reflection infrared studies of films formed by benzotriazole显示文摘 | Poling G W | 1970 | Corrosion Science1970，10，： | 1 |
| 13 | A study of the surface oxidation of arsenopyrite using cyclic voltammetry 显示文摘 | Beattie M J V Poling G W | 1987 | International Journal of Mineral Processing1987，20，12： | 1 |
| 14 | Corrosion inhibition of copper with benzotriazole显示文摘 | OGLE I C G POLING G W | 1975 | Can Met Quart1975，，14： | 1 |
| 15 | Corrosion pretreatments for copper-zinc alloys显示文摘 | NOTOYA T | 1979 | Corrosion1979，35，： | 1 |
| 16 | Corrosion inhibition of copper with benzotriazole显示文摘 | POLING G W | 1975 | Canadian Metallurgical Quarterly1975，14，： | 1 |
| 17 | HIV-induced is associated with colonization of the proximal gut by environmental bacteria显示文摘 | Yang L Poles M A Fisch G S | 2016 | AIDS2016，30，1： | 1 |
| 18 | Reflection infrared studies of film formed by benzotriazole on copper显示文摘 | Poling G W | 1970 | Corros Sci1970，172，10： | 1 |
| 19 | Topographies of thick Cu benzotriazolete Friars on copper 显示文摘 | Notoya T Poling G W | 1976 | Corros Sci1976，32，8： | 1 |
| 20 | Intrinsic positive end expirato-ry pressure ( PEEPi) 显示文摘 | Russian Poles G Brandi G | 1995 | Intensive Care Med1995，21，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员