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| 1 | Role of oxidative stress in endothelial insulin resistance显示文摘The International Diabetes Federation estimates that 316million people are currently affected by impaired glucose tolerance(IGT).Most importantly,recent forecasts anticipate a dramatic IGT increase with more that 470million people affected by the year 2035.Impaired insulin sensitivity is major feature of obesity and diabetes and is strongly linked with adverse cardiometabolic phenotypes.However,the etiologic pathway linking impaired glucose tolerance and cardiovascular disease remains to be deciphered.Although insulin resistance has been attributed to inflammatory programs starting in adipose tissue,emerging evidence indicates that endothelial dysfunction may represent the upstream event preceding peripheral impairment of insulin sensitivity.Indeed,suppression of reactive oxygen species-dependent pathways in the endothelium has shown to restore insulin delivery to peripheral organs by preserving nitric oxide(NO)availability.Here we describe emerging theories concerning endothelial insulin resistance,with particular emphasis on the role oxidative stress.Complex molecular circuits including endothelial nitric oxide synthase,prostacyclin synthase,mitochondrial adaptor p66^(Shc),nicotinamide adenine dinucleotide phosphate-oxidase oxidase and nuclear factor kappa-B are discussed.Moreover,the review provides insights on the effectiveness of available compounds(i.e.,ruboxistaurin,sildenafil,endothelin receptor antagonists,NO donors)in restoring endothelial insulin signalling.Taken together,these aspects may significantly contribute to design novel therapeutic approaches to restore glucose homeostasis in patients with obesity and diabetes. | Francesco Paneni Sarah Costantino Francesco Cosentino | 2015 | World Journal of Diabetes2015，6，2： | 5 |
| 2 | Gene silencing of the mitochondrial adaptor p66(She)suppresses vascular hyperglycemic memory in diabetes显示文摘 | Paneni F Mocharla P Akhmedov A | 2012 | Circulation research2012，111，3： | 1 |
| 3 | Diabetes and Vascular Disease Pathophysiology,Clinical Conse- quences,and Medical Therapy:Part II显示文摘 | Beckman JA Paneni F Cosentino F | 2013 | Eur Heart J2013，34，31： | 1 |
| 4 | Gene silencing of the mitochondrial adaptor p66 (Shc) suppresses vascular hyperglycemic memory in diabetes显示文摘 | Paneni F Mocharla P Akhmedov A | 2012 | Circ Res2012，111，： | 1 |
| 5 | Role of the renin-angio-tensin-aldosterone system and inflammatory processes in the devel-opment and progression of diastolic dysfunction 显示文摘 | Sciarretta S Paneni F Palano F | 2009 | Clin Sci(Lond)2009，116，6： | 1 |
| 6 | Right ventricular dysfunction in patients with end-stage renal disease显示文摘 | Paneni F Gregori M Ciavarella GM | 2010 | Am J Nephrol2010，32，5： | 1 |
| 7 | Gene silencing of the mitochondrial adaptor p66 (Shc) suppresses vascular hyperglycemic memory in diabetes显示文摘 | Paneni F Mocharla P Akhmedov A | 2012 | Circ Res2012，111，3： | 1 |
| 8 | p66 ( Shc ) - induced redox changes drive endothelial insulin resistance 显示文摘 | Paneni F Costantino S Cosentino F | 2014 | Ath- erosclerosis2014，236，2： | 1 |
| 9 | Gene silencing of the mitochondrial adaptor p66 (Shc) suppresses vascular hyperglycemic memory in diabetes显示文摘 | Paneni F Mocharla P Akhmedov A | | 0，，： | 1 |
| 10 | Role of the renin - angiotensin - aldosterone system and inflammatory processes in the development and progression of diastolic dysfunction 显示文摘 | Sciarretta S Paneni F Palano F | 2009 | Clin Sci2009，116，6： | 1 |
| 11 | Insulin resistance, diabe- tes, and cardiovascular risk 显示文摘 | Paneni F Costantino S Cosentino F | 2014 | Curr Atheroscler Rep2014，16，7： | 1 |
| 12 | Diabetes and vascular disease:pathophysiology,clinical consequences,and medical therapy: part II 显示文摘 | Beckman JA Paneni F Cosentino F | 2013 | EurHeart J2013，34，31： | 1 |
| 13 | Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo显示文摘 | Akhmedov A Rozenberg I Paneni F | 2014 | Eur Heart J2014，35，40： | 1 |
| 14 | Diabetes and vascular disease: pathophysiology, clinical consequences l and medical therapy: part I显示文摘 | Paneni F Beckman JA Creager MA | 2013 | Eur Heart J2013，34，31： | 1 |
| 15 | Role of the rennin - angiotensin - aldosterone system and inflammatory processes in the development and progression of diastolic dysfunction 显示文摘 | Sciarretta S Paneni F Palano F | 2009 | Clin Sci ( Lond )2009，116，6： | 1 |
| 16 | Diabetes and vascular disease : pathophysiology, clinical consequences, and medical therapy: part I显示文摘 | Paneni F Beckman JA Creager MA | 2013 | Eur Heart J2013，34，31： | 1 |
| 17 | Role of the reninangiotensin- aldosterone system and inflammatory processes in the development and progression of diastolic dysfunction 显示文摘 | Sciarretta S Paneni F Palano F | 2009 | Clin Sci ( Lond )2009，116，6： | 1 |
| 18 | Left bundle-branch blockpathophysiology,prognosis,and clinical management显示文摘 | Francia P Balla C Paneni F | 2007 | Clin Cardiol2007，30，3： | 1 |
| 19 | Diabetes and vascular dis- ease : pathophysiology, clinical consequences, and medical therapy : part I显示文摘 | Paneni F Beckman JA Creager MA | 2013 | European Heart Journal2013，34，31： | 1 |
| 20 | Right ventricular dysfunction in patients with end-stage renal disease显示文摘 | Paneni F Gregori M Ciavarella GM | 2010 | Am J Nephrol2010，32，： | 1 |
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