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| 1 | Modified porous tantalum rod technique for the treatment of femoral head osteonecrosis显示文摘AIM: To study a modified porous tantalum technique for the treatment of osteonecrosis of the femoral head.METHODS: The porous tantalum rod was combined with endoscopy,curettage,autologous bone grafting and use of bone marrow aspirates from iliac crest aspiration in 49 patients(58 hips) with a mean age of 38 years.The majority of the patients had idiopathic osteonecrosis,followed by corticosteroid-induced osteonecrosis.Thirtyeight hips were of Steinberg stage Ⅱ disease and 20 hips were of stage Ⅲ disease.Patients were followed for 5 years and were evaluated clinically with the Merle D'Aubigne and Postel score and radiologically.The primary outcome of the study was survival based on the conversion to total hip arthroplasty(THA).Secondary outcomes included deterioration of the osteonecrosis to a higher disease stage at 5 years compared to the preoperative period and identification of factors that were associated with survival.The Kaplan-Meier survival analysis was performed to evaluate the survivorship ofthe prosthesis,and the Fisher exact test was performed to test associations between various parameters with survival.RESULTS: No patient developed any serious intraoperative or postoperative complication including implant loosening or migration and donor site morbidity.During the 5-year follow up,1 patient died,7 patients had disease progression and 4 hips were converted to THA.The 5-year survival based on conversion to THA was 93.1% and the respective rate based on disease progression was 87.9%.Stage Ⅱ disease was associated with statistically significant better survival rates compared to stage Ⅲ disease(P = 0.04).The comparison between idiopathic and non-idiopathic osteonecrosis and between steroid-induced and non-steroid-induced osteonecrosis did not showed any statistically significant difference in survival rates.The clinical evaluation revealed statistically significantly improved Merle d'Aubigne scores at 12 mo postoperatively compared to the preoperative period(P < 0.001).The mean preoperative Merle d'Aubigne score was 13.0(SD: 1.8).The respective score at 12 mo improved to 17.0(SD: 2.0).The 12-mo mean score was retained at 5 years.CONCLUSION: The modified porous tantalum rod technique presented here showed encouraging outcomes.The survival rates based on conversion to THA are the lowest reported in the published literature. | Emilios E Pakos Panayiotis Megas Nikolaos K Paschos Spyridon A Syggelos Antonios Kouzelis Georgios Georgiadis Theodoros A Xenakis | 2015 | World Journal of Orthopedics2015，6，10： | 20 |
| 2 | Use of ^99Tc^m- sulesomab for the diagnosis of prosthesis infection after total joint arthroplasty 显示文摘 | Pakos E E Fotopoulos A D Stafilas K S | 2007 | J Int Med Res2007，35，4： | 1 |
| 3 | Multi-focal gliosarco- ma: a case report and review of the literature显示文摘 | Pakos E E Goussia A C Zina V P | 2005 | J Neurooncol2005，74，3： | 1 |
| 4 | Multi-focal gliosarco- ma: a case report and review of the literature显示文摘 | Pakos E E Goussia A C Zina V P | 2005 | J Neurooncol2005，74，3： | 1 |
| 5 | Prevention of heterotopic ossification in high-risk patients with total hip arthroplasty: the experience of a combined therapeutic protocol 显示文摘 | Pakos EE Pitouli E J Tsekeris PG | 2006 | Int Orthop2006，30，： | 1 |
| 6 | Combined radiotherapy and indomethacin for the prophylaxis of heterotopic ossification after total hip arthroplasty显示文摘 | Pakos E E Stafila K S Tsekeris P G | 2009 | Strahlenther Onkol2009，185，8： | 1 |
| 7 | Accuracy of pediele screw placement : a systematic review of prospective in vivo studies comparing free hand, fluoroscopy guidance and navigation techniques 显示文摘 | GELALIS I D PASCHOS N K PAKOS E E | 2012 | Eur Spine J2012，21，2： | 1 |
