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| 1 | 安徽石台县日本血吸虫病传染源调查显示文摘目的了解石台县血吸虫病传染源种类,指导当地防治工作。方法选择龙泉、垄上及源头3个流行村,开展人畜及野生动物的病原学查病,计算感染率及感染度。结果3个村感染日本血吸虫的宿主有人、狗、猫及野鼠,其中人感染率分别为0、1.01%和0.87%,野鼠和狗感染率分别在22.22~33.33%和4.35~26.47%。感染度以野鼠最高,达609.91(算术均数)和259.06(几何均数)。并在当地另一乡发现1只野兔感染血吸虫。结论当地血吸虫病流行可能与野鼠、狗等有关,但明确各种感染宿主在血吸虫病传播中的地位尚有待分子生物学研究。 | 吕大兵 汪天平 James Rudge 孙爱炎 方国仁 吴维铎 吴明耀 朱磊 汪峰峰 章乐生 操治国 Joanne Webster | 2007 | 热带病与寄生虫学2007，5，1： | 24 |
| 2 | Harmful algal blooms and eutrophication: 'strategies' for nutrient uptake and growth outside the Redfield comfort zone显示文摘While many harmful algal blooms have been associated with increasing eutrophication, not all species respond similarly and the increasing challenge, especially for resource managers, is to determine which blooms are related to eutrophication and to understand why particular species proliferate under specific nutrient conditions. The overall goal of this brief review is to describe why nutrient loads are not changing in stoichiometric proportion to the 'Redfield ratio', and why this has important consequences for algal growth. Many types of harmful algae appear to be able to thrive, and/or increase their production of toxins, when nutrient loads are not in proportion classically identified as Redfield ratios. Here we also describe some of the physiological mechanisms of different species to take up nutrients and to thrive under conditions of nutrient imbalance. | Patricia M. GLIBERT JoAnn M. BURKHOLDER | 2011 | Chinese Journal of Oceanology and Limnology2011，29，4： | 21 |
| 3 | Design and 3D Printing of Scaffolds and Tissues显示文摘A growing number of three-dimensional(3D)-print- ing processes have been applied to tissue engineering. This paper presents a state-of-the-art study of 3D-printing technologies for tissue-engineering applications, with particular focus on the development of a computer-aided scaffold design system; the direct 3D printing of functionally graded scaffolds; the modeling of selective laser sintering(SLS) and fused deposition modeling(FDM) processes; the indirect additive manufacturing of scaffolds, with both micro and macro features; the development of a bioreactor; and 3D/4D bioprinting. Technological limitations will be discussed so as to highlight the possibility of future improvements for new 3D-printing methodologies for tissue engineering. | Jia An Joanne Ee Mei Teoh Ratima Suntornnond Chee Kai Chua | 2015 | Engineering2015，1，2： | 21 |
| 4 | Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?显示文摘Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability.Therapeutic hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;however,many infants still experience lifelong disabilities to movement,sensation and cognition.Clinical guidelines,based on strong clinical and preclinical evidence,recommend therapeutic hypothermia should be started within 6 hours of birth and continued for a period of 72 hours,with a target brain temperature of 33.5 ±0.5℃ for infants with moderate to severe hypoxic-ischemic encephalopathy.The clinical guidelines also recommend that infants be re warmed at a rate of 0.5℃ per hour,but this is not based on strong evidence.There are no randomized controlled trials investigating the optimal rate of rewarming after therapeutic hypothermia for infants with hypoxic-ischemic encephalopathy.Preclinical studies of rewarming are conflicting and results were confounded by treatment with sub-optimal durations of hypothermia.In this review,we evaluate the evidence for the optimal start time,duration and depth of hypothermia,and whether the rate of rewarming after treatment affects brain injury and neurological outcomes. | Anthony Davies Guido Wassink Laura Bennet Alistair J.Gunn Joanne O.Davidson | 2019 | Neural Regeneration Research2019，14，10： | 20 |
