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| 1 | Eubiotic properties of rifaximin: Disruption of the traditional concepts in gut microbiota modulation显示文摘Antibiotics are usually prescribed to cure infections but they also have significant modulatory effects on the gut microbiota. Several alterations of the intestinal bacterial community have been reported during antibiotic treatment, including the reduction of beneficial bacteria as well as of microbial alpha-diversity. Although after the discontinuation of antibiotic therapies it has been observed a trend towards the restoration of the original condition, the new steady state is different from the previous one, as if antibiotics induced some kind of irreversible perturbation of the gut microbial community. The poorly absorbed antibiotic rifaximin seem to be different from the other antibiotics, because it exerts non-traditional effects additional to the bactericidal/bacteriostatic activity on the gut microbiota. Rifaximin is able to reduce bacterial virulence and translocation, has anti-inflammatory properties and has been demonstrated to positively modulate the gut microbial composition. Animal models, culture studies and metagenomic analyses have demonstrated an increase in Bifidobacterium, Faecalibacterium prausnitzii and Lactobacillus abundance after rifaximin treatment, probably consequent to the induction of bacterial resistance, with no major change in the overall gut microbiota composition. Antibiotics are therefore modulators of the symbiotic relationship between the host and the gut microbiota. Specific antibiotics, such as rifaximin, can also induce eubiotic changes in the intestinal ecosystem; this additional property may represent a therapeutic advantage in specific clinical settings. | Francesca Romana Ponziani Maria Assunta Zocco Francesca D’Aversa Maurizio Pompili Antonio Gasbarrini | 2017 | World Journal of Gastroenterology2017，23，25： | 17 |
| 2 | Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications显示文摘Liver cirrhosis is a paradigm of intestinal dysbiosis. The qualitative and quantitative derangement of intestinal microbial community reported in cirrhotic patients seems to be strictly related with the impairment of liver function. A kind of gut microbial 'fingerprint',characterized by the reduced ratio of 'good' to 'potentially pathogenic' bacteria has recently been outlined,and is associated with the increase in Model for End-Stage Liver Disease and Child Pugh scores. Moreover,in patients presenting with cirrhosis complications such as spontaneous bacterial peritonitis(SBP),hepatic encephalopathy(HE),and,portal hypertension intestinal microbiota modifications or the isolation of bacteria deriving from the gut are commonly reported. Rifaximin is a non-absorbable antibiotic used in the management of several gastrointestinal diseases. Beyond bactericidal/bacteriostatic,immune-modulating and anti-inflammatory activity,a little is known about its interaction with gut microbial environment. Rifaximin has been demonstrated to exert beneficial effects on cognitive function in patients with HE,and also to prevent the development of SBP,to reduce endotoxemia and to improve hemodynamics in cirrhotics. These results are linked to a shift in gut microbes functionality,triggering the production of favorable metabolites. The low incidence of drug-related adverse events due to the small amount of circulating drug makes rifaximin a relatively safe antibiotic for the modulation of gut microbiota in advanced liver disease. | Francesca Romana Ponziani Viviana Gerardi Silvia Pecere Francesca D'Aversa Loris Lopetuso Maria Assunta Zocco Maurizio Pompili | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 3 | Underwater acoustic sensor networks: research challenges 显示文摘 | AKYILDIZ I F POMPILI D OMELOA T | 2005 | AdHo Networks2005，3，3： | 1 |
| 4 | Underwater acoustic sensor networks: Research challenges 显示文摘 | AKYILDIZ I F POMPILI D MELODIA T | 2005 | Elsevier Journal of Ad Hoe Networks2005，3，3： | 1 |
| 5 | Underwater acoustic sensor networks:Research challenges显示文摘 | Akyildiz I Pompili D Melodia T | | 0，，03： | 1 |
| 6 | A CDMA-based medium access control protocol for underwater acoustic sensor networks显示文摘 | POMPILI D MELODIA T AKYILDIZ I F | 2009 | IEEE Transactions on Wireless Communications2009，8，4： | 1 |
| 7 | Psychiatric comorbility in patientswith chronic daily headache and migraine:A selective overviewincluding personality traits and suicide risk显示文摘 | Pompili M Daniela D C Marco I | 2009 | Headache Pain2009，10，4： | 1 |
| 8 | Underwater Acoustic Sensor Networks: Research Challenges 显示文摘 | Akyildiz I F Pompili D Melodia T | 2005 | Ad Hoc Networks2005，3，3： | 1 |
| 9 | Underwater acoustic sensor networks: Research challenges显示文摘 | Akyildiz I F Pompili D Melodia T | 2005 | Ad-hoc Networks(Elsevier)2005，3，3： | 1 |
| 10 | Underwater acoustic sensor net- works:research challenges 显示文摘 | Akyildiz I F Pompili D Melodia T | 2005 | Ad Hoc Networks ( S1570-8705 )2005，3，3： | 1 |
| 11 | Underwater a- coustic sensor networks: Research challenges显示文摘 | Akyildiz I F Pompili D Melodia T | 2005 | Ad Hoc Networks (Elsevier)2005，3，3： | 1 |
| 12 | Dynamic Collaboration Between Networked Robots and Clouds in Resource-Constrained Environments显示文摘 | Pandey P Pompili D Yi J | 2015 | IEEE Transactions on Automation Science & Engineering2015，12，2： | 1 |
| 13 | Underwater acoustic sensor networks:research challenges显示文摘 | AKYILDIZ I F POMPILI D MELODIA T | 2005 | Ad Hoc Networks2005，3，3： | 1 |
| 14 | Underwater acoustic sensor networks: research challenges 显示文摘 | Akyildiz I F Pompili D Melodia T | 2005 | Ad Hoc Networks Journal2005，3，3： | 1 |
| 15 | Challenges for efficient communication in underwater acoustic sensor networks显示文摘 | AKYILDIZ I F POMPILI D MELODIA T | 2004 | ACM SIGBED Review2004，1，2： | 1 |
| 16 | Expression and function of a recombinant PDGF B gene in porcine arteries显示文摘 | Gordon D San H | 1995 | Arterioscler Thromb Vasc Biol1995，15，12： | 1 |
| 17 | Underwater acoustic sensor networks:research challenges显示文摘 | Akyildiz I F Pompili D Melodia T | 2005 | Ad Hoc Networks Journal2005，，3： | 1 |
| 18 | The state of the art in cross-layer design for wireless sensor networks 显示文摘 | Melodia T Vuran M C Pompili D | 2006 | Springer Lecture Notes in Computer Seienee2006，3883，1： | 1 |
| 19 | Under - water acoustic sensornetworks : research ch - allenges显示文摘 | I F Akyildiz D Pompili T Melodia | 2005 | Ad Hoc Networks ( S1570 -8705)2005，3，3： | 1 |
| 20 | Underwater acoustic sen-sor networks : Research challenges 显示文摘 | AKYILDIZ I F POMPILI D MELODIA T | 2005 | Ad hoc Networks2005，3，3： | 1 |
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