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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | 显示文摘 | Jimenez de Haro M C Perez-Rodriguez J L Poyato J | 2005 | Applied Clay Science2005，30，1： | 1 |
| 3 | Effect of the concentration of suspended solids on the enzymatic activities and biodiversity of a submerged membrane bioreactor for aerobic treatment of domestic wastewater显示文摘 | M Molina-Munoz J M Poyatos R Vilchez | 2007 | Appl MicrobiolBiotechnol2007，73，6： | 1 |
| 4 | Automatic generation of consensus ground truth for the comparison of edge detection techniques显示文摘 | Garcia N L F Poyato A C Carnicer R M | 2008 | Image and Vision Computing2008，26，4： | 1 |
| 5 | Advanced oxidation processes for wastewater treatment : state of the art 显示文摘 | Poyatos J M Munio M M Almecija M C | 2010 | Water Air and Soil Pollution2010，205，1234： | 1 |
| 6 | Complexes with poly(N-heterocyclic carbene) ligands:structural features and catalytic applications显示文摘 | POYATOS M MATA J A PERIS E | | 0，，08： | 1 |
| 7 | Comparative analysis of the bacterial diversity in a lab-scale moving bed biofilm reactor (MBBR) applied to treat urban wastewater under different operational conditions 显示文摘 | CALDERON K MARTfN-PASCUAL J POYATOS J M | 2012 | Bioresour Teehnol2012，10，121： | 1 |
| 8 | Microbial community structure and dynamics in a pilot-scalesubmerged membrane bioreactor aerobically treating domesticwastewater under real operation conditions 显示文摘 | MOLINA-MUOZ M POYATOS J M SANCHEZ- PEINADO M | 2009 | Science of the Total Environment2009，4，7： | 1 |
| 9 | Catalysed low temperature H2 release from nitrogen heterocycles 显示文摘 | Moores A Poyatos M Yi L | 2006 | New Journal of Chemistry2006，30，11： | 1 |
| 10 | A classification method of alternatives for multiple preference ordering criteria based on fuzzy majority显示文摘 | Chiclana F Herrera F Herrera-Viedma E Poyatos M C | 1996 | Journal of Fuzzy Mathematics1996，4，： | 1 |
| 11 | Compositional and structural study of ferroeleetric multiplayer (Pb,La)TiO3/(Pb,Ca)TiO3 sol-gel thin films显示文摘 | Calzada M L | 2004 | Journal of the European Ceramic Society2004，，24： | 1 |
| 12 | Structural and catalytic properties of chelating his-and tris-N-heterocyclic carbenes显示文摘 | Mata J A Poyatos M Peris E | 2007 | Coord Chem Rev2007，251，： | 1 |
| 13 | Effects of substrate annealing and post-crystallization thermal treatments on the functional properties of preferentially oriented (Pb,Ca)TiO3 thin filrns显示文摘 | POYATO R CALZADA M L PARDO L | 2003 | J Appl Phys2003，93，： | 1 |
| 14 | Advanced oxi- dation processes for wastewater treatment: state of the art显示文摘 | Poyatos J M Almecija M C Torres J C | 2010 | Water Air Soil Pollut2010，205，14： | 1 |
| 15 | Advanced Oxidation Processes for Wastewater Treatment: State of the Art显示文摘 | Poyatos J M Almecija M C | 2010 | Water Air Soil Pollution2010，205，14： | 1 |
| 16 | Catalysed low temperature H2 release from nitrogen heterocycles 显示文摘 | MOORES A POYATOS M YI L | 2006 | New J Chem2006，30，11： | 1 |
| 17 | Comparative analysis of the bacterial diversity in a lab-scale moving bed biofilm reactor (MBBR) applied to treat urban wastewater under different operational conditions 显示文摘 | CALDERON K MARTIN P J POYATOS J M | 2012 | Bioresource Technology2012，121，： | 1 |
| 18 | A clas-sification method of altematiVes for multiple preference ordering cri-teria based on fuzzy majority显示文摘 | Herrera F Herrera-Viedma E Poyatos M C | 1996 | Journal of Fuzzy Mathematics1996，4，： | 1 |
| 19 | Advanced oxidation processes for wastewater treatment: state of the art显示文摘 | Poyatos J M Almecija M C Tortes J C | 2010 | Water Air & Soil Pollution2010，205，14： | 1 |
| 20 | Complexes with Poly (N-heterocyelic earbene) Ligands: Structural Features and Catalytic Applications 显示文摘 | POYATOS M MATA J A PERIS E | 2009 | Chem Rev2009，109，8： | 1 |
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