| 5 | Renal drug transporters and their significance in drug–drug interactions显示文摘The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites.Renal drug transporters,which are primarily located in the renal proximal tubules,play an important role in tubular secretion and reabsorption of drug molecules in the kidney.Tubular secretion is characterized by high clearance capacities,broad substrate specificities,and distinct charge selectivity for organic cations and anions.In the past two decades,substantial progress has been made in understanding the roles of transporters in drug disposition,efficacy,toxicity and drug–drug interactions(DDIs).In the kidney,several transporters are involved in renal handling of organic cation(OC) and organic anion(OA) drugs.These transporters are increasingly recognized as the target for clinically significant DDIs.This review focuses on the functional characteristics of major human renal drug transporters and their involvement in clinically significant DDIs. | Jia Yin Joanne Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 19 |
| 6 | 疼痛对乳腺癌患者生活质量影响调查显示文摘目的了解乳腺癌患者的疼痛感受和生活质量状况,评估疼痛对生活质量的影响程度。方法采用中国人癌症疼痛评估工具(Chinese Cancer Pain Assessment Tool,CCPAT)和生活质量调查问卷(第3版)[EORTIC QLQ-C30(Version 3)]对200例乳腺癌患者进行横断面设计的面对面问卷调查。结果200例乳腺癌患者中有疼痛者84例(42%),无疼痛者116例(58%)。疼痛组患者疼痛评分高于非疼痛组患者评分(P<0.001)。疼痛组患者在生活质量的躯体功能领域、角色功能领域和社会功能领域的评分低于无疼痛组患者,其差异有统计学意义(P<0.05);两组患者在生活质量的情绪功能领域、认知功能领域和整体生活质量的评分差异无统计学意义(P>0.05);疼痛组患者的疼痛评分与整体生活质量评分呈显著负相关(r=–0.731,P<0.001)。结论疼痛对乳腺癌患者的躯体功能、角色功能和社会功能有一定的负面影响;患者受疼痛的冲击加重时,其整体生活质量降低。 | 王世平 马玲 Joanne Chung | 2008 | 中国循证医学杂志2008，8，4： | 16 |
| 7 | 复发性流产患者NK细胞毒性和子宫动脉血流灌注对妊娠结局的影响显示文摘目的:探讨复发性流产(RPL)患者NK细胞毒性和子宫动脉血流灌注对妊娠结局的影响。方法:回顾分析162例RPL患者的临床资料,根据妊娠结局分为流产组(n=30)和分娩组(n=132),比较两组的NK细胞毒性和子宫动脉血流阻力指数(U-RI)变化。结果:流产组的孕前NK细胞毒性高于分娩组,差异有统计学意义(P=0.02),两组的孕前U-RI比较差异无统计学意义(P=0.12);早孕期流产组各孕周的NK细胞毒性均高于分娩组,但差异无统计学意义(P〉0.05)。U-RI在早孕期较孕前明显降低(P〈0.001),且分娩组U-RI随孕周增加逐渐降低;与分娩组相比,孕7、8、9周时流产组的URI明显升高,差异有统计学意义(P=0.008,P=0.001,P=0.043)。结论:孕前NK细胞毒性增高,孕7~9周子宫动脉血流灌注量下降的患者再次自然流产风险增高,两者为独立危险因素。 | 颜妍 屠韡燕 王磊 王柳柳 鲍时华 Joanne Kwak-Kim | 2016 | 现代妇产科进展2016，25，3： | 13 |
| 8 | 自身抗体阳性复发性自然流产患者的子宫动脉血流阻力变化显示文摘目的:研究自身抗体阳性的复发性自然流产(RPL)患者的子宫动脉血流阻力(U-RI)指数的变化。方法:回顾分析189例RPL患者(≥3)的临床资料,比较孕前自身抗体阳性和阴性患者的U-RI指数。结果:抗磷脂抗体(APA)阳性患者的U-RI明显高于APA阴性组(P=0.018),APA-Ig G阳性组和APA-Ig A阳性组的U-RI明显高于APA阴性组(P=0.015,P=0.030),APA-Ig G、APA-Ig A阳性组的U-RI分别与APA-Ig G、APA-Ig A阴性组比较,差异有统计学意义(P=0.025,P=0.049),抗磷脂酸抗体(APAA)阳性组和抗磷脂酰肌醇抗体(APIA)阳性组的U-RI明显高于APA阴性组(P=0.045,P=0.048)。抗核抗体(ANA)阳性组和阴性组的U-RI比较,差异无统计学意义(P=0.235)。ANA阳性不同滴度和不同荧光核型组的U-RI比较,差异无统计学意义(P=0.384,P=0.181);其他抗体:anti-thyroid antibody(ATA)、ds DNA、ss DNA、Histone及Scl70阳性组和阴性组的URI比较,差异均无统计学意义(P>0.05)。结论:APA阳性的RPL患者子宫动脉血流容易出现高阻,可能会引起子宫动脉血流灌注不足现象发生。 | 胡晶晶 朱盈 李国华 洪向丽 鲍时华 Joanne Kwak-Kim | 2015 | 现代妇产科进展2015，24，8： | 11 |
