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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Inflammation in irritable bowel syndrome:Myth or newtreatment target?显示文摘Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome(IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications describing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanisms underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism. | Emanuele Sinagra Giancarlo Pompei Giovanni Tomasello Francesco Cappello Gaetano Cristian Morreale Georgios Amvrosiadis Francesca Rossi Attilio Ignazio Lo Monte Aroldo Gabriele Rizzo Dario Raimondo | 2016 | World Journal of Gastroenterology2016，22，7： | 16 |
| 3 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 4 | Matemal-conceptus cross talk-a review 显示文摘 | Vigano P Mangioni S Pompei F | 2003 | Placenta2003，24，： | 1 |
| 5 | The natural history of deliriumin older hospitalized patients:A syndrome of heterogeneity 显示文摘 | Rudberg Peter Pompei | 1997 | Age and Aging1997，26，3： | 1 |
| 6 | High-performance liquid chromatographic assay for meropenem in serum显示文摘 | Elkhaili H Niedergang S Pompei D etal | 1996 | J Chromatogr B Biomed Appl1996，686，1： | 1 |
| 7 | A new method ofclassifying prognostic comorbidity in longitudinal studies : developmentand validation 显示文摘 | Charlson ME Pompei P Ales KL | 1987 | Journal of Chronic Diseases1987，40，5： | 1 |
| 8 | High-performance liquid chromatographic assay for meropenem in serum显示文摘 | Elkhaili H Niedergang S Pompei D | 1996 | J Chromatogr(B)1996，686，： | 1 |
| 9 | Post-thoracotomy analgesia: epidural versus intravenous morphine continuous infusion 显示文摘 | Delia RG Coccia C Pompei L | 2002 | Mi- nerva Anesthesiology2002，68，9： | 1 |
| 10 | Goal-directed therapy in anesthesia: any clinical impact or just a fashion? 显示文摘 | Della Rocca G Pompei L | 2011 | Minerva Anestesiol2011，77，5： | 1 |
| 11 | Changes in some egg components and analytical values due to hen age显示文摘 | Rossi M Pompei C | 1995 | Poultry science1995，74，： | 1 |
| 12 | A new surgical technique for the correction of theinverted nipple显示文摘 | Pompei S Tedesco M | 1999 | Aesth Plast Surg1999，23，： | 1 |
| 13 | In situ hybridization analysis of preprotachykinin-A mRNA levels in young and old rats显示文摘 | Pompei P Severini R Costa G | 1999 | Mol Brain Res1999，64，： | 1 |
| 14 | Continuous and intermittent cardiac output measurement: pulmonary artery catheter versus aortic transpulmonary technique 显示文摘 | Rocca DG Costa MG Pompei L | 2002 | Br J Anaesth2002，88，3： | 1 |
| 15 | Antioxidant properties of potentially probiotic bacteria:in vitro and in vivo activities显示文摘 | Alberto Amaretti Mattia di Nunzio Anna Pompei | 2013 | Appl Microbiol Bioteehnol2013，97，： | 1 |
| 16 | A new method ofclassify prognostic comorbidity in longitudinal studies: de-velopment and validation 显示文摘 | Charlson M E Pompei P Ales K L | 1987 | Journal of Chronic Disease1987，40，5： | 1 |
| 17 | Post-thoracotomy analgesia:epidural vs intravenous morphine continuous infusion显示文摘 | Della Rocca G Ceccia C Pompei L | 2002 | Minerva Anestesiol2002，68，9： | 1 |
| 18 | Antiviral properties of glycyrrhizic acid and its semisynthetic derivative 显示文摘 | Pompei R Laconi S Ingianni A | 2009 | Mini Rev Med Chem2009，9，8： | 1 |
| 19 | An embedded portable biosensor system for bacterial concentration detection显示文摘 | GROSSI M LANZONI M POMPEI A | | 0，，03： | 1 |
| 20 | A new method of classifyingprognostic comorbidity in longitudinal studies: development and validation 显示文摘 | CHARLSON ME POMPEI P ALES KL | 1987 | J Chronic Dis1987，40，5： | 1 |
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