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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | Activation-dependent expression of the blood group-related Lewis Y antigen on peripheral blood granulocytes显示文摘 | Dettke M Palfi G Loibner H | 2000 | J Leukoc Biol2000，68，4： | 1 |
| 3 | Dual role of the anti-inflammatory sesquiterpene lactone : reg- ulation of life and death by parthenolide 显示文摘 | Li-Weber M Palfi K Giaisi M | 2005 | Cell Death Differ2005，12，4： | 1 |
| 4 | UPb and 'Ar/agAr dating of the Miocene fossil track site at Ipolytarnoc (Hunga ry) and its imp|ieations显示文摘 | Palfy J Mundil R Renne P R | 2007 | Earth and Planetary Science Let- ters2007，258，： | 1 |
| 5 | Cardioprotection by resveratrol:a human clinical trial in patients with stablecoronary artery disease 显示文摘 | Magyar K Halmosi R Palfi A | 2012 | Clin Hemorheol Microcirc2012，50，3： | 1 |
| 6 | Placental transport of maternal immunoglobulin G显示文摘 | Palfi M Selbing A | 1998 | Am J Reprod Immunol1998，39，1： | 1 |
| 7 | Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman promates: diminished compensatory mechanisms as a prelude to parkinsonism显示文摘 | Collier T J Lipton J Daley B F Palfi S Chu Y Sortwell C | 2007 | Neurobiol Dis2007，26，： | 1 |
| 8 | Studies on the decline of bovine virus diarrhea virus (BVDV) maternal antibodies and detectability of BVDV in persistently infected calves 显示文摘 | Palfi V Houe H Philipsen J | 1993 | Acta Vet Scand1993，，34： | 1 |
| 9 | Prevention of recurrent spontaneous abortion by intravenous immunoglobulin: a double-blind placebo-controlled study显示文摘 | Jablonowska B Selbing A Palfi M | 1999 | Hum Reprod1999，14，3： | 1 |
| 10 | Isolation of equine herpesvirus type 2from foals,showing respiratory symptoms显示文摘 | Palfi V Belak S Molnar T | 1978 | Zentralbl Veterinarmed B1978，25，2： | 1 |
| 11 | Development of strategies for conditional RNA interference显示文摘 | Allen D Kenna PF Palfi A | 2007 | J Gene Med2007，9，4： | 1 |
| 12 | RNAi-based suppression and replacement of rds-peripherin in retinal organotypic culture 显示文摘 | Palfi A Ader M Kiang AS | 2006 | Hum Mutat2006，27，3： | 1 |
| 13 | Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy显示文摘 | Chadderton N Millington-Ward S Palfi A O' Reilly M Tuohy G Humphries MM | 2009 | Mol Ther2009，17，4： | 1 |
| 14 | Bovine viral diarrhoea virus genotype 1 can be separated into at least eleven genetic groups显示文摘 | ?. Vil?ek D. J. Paton B. Durkovic L. Strojny G. Ibata A. Moussa A. Loitsch W. Rossmanith S. Vega M. T. Scicluna V. Palfi | 2001 | Archives of Virology2001，，1： | 1 |
| 15 | SMN-assisted assembly of snRNP-specific Sm cores in trypanosomes显示文摘 | Palfi Z Jae N Preusser C Kaminska K H | 2009 | Genes Dev2009，23，14： | 1 |
| 16 | A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa 显示文摘 | O'Reilly M Millington-Ward S Palfi A | 2008 | Vision Res2008，48，3： | 1 |
| 17 | Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa 显示文摘 | Loscher C J Hokamp K Kenna PF Ivens AC Humphries P Palfi A | 2007 | Genome Biol2007，8，11： | 1 |
| 18 | Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease 显示文摘 | Magyar K Halmosi R Palfi A | 2012 | Clin Hemorheol Microcire2012，50，3： | 1 |
| 19 | A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa 显示文摘 | O'Reilly M Millington-Ward S Palfi A | 2008 | Vision Res2008，48，3： | 1 |
| 20 | Triassic-Jurassic boundary events: problems, progress, possibilities 显示文摘 | Hesselbo S P McRoberts C A Palfy J | 2007 | Palaeogeogr Palaeoclimatol Palaeoecol2007，244，： | 1 |
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