| 9 | 新型去甲斑蝥素衍生物的设计合成及体外抗肿瘤活性显示文摘目的:设计合成新型去甲斑蝥素衍生物,并研究其体外抗肿瘤活性。方法:以呋喃和马来酸酐为起始原料经多步反应合成去甲斑蝥素衍生物,化合物经1HNMR、ESI-MS和元素分析确证结构;用MTT法,首先对所有化合物进行抗乳腺癌细胞株4T1体外活性筛选,然后对活性较好的化合物7a和7c进一步作抗肺癌细胞株LLC和抗肝癌细胞株SK-HEP-1的活性检测,同时对这2种化合物进行对正常血管内皮细胞ABAE的损伤试验。结果:设计合成了18种新化合物。其中化合物7a和7c对肿瘤细胞株有一定的抑制作用,而对正常细胞的损伤程度较低。结论:化合物7a和7c对乳腺癌细胞株4T1、肺癌细胞株LLC和肝癌细胞株SK-HEP-1有一定的抑制作用,尤其是化合物7c对正常内皮细胞ABAE的损伤比对照药去甲斑蝥素小得多,有进一步研究的价值。 | 董环文 刘超美 李科 Lurong Zhang Joanne Kim | 2008 | 第二军医大学学报2008，29，12： | 9 |
| 10 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 11 | 外周血NK细胞动态监测与遗传性易栓症患者妊娠结局的相关性研究显示文摘目的:探讨反复妊娠失败合并遗传性易栓症患者外周血NK细胞百分数及其杀伤活性对妊娠结局的影响。方法:采用单中心、回顾性队列研究方法,纳入2009年1月至2013年12月期间于Chicago Medical School at Rosalind Franklin University of Medicine and Science就诊的178例反复妊娠失败合并遗传性易栓症患者,使用流式细胞技术测定孕前及孕期外周血NK细胞百分数及杀伤活性,分析比较其与患者妊娠结局的关系。结果:外周血NK细胞百分数与其杀伤活性呈正相关;妊娠结局为流产组的患者各孕周NK细胞百分数及杀伤活性均高于活产组,其中孕前及孕6周时差异存在统计学意义。在调整包括年龄、BMI、NK细胞杀伤活性在内的协变量后,多元回归方程提示:孕前外周血NK细胞百分数≥12%的患者发生流产风险是NK细胞百分数<12%的患者的4.75倍(OR 4.75,95%CI 1.57~14.32,P=0.01);而在孕6周时,外周血NK百分数≥12%的患者发生流产风险是NK细胞百分数<12%患者的6.77倍(OR 6.77,95%CI 1.06~43.11,P=0.04)。结论:外周血NK细胞百分数及其杀伤活性均与遗传性易栓症患者妊娠结局相关,孕前和孕6周时NK细胞百分数≥12%是不良妊娠结局的独立危险因素。 | 阮加里 朱丹 李阳阳 Kwak-Kim Joanne 鲍时华 | 2020 | 中国免疫学杂志2020，36，5： | 8 |
| 12 | Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer显示文摘Hepatocellular carcinoma(HCC) is now the second leading cause of cancer-related deaths globally and many patients have incurable disease. HCC predominantly occurs in the setting of liver cirrhosis and is a paradigm for inflammation-induced cancer. The causes of chronic liver disease promote the development of transformed or premalignant hepatocytes and predisposes to the development of HCC. For HCC to grow and progress it is now clear that it requires an immunosuppressive niche within the fibrogenic microenvironment of cirrhosis. The rationale for targeting this immunosuppression is supported by responses seen in recent trials with checkpoint inhibitors. With the impact of immunotherapy, HCC progression may be delayed and long term durable responses may be seen. This makes the management of the underlying liver cirrhosis in HCC even more crucial as studies demonstrate that measures of liver function are a major prognostic factor in HCC. In this review, we discuss the development of cancer in the setting of liver inflammation and fibrosis, reviewing the microenvironment that leads to this tumourigenic climate and the implications this has for patient management. | Joanne Marie O'Rourke Vandana Mridhu Sagar Tahir Shah Shishir Shetty | 2018 | World Journal of Gastroenterology2018，24，39： | 8 |
| 13 | Cardiac evaluation of liver transplant candidates显示文摘Physicians previously thought that heart disease was rare in patients with end stage liver disease. However, recent evidence shows that the prevalence of ischemic heart disease and cardiomyopathy is increased in transplant candidates compared to most other surgical candidates. Investigators estimate that up to 26% of all liver transplant candidates have at least one critical coronary artery stenosis and that at least half of these patients will die perioperatively of cardiac complications. Cardiomyopathy also occurs in greater frequency. While all patients with advanced cardiac disease have defects in cardiac performance, a larger than expected number of patients have classical findings of dilated, restrictive and hypertropic cardiomyopathy. This may explain why up to 56% of patients suffer from hypoxemia due to pulmonary edema following transplant surgery. There is considerable controversy on how to screen transplant candidates for the