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| 1 | Medical treatment of unresectable hepatocellular carcinoma: Going beyond sorafenib显示文摘Even though Sorafenib has radically changed the natural history of those hepatocellular carcinoma patients who are not amenable for curative treatments, further therapeutic improvements are badly needed. As it was for Sorafenib, our increasingly refined understanding of the complex mechanisms underlying HCC carcinogenesis are the starting point for the future development of such treatments. Presently, a number of molecularly targeted agents are in different stages of development for this once orphan cancer. Indeed, several pathways are presently being explored to identify potentially active drugs, including epidermal growth factor receptor, vascular endothelial growth factor/vascular endothelial growth factor receptors, mammalian target of rapamycin, phosphatidyl-inositol-3-kinase/Akt, insulin growth factor, Aurora kinase, Wnt/β-catenin, retinoic acid receptor and hepatocyte growth factor/C-Met. This review is aimed at addressing the results obtained so far with these newer drugs, also considering the challenges we shall face in the near future, including the issue of response evaluation and identification of predictive/ prognostic biomarkers. | Camillo Porta Chiara Paglino | 2010 | World Journal of Hepatology2010，2，3： | 3 |
| 2 | Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis显示文摘 | Seth Rakoff-Nahoum Justin Paglino Fatima Eslami-Varzaneh Stephen Edberg Ruslan Medzhitov | 2004 | Cell2004，，2： | 2 |
| 3 | Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis显示文摘 | Seth Rakoff-Nahoum Justin Paglino Fatima Eslami-Varzaneh Stephen Edberg Ruslan Medzhitov | 2004 | Cell2004，，2： | 2 |
| 4 | Recognition of commensal microflora by toll - like receptors is required for intestinal ho- meostasis 显示文摘 | Rakoff - Nahoum Justin Paglino S Fatima Eslami - Varzaneh | 2004 | Ceil2004，365，7： | 1 |
| 5 | Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis显示文摘 | Rakoff-nahoum S Paglino J Eslami-Varzaneh F | 2004 | Cell2004，118，2： | 1 |
| 6 | Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis显示文摘 | Raroff-Nahoum S Paglino J Eslami-Varzaneh F | | 0，，02： | 1 |
| 7 | Recogni- tion of commensal microflora by toll-like receptors is required for in- testinal homeostasis显示文摘 | Raroff-Nahoum S Paglino J Eslami Varzaneh F | 2004 | Cell2004，118，2： | 1 |
| 8 | Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis 显示文摘 | Rakoff-Nahoum S Paglino J Eslami-Varzaneh F | 2004 | Cell2004，118，2： | 1 |
| 9 | Recog- nition of commensal microflora by toll like recertors is required for intestinal homeostasis显示文摘 | Rakoff-Nahoum S Paglino J Eslami-Varzaneh F | 2004 | Cell2004，118，2： | 1 |
| 10 | Ageing and COPD affectdifferent domains of nutritional status:the ECCE study显示文摘 | Battaglia S Spatafora M Paglino G | 2011 | Eur Respir J2011，37，6： | 1 |
| 11 | Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis 显示文摘 | Rakoff Nahoum S Paglino J Eslami Varzaneh F | 2004 | Cell2004，118，2： | 1 |
| 12 | Retion of commensal microfora toll-like receptors is requir for intestial homeostasis显示文摘 | Rakoff-Nahoum S Paglino J Esami-Varzaneh F | 2004 | Cell2004，118，2： | 1 |
| 13 | Results of operative fixation of unstable ankle fracture in geriatric patients显示文摘 | Paglino A J Mixhwlaon JD | 2001 | Foot - Ankle - Int2001，22，5： | 1 |
| 14 | Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis显示文摘 | Rakoff-Nahoum S Paglino J Eslami-Varzaneh F | 2004 | Cell2004，118，2： | 1 |
| 15 | Sunitinib re-challenge in advanced renal-cell carcinoma显示文摘 | Porta C Paglino C Grünwald V | 2014 | Br J Cancer2014，111，6： | 1 |
| 16 | Ageing and COPD affect different domains of nutritional status:the ECCE study显示文摘 | Battaglia S Spatafora M Paglino G | 2011 | Eur Respir J2011，37，6： | 1 |
| 17 | Tracheal stent to repair tracheal laceration after a double-lumen intuba- tion显示文摘 | Marchese R Mercadante S Paglino G | 2012 | Ann Thorac Surg2012，94，3： | 1 |
| 18 | Targeting PI3K/Akt/mTOR signaling in cancer显示文摘 | Porta C Paglino C Mosca A | 2014 | Front Oncol2014，4，： | 1 |
| 19 | Targeting PI3K/Akt/mTOR signaling in cancer显示文摘 | Porta C Paglino C Mosca A | 2014 | Front Oncol2014，4，： | 1 |
| 20 | Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis 显示文摘 | Raroff Nahoum S Paglino J Eslami-Varzaneh F | 2004 | Cell2004，118，： | 1 |
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