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| 1 | Laparoscopic versus open appendectomy: Which way to go?显示文摘AIM: To compare the outcome of laparoscopic versus open appendectomy. METHODS: Prospectively collected data from 293 consecutive patients with acute appendicitis were studied. These comprised of 165 patients who underwent conventional appendectomy and 128 patients treated laparoscopically. The two groups were compared with respect to operative time, length of hospital stay, postoperative pain, complication rate and cost. RESULTS: There were no statistical differences regarding patient characteristics between the two groups. Conversion to laparotomy was necessary in 2 patients (1.5%). Laparoscopic appendectomy was associated with a shorter hospital stay (2.2 d vs 3.1 d, P = 0.04), and lower incidence of wound infection (5.3% vs 12.8%, P = 0.03). However, in patients with complicated disease, intra-abdominal abscess formation was more common after laparoscopic appendectomy (5.3% vs 2.1%, P = 0.002). The operative time and analgesia requirements were similar in the two groups. The cost of treatment was higher by 370 € in the laparoscopic group. CONCLUSION: Laparoscopic appendectomy is as safe and effi cient as open appendectomy, provided surgical experience and equipment are available. | Ioannis Kehagias Stavros Nikolaos Karamanakos Spyros Panagiotopoulos Konstantinos Panagopoulos Fotis Kalfarentzos | 2008 | World Journal of Gastroenterology2008，14，31： | 25 |
| 2 | Histological healing favors lower risk of colon carcinoma in extensive ulcerative colitis显示文摘AIM:To search for the answer in extensive ulcerative colitis as to whether histological inflammation persisting despite endoscopic mucosal healing serves to increase the risk of colon cancer(CC)or high grade dysplasia(HGD).METHODS:This is a single center(Lenox Hill Hospital)retrospective cohort and descriptive study of extensive ulcerative colitis(UC)for 20 years or more with a minimum of 3 surveillance colonoscopies and biopsies performed after the first 10 years of UC diagnosis.Data analyzed included:duration of UC,date of diagnosis of(CC)or(HGD),number of surveillance colonoscopies,and biopsies showing histological inflammation and its severity in each of 6 segments when endoscopic appearance is normal.Two subgroups of patients were compared:group 1 patients who developed CC/HGD and group 2 patients who did not develop CC/HGD.RESULTS:Of 115 patients with longstanding UC reviewed,68 patients met the inclusion criteria.Twenty patients were in group 1 and 48 in group 2.We identified the number of times for each patient when the endoscopic appearance was normal but biopsies nevertheless showed inflammation.Overall,histological disease activity in the absence of gross/endoscopic disease was found in 31.2%(95%CI:28%-35%)of colonoscopies performed on the entire cohort of 68 patients.Histological disease activity when the colonoscopy showed an absence of gross disease activity was more common in group 1 than group 2 patients,88%(95%CI:72%-97%)vs 59%(95%CI:53%-64%).Only 3/20(15%)of patients in group 1 ever had a colonoscopy completely without demonstrated disease activity(i.e.,no endoscopic or histological activity)as compared to 37/48(77%)of patients in group 2,and only 3.3%(95%CI:0.09%-8.3%)of colonoscopies in group 1 had no histological inflammation compared to23%(95%CI:20%-27%)in group 2.CONCLUSION:Progression to HGD or CC in extensive ulcerative colitis of long standing was more frequently encountered among those patients who demonstrate persistent histological inflammation in the absence of gross mucosal disease.Our findings support including the elimination of histological inflammation in the definition of mucosal healing,and support this endpoint as an appropriate goal of therapy because of its risk of increasing dysplasia and colon cancer. | Burton I Korelitz Keith Sultan Megha Kothari Leo Arapos Judy Schneider Georgia Panagopoulos | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 3 | Choice of laxatives and colonoscopic preparation in pregnant patients from the viewpoint of obstetricians and gastroenterologists显示文摘AIM: To elucidate the preferences of gastroenterologists at our institution and compare them to those of obstetricians when making decisions in the pregnant patient, including which type of bowel preparations to use for ? exible sigmoidoscopy or colonoscopy, as well as which laxatives can be used safely. METHODS: Surveys were mailed to all attending gastroenterologists (n = 53) and obstetricians (n = 99) at our institution. Each survey consisted of the 14 most common laxative or motility agents used in pregnancy and inquired about the physician’s prescribing habits in the past as well as their willingness to