| 8 | The role of radiation dose in a combined therapeutic protocol for the prevention of heterotopic ossification after total hip replacement显示文摘 | Pakos E E Tsekeris P G Paschos N K | 2010 | J Buon2010，15，1： | 1 |
| 9 | Pre-ention of hetero- topic ossification in high - risk patients with total hip arthroplas- ty: the experience of a combined therapeutic protocol 显示文摘 | Pakos EE Pitouli E J Tsekeris PG | 2006 | Int Or- thop2006，30，2： | 1 |
| 10 | Adjuvant Chemo-radiotherapy in Patients with Gastric Cancer显示文摘 | Capizzello A Tsekeris P G Pakos E E | 2006 | India J Cancer2006，43，4： | 1 |
| 11 | Patellar resurfacing in total knee arthroplasty: A meta-analysis 显示文摘 | PAKOS E E NTZANI E E TRIKALINOS T A | 2005 | Journal of Bone and Joint Surgery (American)2005，87，7： | 1 |
| 12 | Prognostic factors and outcomes for osteosarcoma:An international collaboration显示文摘 | PAKOS E E NEARCHOU A D GRIMER R J | | 0，，： | 1 |
| 13 | Accuracy of pedicle screw placement : a systematic review of prospective in vivo studies comparing free hand, fluoroscopy guidance and navigation techniques 显示文摘 | GELALIS I D PASCHOS N K PAKOS E E | 2012 | Eur Spine J2012，21，2： | 1 |
| 14 | Effect of inter- laminar epidural steroid injection in acute and subaeute pain due to lumbar disk herniation: a randomized comparison of 2 different protocols显示文摘 | Gelalis ID Arnaoutoglou E Pakos EE | 2009 | Open Orthop J2009，3，： | 1 |
| 15 | Multi-focal gliosarcoma: a case report and review of the literature显示文摘 | Pakos E E Goussia A C Zina V P | 2005 | J Neurooncol2005，74，3： | 1 |
| 16 | Clinicopathologic study of E-cadherin/beta-catenin complex, and topoisomerase-II in a series of 71 liposarcoma cases显示文摘 | Gogou P Pakos E Batistatou A | 2012 | World J Surg Oncol2012，10，： | 1 |
| 17 | Effect of interlaminar epidural steroid injection in acute and subacute pain due to lumbar disk herniation: a randomized comparison of 2 different protocols显示文摘 | Gelalis ID Amaoutoglou E Pakos EE | 2009 | Open Orthop J2009，24，： | 1 |
| 18 | Patellar instability after total knee arthroplasty 显示文摘 | Motsis E K Paschos N Pakos E E | 2009 | J Orthop Surg ( Hong Kong)2009，17，3： | 1 |
| 19 | Topical use of tranexamic acid:Are there concerns for cytotoxicity?显示文摘Tranexamic acid(TXA)has revolutionized modern blood management in orthopaedic surgery,especially in total joint arthroplasty,by significantly reducing blood loss and transfusion rates.It is an antifibrinolytic agent and a synthetic derivative of the amino acid lysine,which can inhibit the activation of plasminogen and the fibrin breakdown process.The administration of TXA can be intravenous(IV),topical,and oral.In patients where the IV administration is contraindicated,topical use is preferred.Topical administration of the drug theoretically increases concentration at the operative site with reduced systemic exposure,reduces cost,and gives the surgeon the control of the administration.According to recent studies,topical administration of TXA is not inferior compared to IV administration,in terms of safety and efficacy.However,there are concerns regarding the possible toxicity in the cartilage tissue with the topical use of TXA mainly in hemiarthroplasty operations of the hip,unilateral knee arthroplasties,total knee arthroplasties where the patella is not resurfaced,and other intraarticular procedures,like anterior cruciate ligament reconstruction.The purpose of the present review is to present all the recent updates on the use of TXA focusing on the toxicity on chondrocytes and the articular cartilage that may or may not be provoked by the topical use of TXA. | Ioannis Gkiatas Aristeidis-Panagiotis Kontokostopoulos Spyridon E Tsirigkakis Ioannis Kostas-Agnantis Ioannis Gelalis Anastasios Korompilias Emilios Pakos | 2022 | World Journal of Orthopedics2022，13，6： | 0 |
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