|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 2 | Solid-state fermentation for the production of Monascus pigments from jackfruit seed 显示文摘 | Babitha S Soccol C R Pandey A | 2007 | Bioresouree Technology2007，98，8： | 1 |
| 3 | Biotreatment of waste gas containing pyridine in a biofilter 显示文摘 | Pandey R A Padoley K V Mukherji S S | 2007 | Bioresource Technology2007，98，12： | 1 |
| 4 | Concentrations of heavy metals and aquatic macrophytes of Govind Ballabh Pant Sagar an anthropogenic lake affected by coal mining effluent显示文摘 | MISHRA V K UPADHYAY A R PANDEY S K | 2008 | Environmental Monitoring and Assessment2008，141，： | 1 |
| 5 | Central core myopathy with RYR1 mutation masks 5q spinal muscular atrophy显示文摘 | Pandey R Chandratre S Roberts A | | 0，，： | 1 |
| 6 | Endovascular coil embolization of ruptured and unruptured posterior circulation aneurysms:review of a 10-year expemrience显示文摘 | PANDEY A S KOEBBE C ROSENWASSER R H | 2007 | Neurosurgery2007，60，4： | 1 |
| 7 | Solid-state fermentation for the production of Monascus pigments from jackfruit seed显示文摘 | BABITHA S SOCCOL C R PANDEY A | 2007 | Bioresource Technology2007，98，8： | 1 |
| 8 | Biochemical and hormonal characterization of follicles from follicular and luteal phase ovaries of goat and sheep显示文摘 | SINGH D SHARMA M K PANDEY R S | 1999 | Indian J Exp Biol1999，37，5： | 1 |
| 9 | Nanoencapsulation of azole antifungals:potential applications to improve oral drug delivery显示文摘 | Pandey R Ahmad Z Sharma S | 2005 | International Journal of Clinical Pharmacy2005，301，12： | 1 |
| 10 | An update in recurrent spontaneous abortion显示文摘 | Pandey MK Rani R Agrawal S | 2005 | Arch Gynecol Obstet2005，272，2： | 1 |
| 11 | Decomposition of fine roots of Pinus kesiya and turnover of organic matter,N and P of coarse and fine pine roots and herbaceous roots and rhizomes in subtropical pine forests stands of different ages 显示文摘 | John B Pandey H N Tripathi R S | 2002 | Biology and Fertility of Soils2002，35，4： | 1 |
| 12 | Membranes for gas separation显示文摘 | Chauhan R S | 2001 | Prog Polym Sci2001，26，6： | 1 |
| 13 | Genotoxicity evaluation of acute doses of endosulfan to freshwater teleost Channa punctatus (Bloch) by alkaline single- cell gel electrophoresis显示文摘 | Pandey S Nagpure N S Kumar R | 2006 | Eeotoxicol Environ Safety2006，65，2： | 1 |
| 14 | Nitrogen mineralization and microbial biomass-Nina subtropical humidfores to Meghalaya显示文摘 | Das A K Tripath R S Pandey H N | 1997 | India Soil Boil Biochem1997，29，： | 1 |
| 15 | Strain induced fracture in low strength steels显示文摘 | PANDEY R K BANJEREE S | 1978 | Engineering Fracture Mechanics1978，10，4： | 1 |
| 16 | Litterfall, litter decomposition and nutrient dynamics in a subtropical natural oak forest and managed plantation in northeastern India显示文摘 | PANDEY R R SHARMA G TRIPATHI S K | 2007 | Forestry Ecology and Management2007，240，： | 1 |
| 17 | A greenhouse screening technique for acid soil tolerance in maize显示文摘 | Urrea-Gomez R Ceballos H Pandey S Bahia-Filho A F C Leon L A | 1996 | Agron J1996，88，： | 1 |
| 18 | Energy and Exergy Analysis of Typical Renewable Energy Systems 显示文摘 | PARK S R PANDEY A K TYAGI V V | 2014 | Renewable and Sustainable Energy Reviews2014，30，2： | 1 |
| 19 | The realm of mi- crobial lipases in biotechnology显示文摘 | Pandey A Benjamin S Soeeol C R | 1999 | Biotechnol Appl Bio- chem1999，，29： | 1 |
| 20 | Self-assembled gemini surfactant film-mediateddispersion stability显示文摘 | Rabinovich Y I Kanicky J R Pandey S | 2005 | Journal of Colloid and Interface Science2005，288，58： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员