prescribe each medication in the future. The survey also listed four common bowel preparations used prior to colonoscopy and sigmoidoscopy and asked the physician to rank the order of the preferred agent in each case. RESULTS: With regard to common laxatives, both gastroenterologists and obstetricians favor the use of Metamucil, Colace, and Citrucel. Both groups appear to refrain from using Fleets Phosphosoda and Castor oil. Of note, obstetricians are less inclined to use PEG solution and Miralax, which is not the case with gastroenterologists. In terms of comparing bowel preparations for colonoscopy, 50% of gastroenterologists prefer to use PEG solution and 50% avoid the use of Fleets Phosphosoda. Obstetricians seem to prefer Fleets Phosphosoda (20%) and tend to avoid the use of PEG solution (26%). With regard to bowel preparation for sigmoidoscopy, both groups prefer Fleets enema the most (51%), while magnesium citrate is used least often (38%). CONCLUSION: It is clear that preferences in the use ofbowel cleansing preparations between the two groups exist, but there have not been many case controlled human studies in the pregnant patient that give clear cut indications for using one versus another drug. In light of the challenge of performing controlled trials in pregnant women, more extensive surveys should be undertaken to gather a larger amount of data on physicians’ experiences and individual preferences. | Jeevan Vinod Jennifer Bonheur Burton I Korelitz Georgia Panagopoulos | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 4 | Abnormalities of uterine cervix in women with inflammatory bowel disease显示文摘AIM: To evaluate the prevalence of abnormalities of the uterine cervix in women with inflammatory bowel disease (IBD) when compared to healthy controls. METHODS: One hundred and sixteen patients with IBD [64 with Crohn’s disease (CD) and 52 with ulcerative colitis (UC)] were matched to 116 healthy controls by age (+/- 2 years) at the time of most recent papanicolaou (Pap) smear. Data collected consisted of age, race, marital status, number of pregnancies, abortions/miscarriages, duration and severity of IBD, Pap smear results within five years of enrollment, and treatment with immunosuppressive drugs. Pap smear results were categorized as normal or abnormal including atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LGSIL), and high-grade squamous intraepithelial lesion (HGSIL). RESULTS: The median age at the time of Pap smear was 46 (range: 17-74) years for the IBD group and matched controls (range: 19-72 years). There were more Caucasian subjects than other ethnicities in the IBD patient group (P = 0.025), as well as fewer abortions (P = 0.008), but there was no significant difference regarding marital status. Eighteen percent of IBD patients had abnormal Pap smears compared to 5% of controls (P = 0.004). Subgroup analysis of the IBD patients revealed no significant differences between CD and UC patients in age, ethnicity, marital status, number of abortions, disease severity, family history of IBD, or disease duration. No significant difference was observedin the number of abnormal Pap smears or the use of immunosuppressive medications between CD and UC patients (P = 0.793). No definitive observation could be made regarding HPV status, as this was not routinely investigated during the timeframe of our study. CONCLUSION: Diagnosis of IBD in women is related to an increased risk of abnormal Pap smear, while type of IBD and exposure to immunosuppressive medications are not. This has significant implications for women with IBD in that Pap smear screening protocols should be conscientiously followed, with appropriate investigation of abnormal results. | Jyoti Bhatia Jason Bratcher Burton Korelitz Katherine Vakher Shlomo Mannor Maria Shevchuk Gworgia Panagopoulos Adam Ofer Ecaterina Tamas Panayota Kotsali Oana Vele | 2006 | World Journal of Gastroenterology2006，12，38： | 3 |
| 5 | Impacts of climate change on hydrology,water quality and crop productivity in the Ohio-Tennessee River Basin显示文摘Nonpoint source pollution from agriculture is the main source of nitrogen and phosphorus in the stream systems of the Corn Belt region in the Midwestern US.The eastern part of this region is comprised of the Ohio-Tennessee River Basin(OTRB),which is considered a key contributing area for water pollution and the Northern Gulf of Mexico hypoxic zone.A point of crucial importance in this basin is therefore how intensive corn-based cropping systems for food and fuel production can be sustainable and coexist with a healthy water environment,not only under existing climate but also under climate change conditions in the future.To address this issue,a OTRB integrated modeling system has been built with a greatly