presence of heart disease. Questions focus upon, which patients should be screened and what tests should be used. This review examines screening strategies for transplant candidates and details the prognostic value of common tests used to identify ischemic heart disease. We also review the physiological consequences of cardiomyopathy in transplant candidates and explore the specific syndrome of 'cirrhotic cardiomyopathy'. | Mercedes Susan Mandell JoAnn Lindenfeld Mei-Yung Tsou Michael Zimmerman | 2008 | World Journal of Gastroenterology2008，14，22： | 8 |
| 14 | Seasonal Rainfall Forecasts for the Yangtze River Basin of China in Summer 2019 from an Improved Climate Service显示文摘Rainfall forecasts for the summer monsoon season in the Yangtze River basin(YRB) allow decision-makers to plan for possible flooding, which can affect the lives and livelihoods of millions of people. A trial climate service was developed in 2016, producing a prototype seasonal forecast product for use by stakeholders in the region, based on rainfall forecasts directly from a dynamical model. Here, we describe an improved service based on a simple statistical downscaling approach. Through using dynamical forecast of an East Asian summer monsoon(EASM) index, seasonal mean rainfall for the upper and middle/lower reaches of YRB can be forecast separately by use of the statistical downscaling, with significant skills for lead times of up to at least three months. The skill in different sub-basin regions of YRB varies with the target season. The rainfall forecast skill in the middle/lower reaches of YRB is significant in May–June–July(MJJ), and the forecast skill for rainfall in the upper reaches of YRB is significant in June–July–August(JJA). The mean rainfall for the basin as a whole can be skillfully forecast in both MJJ and JJA. The forecasts issued in 2019 gave good guidance for the enhanced rainfall in the MJJ period and the near-average conditions in JJA. Initial feedback from users in the basin suggests that the improved forecasts better meet their needs and will enable more robust decision-making. | Philip E.BETT Nicola MARTIN Adam A.SCAIFE Nick DUNSTONE Gill M.MARTIN Nicola GOLDING Joanne CAMP Peiqun ZHANG Chris D.HEWITT Leon HERMANSON Chaofan LI Hong-Li REN Ying LIU Min LIU | 2020 | Journal of Meteorological Research2020，34，5： | 7 |
| 15 | 中国大陆日本血吸虫微卫星DNA的初步研究显示文摘目的 研究中国大陆日本血吸虫 (Schistosoma japonicum)微卫星 DNA基因变异。方法 日本血吸虫种群取自中国大陆 7个流行省现场 :浙江省 (嘉善 ) ,安徽省 (贵池 ) ,江西省 (永修 ) ,湖北省 (武汉 ) ,湖南省 (岳阳 ) ,四川省 (茅山 ,天全 ) ,云南省 (大理 ) ,以及菲律宾 Sorsogon省。对每一种群2 0个样本的 DNA,用 6个日本血吸虫微卫星 :M5 A,J5 N,MF1,RRPS,2 AAA和 MPA分析。结果 中国大陆日本血吸虫不同的种群之间和种群内存在高水平的多态性 ,进一步证实中国株和菲律宾株分属不同虫株 ,在中国大陆不同种群间也存在明显遗传变异。结论 证明了用微卫星对日本血吸虫进行种群基因学研究的可行性 。 | 钱宝珍 Jaya Shrivastava Joanne P.Webster 贺晨 | 2004 | 中国血吸虫病防治杂志2004，16，4： | 6 |
| 16 | Murine lung eosinophil activation and chemokine production in allergic airway inflammation显示文摘Eosinophils play important roles in asthma and lung infections.Murine models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these diseases.However,little is known about tissue eosinophils in homeostasis.In addition,little data on eosinophil chemokine production during allergic airway inflammation are available.In this study,the properties and functions of homeostatic and activated eosinophils were compared.Eosinophils from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell