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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | Morphological Control for High Performance, Solution-Processed Planar Herterojunc-tion Perovskite Solar Cells显示文摘 | Giles E Victor M B Pablo D | 2014 | Advanced Functional Materials2014，24，1： | 1 |
| 3 | Topical antibacterial therapy for acne显示文摘 | Fulton J E Pablo G Fla M | 1974 | Arch Dermatol1974，110，： | 1 |
| 4 | Shooting Seismic Surveys in Circles 显示文摘 | Buia M Flores Pablo E Hill D | 2008 | Oilfield Review2008，20，3： | 1 |
| 5 | Regularized extreme learning machine for regression problems 显示文摘 | JOS M M PABLO E M EMILIO S O | 2011 | Neurocomputing2011，74，17： | 1 |
| 6 | Preparation of Sb2S3 nanostruc- tures by the ionic liquid assisted low power sonochemical method显示文摘 | Pablo S E Eduard M S | 2010 | Mater Lett2010，64，23： | 1 |
| 7 | Molecular epidemiology of tuberculosis:current insights显示文摘 | Barun M Natalia E K Pablo J B | 2006 | Clin Microbiol Rev2006，19，4： | 1 |
| 8 | Development of a multianalyte method based on mi- cro-matrix-solid-phase dispersion for the analysis of fragrance allergens and preservatives in personal care products显示文摘 | CELEIRO M GUERRA E PABLO LAMAS J | 2014 | Journal of Chromatography A2014，1344，： | 1 |
| 9 | Residual Fluxes in a Cross-section of the Valdivia River Estuary,Chile显示文摘 | Mario Pino Q Perillo G M E Pablo Santamarina | 1994 | Estuarine Coastal and Shelf Science1994，，38： | 1 |
| 10 | Prediction of the hemoglo-bin levee in hemodialysis patients using machine 显示文摘 | Jose M Pablo E Carlo B | 2014 | Computer Methods and Programs in Bio- medicine2014，117，2： | 1 |
| 11 | Remitting seronegative symmetrical synovitis with pitting edema associated with subcutaneous Streptobacillus moniliformis abscess显示文摘 | Torres A Cuende E De Pablos M | 2001 | J Rheumatol2001，28，7： | 1 |
| 12 | Improved routing strategies for Internet traffic delivery显示文摘 | Pablo E Jesds G G Yamir M | 2004 | Physical Review E2004，70，05： | 1 |
| 13 | Cup-to-disk ratio asymmetry: diagnostic value in glaucoma显示文摘 | Polo Llorens V Larrosa Poves J M Pablo Julvez L E | 2002 | Arch Soc Esp Oftalmol2002，77，1： | 1 |
| 14 | Chro-nic inflamma-tion and inceased arterial stiffness in pa-tients with cardiac syndrome X显示文摘 | ARROYO E R NADIA M PABLO A | 2003 | Eur Heart J2003，24，： | 1 |
| 15 | May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson\'s disease? 显示文摘 | Fernández E García-Moreno J M Martín de Pablos A Chacón J | 2013 | Antioxid Redox Signal2013，19，： | 1 |
| 16 | Relevance of dietary lipids as modulators of immune functions incells infected with Listeria monocytogenes显示文摘 | Pueflollano M A de Pablo M A Alvarez D E | 2002 | Clin Diagn Lab Immunol2002，9，2： | 1 |
| 17 | Thrombin induces in vivo degeneration of nigral dopaminergic neurons along with the activation of microglia 显示文摘 | CARRENO-MIJLLER E HERRERA A J DE PABLOS R M | 2003 | Neurochem2003，84，5： | 1 |
| 18 | Sunflower Protein Concentrates and Isolates Prepared from Oil Cakes Have High Water Solubility and Antioxidant Capacity显示文摘 | Pablo R Salgado S E M O | 2011 | (88): 351-3602011，，88： | 1 |
| 19 | Serum IGF-1 binding Protein is related to IGF-1, but not to spontaneous GH release in healthy old men显示文摘 | Pablo F Copas E S Harman S M | 1990 | Endocrine Rev1990，11，： | 1 |
| 20 | Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study显示文摘 | Mary Eapen Pablo Rubinstein Mei-Jie Zhang Cladd Stevens Joanne Kurtzberg Andromachi Scaradavou Fausto R Loberiza Richard E Champlin John P Klein Mary M Horowitz John E Wagner | 2007 | The Lancet . 2007 (9577)2007，，9577： | 1 |
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