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| 1 | Perioperative glucose management and outcomes in liver transplant recipients: A qualitative systematic review显示文摘AIM To investigate the relationship between post-liver transplantation(LT) glycemic control and LT outcomes. METHODS A qualitative systematic review on relevant prospective interventions designed to control glucose levels including insulin protocols. Studies investigating an association between glycemic control and post-LT outcomes such as mortality, graft rejection, and infection rate were reviewed. Pub Med, EMBASE, and other databases were searched through October 2016. RESULTS Three thousands, six hundreds and ninety-two patients from 14 studies were included. Higher mortality rate was seen when blood glucose(BG) ≥ 150 mg/dL(P = 0.05). BG ≥ 150 mg/dL also led to higher rates of infection. Higher rates of graft rejection were seen at BG > 200 mg/dL(P < 0.001). Mean BG ≥ 200 mg/dL was associated with more infections(P = 0.002).Nurse-initiated protocols and early screening strategies have shown a reduction in negative post-LT outcomes.CONCLUSION Hyperglycemia in the perioperative period is associated with poor post-LT outcomes. Only a few prospective studies have designed interventions aimed at managing post-LT hyperglycemia, post-transplant diabetes mellitus(PTDM) and their impact on post-LT outcomes. | Prani Paka Sarah R Lieber Ruth-Ann Lee Chirag S Desai Robert E Dupuis Alfred Sidney Barritt | 2018 | World Journal of Transplantation2018，8，3： | 2 |
| 2 | Measurement of residual stresses in polymeric parts by indentation method 显示文摘 | PAKA S Y KIMB S Y KIMC S H | 2013 | Polymer Testing2013，32，5： | 1 |
| 3 | A protective role for kidney apolipoprotein E :Regulation of mesangial cell proliferation and matrixs expansion显示文摘 | Paka L Kako Y | 2001 | J Biol Chem2001，276，49： | 1 |
| 4 | Distinct effects of glucose and glucosamine on vascular endothelial and smooth muscle cells: Evidence for a protective role for gluccosamine in atherosclerosis显示文摘 | Duan W Paka L | 2005 | Cardiovasc Diabetes2005，4，： | 1 |
| 5 | Cyclophosphamide with low or high dose prednisolone for systemic sclerosis lung disease 显示文摘 | Pakas I Ioannidis JA Malagari K | 2002 | J Rheumatol2002，29，： | 1 |
| 6 | Distinct effects of glucose and glucosamine on vascular endothelial and smooth muscle cells:evidence for a protective role for glucosamine in atherosclerosis显示文摘 | Duma W Paka L Pillarisetti S | 2005 | Cardiovascular Diabetology2005，4，： | 1 |
| 7 | Curcumin protects neuronal- like cells against acrolein by restoring Akt and redox signaling pathways 显示文摘 | Daggui S Belkacemi A Paka GD | 2013 | Mol Nutr Food Res2013，57，9： | 1 |
| 8 | Predictive factors and treat-ment of recurrence of endometriosis显示文摘 | Paka C Miller J Nezhat C | | 0，，02： | 1 |
| 9 | Randomized Comparison of Levonorgestrel Releasing and Copper Releasing Intrauterine Systems Im-mediately After Abortion,With 5 Years Follow Up显示文摘 | Paka rinen P Toivonen J Luukkainen T | 2003 | Contraception2003，68，1： | 1 |
| 10 | Cyclophosphamide with low or high dose prednisolane for systemic sclerosis lung dis- ease 显示文摘 | Pakas I Ioannidis J P Malagari K | 2002 | J Rheumatol2002，29，： | 1 |
| 11 | Subendothelial retention of lipoprotein: evidence that reduced heparan sulfate promotes lipoprotein binding to Subendothelial matrix显示文摘 | Pillarisetti S Paka L Obunike JC | | 0，，： | 1 |