refined 12-digit subbasin structure based on the Soil and Water Assessment Tool(SWAT)water quality model,which is capable of estimating landscape and in-stream water and pollutant yields in response to a wide array of alternative cropping and/or management strategies and climatic conditions.The effects of three agricultural management scenarios on crop production and pollutant loads exported from the crop land of the OTRB to streams and rivers were evaluated:(1)expansion of continuous corn across the entire basin,(2)adoption of no-till on all corn and soybean fields in the region,(3)implementation of a winter cover crop within the baseline rotations.The effects of each management scenario were evaluated both for current climate and projected mid-century(2046-2065)climates from seven global circulation models(GCMs).In both present and future climates each management scenario resulted in reduced erosion and nutrient loadings to surface water bodies compared to the baseline agricultural management,with cover crops causing the highest water pollution reduction.Corn and soybean yields in the region were negligibly influenced from the agricultural management scenarios.On the other hand,both water quality and crop yield numbers under climate change deviated considerably for all seven GCMs compared to the baseline climate.Future climates from all GCMs led to decreased corn and soybean yields by up to 20%on a mean annual basis,while water quality alterations were either positive or negative depending on the GCM.The study highlights the loss of productivity in the eastern Corn Belt under climate change,the need to consider a range of GCMs when assessing impacts of climate change,and the value of SWAT as a tool to analyze the effects of climate change on parameters of interest at the basin scale. | Yiannis Panagopoulos Philip W.Gassman Raymond W.Arritt Daryl E.Herzmann Todd D.Campbell Adriana Valcu Manoj K.Jha Catherine L.Kling Raghavan Srinivasan Michael White Jeffrey G.Arnold | 2015 | International Journal of Agricultural and Biological Engineering2015，8，3： | 2 |
| 6 | Extra- corporeal shock wave lithotripsy success based on body mass index and Hounsfield units显示文摘 | Pareek G Armenakas NA Panagopoulos G | 2005 | Urology2005，65，1： | 1 |
| 7 | Desgin of PI controllers based on non-convex optimization显示文摘 | Astrom K J Panagopoulos H Hagglund T | 1998 | Automatica1998，34，： | 1 |
| 8 | Treatment of ex- tracapsular hip fractures with the proximal femoral nail (PFN):long tern results in 45 patients显示文摘 | Tyllianakis M Panagopoulos A Papadopoulos A | 2004 | Acta Orthop Belg2004，70，5： | 1 |
| 9 | Application of MODFLOW for simulating groundwater flow in the Trifilia karst aquifer,Greece显示文摘 | Panagopoulos G | 2012 | Environmental Earth Sciences2012，67，： | 1 |
| 10 | Laser surface treatment of copper显示文摘 | C. Panagopoulos A. Michaelides | 1992 | Journal of Materials Science1992，，5： | 1 |
| 11 | Power allocation in cognitive satellite terrestrial networks with QoS constraints显示文摘 | Vassaki S Poulakis M I Panagopoulos A D | 2013 | IEEE Communications Letters2013，17，7： | 1 |
| 12 | Effect of microwave exposure on the ovarian development of Drosophila melanogaster显示文摘 | Panagopoulos D J | 2012 | Cell Biochem Biophys2012，63，2： | 1 |
| 13 | Complications in percutaneous nephrolithotomy 显示文摘 | KYRIAZIS I PANAGOPOULOS V KALLIDONIS P | 2015 | World J Urol2015，33，8： | 1 |
| 14 | clinical case of the month:myoclonic-astatic epilepsy in a young child(MAE) or Doose syndrome显示文摘 | Dubru JM Bricteux G Panagopoulos A | 2002 | Rev med liege2002，57，： | 1 |
| 15 | treatm ent of extracap- sular hip fractures with the proximal femoral najl (PFN) : long termrosults in 45 patients 显示文摘 | TyuiaIlianakis M Panagopoulos A | 2009 | Acta Orthop Belg2009，70，5： | 1 |
| 16 | Fournier's gangrene, a urologic and surgical emergency: presentation of a multi-institutional experience with 45 cases显示文摘 | Koukouras D Kallidonis P Panagopoulos C | 2011 | Urol Int2011，86，2： | 1 |
| 17 | A randomised comparison of AMBI,TGN and PFN for treatment of unstable trochanteric fractures显示文摘 | Papasimos S Koutsojannis CM Panagopoulos A | 2005 | Arch Orthop Trauma Surg2005，125，7： | 1 |
| 18 | Estimation of Nitrogen and Phosphorus Losses to Surface Water and Groundwater Through the Implementation of the SWAT Model for Norwegian Soils显示文摘 | Panagopoulos I Mimikou M Kapetanaki M | 2007 | J Soils Sediments2007，7，4： | 1 |
| 19 | A methylation PCR approach for detection of fragile X syndrome显示文摘 | Panagopoulos L Lassen C Kristoffersson U | 1999 | Hum Mutat1999，14，1： | 1 |
| 20 | Small target detection in sea clutter 显示文摘 | Panagopoulos S Soraghan J | 2004 | IEEE Trans on Geoscience and Remote Sensing2004，42，7： | 1 |
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