proliferation.However,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine proteins.Eosinophil intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal degranulation.Lung eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c expression.They were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed lungs.Eosinophil production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation. | C Edward Rose Jr Joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung | 2010 | Cellular & Molecular Immunology2010，7，5： | 6 |
| 17 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet . 2005 (9472)2005，，9472： | 6 |
| 18 | The importance of depression and alcohol use in coronary artery bypass graft surgery patients:risk factors for delirium and poorer quality of life显示文摘ObjectiveTo 调查消沉,焦虑和压力是否增加风险因为谵妄和在冠的动脉以后的生活(QOL ) 的差的质量绕过(CABG ) 180 个 CABG 病人的 surgery.MethodsA 总数(63.5 ± 的吝啬的年龄;10.1 年, 82.2% 男性) 完成了基线和手术后的自我报告问询表估计悲痛和 QOL。事件谵妄与结构化的临床的会见手术后地被诊断,病人们在在 63 个人(35% 样品) 开发的 consciousness.ResultsDelirium 为混乱和骚乱 post-operatively 每天被监视。在为 covariates 的调整以后,谵妄显著地与消沉被联系[机会比率(或) :1.08;95% 信心间隔(CI ) :1.03-1.13, P = 0.003 ] ,焦虑(或:1.07;95% CI:1.02-1.13, P = 0.01 ) 并且应力(或:1.05;95% CI:1.00-1.09, P = 0.03 ) 。外科手术前的消沉分数与更差的 QOL 包括被联系身体疼痛(β=− 0.39, P = 0.013 ) ,活力(β=− 0.32, P = 0.020 ) ,社会工作(β=− 0.51, P ≤0.001 ) ,感情的角色功能(β=− 0.44, P = 0.003 ) 并且一般健康(β=− 0.33, P = 0.038 ) 。在 covariates 之中,白酒使用的有害层次一致地与更差的 QOL.ConclusionsDepression 被联系,而消沉,焦虑和压力与谵妄风险被联系,白酒使用的有害层次一致地与更差的 QOL 被联系。这些调查结果点将推进在经历冠的 revascularization 的冠的心疾病人口检验消沉和白酒使用的有害层次的研究。 | Joanne M Humphreys Linley A Denson Robert A Baker Phillip J Tully | 2016 | Journal of Geriatric Cardiology2016，13，1： | 5 |
| 19 | Hereditary diffuse gastric cancer: What the clinician should know显示文摘Hereditary diffuse gastric cancer(HDGC) is an inherited autosomal dominant syndrome with a penetrance of up to 80% affecting diverse geographic populations. While it has been shown to be caused mainly by germline alterations in the E-cadherin gene(CDH1), problematically, the genetic diagnosis remains unknown in up to 60% of patients. Given the important knowledge gaps regarding the syndrome, asymptomatic carriers of CDH1 mutations are advised for a prophylactic total gastrectomy. Intensive annual endoscopic surveillance is the alternative for carriers who decline gastrectomy. As HDGCs have a prolonged indolent phase, this provides a window of opportunity for surveillance and treatment. Recent findings of other gene defects in CTNNA1 and MAP3K6, as well as further characterization of CDH1 mutations and their pathogenicity will change the way HDGC patients are counselled for screening, surveillance and treatment. This review will bring the reader up to date with these changes and discuss future directions for research; namely more accurate risk stratification and surveillance methods to improve clinical care of HDGC patients. | Ryan Ying Cong Tan Joanne Ngeow | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 5 |
| 20 | 1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience显示文摘 | Jordan M. Winter John L. Cameron Kurtis A. Campbell Meghan A. Arnold David C. Chang JoAnn Coleman Mary B. Hodgin Patricia K. Sauter Ralph H. Hruban Taylor S. Riall Richard D. Schulick Michael A. Choti Keith D. Lillemoe Charles J. Yeo | 2006 | Journal of Gastrointestinal Surgery2006，，9： | 5 |
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