| 12 | Cyclophospha- mide with low or high dose prednisolone for systemic sclerosis lung disease显示文摘 | PAKAS I IOANNIDIS J P MALAGARI K | 2002 | J Rheumatol2002，29，2： | 1 |
| 13 | A small molecule fibrokinase inhibitor in a model of fibropolycystic hepatorenal disease显示文摘AIM To evaluate the novel platelet-derived growth factor receptor and vascular endothelial growth factor receptor dual kinase inhibitor ANG3070 in a polycystic kidney disease-congenital hepatic fibrosis model.METHODS At 6 wk of age, PCK rats were randomized to vehicle or ANG3070 for 4 wk. At 10 wk, 24 h urine and left kidneys were collected and rats were continued on treatment for 4 wk. At 14 wk, 24 h urine was collected, rats were sacrificed, and liver and right kidneys were collected for histological evaluation. For Western blot studies, PCK rats were treated with vehicle or ANG3070 for 7 d and sacrificed approximately 30 min after the last treatments.RESULTS Compared to the wild-type cohort, the PCK kidney(Vehicle cohort) exhibited a marked increase in kidney and liver mass, hepato-renal cystic volume, hepato-renal fibrosis and hepato-renal injury biomarkers. Intervention with ANG3070 in PCK rats decreased kidney weight, reduced renal cystic volume and reduced total kidney hydroxyproline, indicating significantly reduced rental interstitial fibrosis compared to the PCK-Vehicle cohort. ANG3070 treatment also mitigated several markers of kidney injury, including urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, cystatin C and interleukin-18 levels. In addition, this treatment attenuated key indices of renal dysfunction, including proteinuria, albuminuria and serum blood urea nitrogen and creatinine, and significantly improved renal function compared to the PCK-Vehicle cohort. ANG3070 treatment also significantly decreased liver enlargement, hepatic lesions, and liver fibrosis, and mitigated liver dysfunction compared to the PCK-Vehicle cohort.CONCLUSION These results suggest that ANG3070 has the potential to slow disease, and may serve as a bridge toward hepato-renal transplantation in patients with fibropolycystic disease. | Prani Paka Brian Huang Bin Duan Jing-Song Li Ping Zhou Latha Paka Michael A Yamin Scott L Friedman Itzhak D Goldberg Prakash Narayan | 2018 | World Journal of Nephrology2018，7，5： | 1 |
| 14 | Systemic scleroderma in Greece: low mortality and strong linkage with HLA-- DRB1 * 1104 allele显示文摘 | Vlachoyiannopoulos PG Dafni UG Pakas I | 2000 | Ann Rheum Dis2000，59，5： | 1 |
| 15 | Predictive factors and treatment of recurrence of endometriosis显示文摘 | Paka C Miller J Nezhat C | 2013 | Minerva ginecologica2013，65，2： | 1 |
| 16 | Bilateral thoracic endometriosis affecting the lung and diaphragm显示文摘 | Nezhat C King LP Paka C | 2012 | JSLS2012，16，1： | 1 |
| 17 | Distinct effects of glucose and glucosarriine on vascular endothelial and smooth muscle cells: Evidence for a protectiv role for glucosamine in atherosclerosis 显示文摘 | Duan W Paka L | 2005 | Cardiovasc Diabetes2005，4，： | 1 |
| 18 | Bilateral thoracic endo- metriosis affecting the lung and diaphragm显示文摘 | Nezhat C King LP Paka C | 2012 | JSLS2012，16，1： | 1 |
| 19 | Predictive factors and treat- ment of recurrence of endometriosis显示文摘 | L Paka C Miller J Nezhat C | 2013 | Minerva Ginecol2013，65，2： | 1 |
| 20 | Systemic scleroderma in Greece:low mortality and strong linkage with HLA-DRB1 *1104 allele显示文摘 | Vlachoyiannopoulos PG Dafni UG Pakas I | 2000 | Ann Rheum Dis2000，59，5： | 1 |
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