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| 1 | Polyethylene glycols: An effective strategy for limiting liver ischemia reperfusion injury显示文摘Liver ischemia-reperfusion injury(IRI) is an inherent feature of liver surgery and liver transplantation in which damage to a hypoxic organ(ischemia) is exacerbated following the return of oxygen delivery(reperfusion). IRI is a major cause of primary nonfunction after transplantation and may lead to graft rejection, regardless of immunological considerations. The immediate response involves the disruption of cellular mitochondrial oxidative phosphorylation and the accumulation of metabolic intermediates during the ischemic period, and oxidative stress during blood flow restoration. Moreover, a complex cascade of inflammatory mediators is generated during reperfusion, contributing to the extension of the damage and finally to organ failure. A variety of pharmacological interventions(antioxidants, anticytokines, etc.) have been proposed to alleviate graft injury but their usefulness is limited by the local and specific action of the drugs and by their potential undesirable toxic effects. Polyethylene glycols(PEGs), which are non-toxic water-soluble compounds approved by the FDA, have been widely used as a vehicle or a base in food, cosmetics and pharmaceuticals, and also as adjuvants for ameliorating drug pharmacokinetics. Some PEGs are also currently used as additives in organ preservation solutions prior to transplantation in order to limit the damage associated with cold ischemia reperfusion. More recently, the administration of PEGs of different molecular weights by intravenous injection has emerged as a new therapeutic tool to protect liver grafts from IRI. In this review, we summarize the current knowledge concerning the use of PEGs as a useful target for limiting liver IRI. | Gianfranco Pasut Arnau Panisello Emma Folch-Puy Alexandre Lopez Carlos Castro-Benítez Maria Calvo Teresa Carbonell Agustín García-Gil RenéAdam Joan Roselló-Catafau | 2016 | World Journal of Gastroenterology2016，22，28： | 3 |
| 2 | Towards the implementation of HACCP; results of a UK regional survey显示文摘 | Panisello P J Quantick P C Knowles M J | 1999 | Food Control1999，10，： | 1 |
| 3 | Preparation and characterization of polysulfone microcapsules for perfume release 显示文摘 | Pena B Panisello C Arest6 G | 2012 | Chemical Engineering Journal2012，179，： | 1 |
| 4 | Technical barriers to Hazard Analysis Critical Control Point (HACCP)显示文摘 | Panisello P J Quantick P C | 2001 | Food Control2001，12，： | 1 |
| 5 | Protective Effect of Intravenous High Molecular Weight Polyethylene Glycol on Fatty Liver Preservation显示文摘 | Mohamed Bejaoui Eirini Pantazi Emma Folch-Puy Arnau Panisello María Calvo Gianfranco Pasut Antoni Rimola Miquel Navasa René Adam Joan Roselló-Catafau Hartmut Jaeschke | 2015 | BioMed Research International2015，，： | 1 |
| 6 | Application of foodborne disease outbreak data in the development and maintenance of HACCP systems显示文摘 | Panisello P J Rooney R Quantick P C | 2000 | Int J Food Microbiol2000，59，3： | 1 |
| 7 | Technical barriers to Hazard Analysis Critical Control Point (HACCP)显示文摘 | Pedro Javier Panisello Peter Charles Quantick | 2001 | Food Control2001，，3： | 1 |
| 8 | Polysulfone Micro- capsules with Different Wall Morphology显示文摘 | Panisello C Pena B Gumi T | 2013 | Journal of Applied Polymer Science2013，129，： | 1 |
| 9 | Towards the implementation of HACCP: results of a UK regional survey显示文摘 | Pedro Javier Panisello Peter Charles Quantick Michael John Knowles | 1999 | Food Control1999，，2： | 1 |
| 10 | Application of foodborne disease outbreak data in the development and maintenance of HACCP systems 显示文摘 | PANISELLO PJ ROONEY R QUANTICK PC | 2000 | Int Food Mierobiol2000，，59： | 1 |
| 11 | Application of food micromodel predictive software in the development of Hazard Analysis Critical Control Point (HACCP) sys- tems 显示文摘 | PANISELLO P J QUANTICK P C | 1998 | Food Microbiology1998，15，4： | 1 |
| 12 | Capillary supply, fibre types and fibre morphometry in rat tibialis anterior and diaphragm muscles after intermittent exposure to hypobaric hypoxia显示文摘 | Panisello P Torrella J R Esteva S | 2008 | Eur J Appl Physiol2008，103，2： | 1 |
| 13 | Enzyme activity and myoglobin concentration in rat myocardium and skeletal muscles after passive intermittent simulated altitude exposure 显示文摘 | Esteva S Panisello P Ramon T J | 2009 | J Sports Sci2009，27，6： | 1 |
| 14 | Technical barriers to Hazard Analysis Critical Control Point (HACCP)显示文摘 | Panisello P J Quantick P C | 2001 | Food control2001，12，： | 1 |
| 15 | Technical barriers to Hazard Analysis Critical Control Point (HACCP)显示文摘 | Pedro Javier Panisello Peter Charles Quantick | 2001 | Food Control2001，，3： | 1 |
| 16 | Application of food micromodel predictive software in the development of hazard analysis critical control point (HACCP) systems显示文摘 | PANISELLO P J QUANTICK P C | 1998 | Food Microbiology1998，15，4： | 1 |
| 17 | Complication of an insufficiency fracture of the acetabulum显示文摘 | Angles F Coscujuela A Tramunt C Panisello MG Portabella F | 2008 | Hip Int2008，18，3： | 1 |
| 18 | Application of Food MicroModel predictive software in the development of Hazard Analysis Critical Control Point (HACCP) systems显示文摘 | PANISELLO P J QUANTICK P C | 1998 | Food Microbiology1998，15，4： | 1 |
| 19 | Noninvasive ventilation in pediatric intensive care 显示文摘 | Marohn K Panisello JM | 2013 | C urr Opin Pediat2013，25，3： | 1 |
| 20 | Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation显示文摘AIM: To investigate a possible association between losartan and sirtuin 1(SIRT1) in reduced-size orthotopic liver transplantation(ROLT) in rats.METHODS: Livers of male Sprague-Dawley rats(200-250 g) were preserved in University of Wisconsin preservation solution for 1 h at 4 ℃ prior to ROLT.In an additional group,an antagonist of angiotensin Ⅱ type 1 receptor(AT1R),losartan,was orally administered(5 mg/kg) 24 h and 1 h before the surgical procedure to both the donors and the recipients.Transaminase(as an indicator of liver injury),SIRT1 activity,and nicotinamide adenine dinucleotide(NAD+,a co-factor necessary for SIRT1 activity) levels were determined by biochemical methods.Protein expression of SIRT1,acetylated Fox O1(ac-Fox O1),NAMPT(the precursor of NAD+),heat shock proteins(HSP70,HO-1) expression,endoplasmic reticulum stress(GRP78,IRE1 a,p-e IF2) and apoptosis(caspase 12 and caspase 3) parameters were determined by Western blot.Possible alterations in protein expression of mitogen activated protein kinases(MAPK),such as p-p38 and p-ERK,were also evaluated.Furthermore,the SIRT3 protein expression and m RNA levels were examined.RESULTS: The present study demonstrated that losartan administration led to diminished liver injury when compared to ROLT group,as evidenced by the significant decreases in alanine aminotransferase(358.3 ± 133.44 vs 206 ± 33.61,P < 0.05) and aspartate aminotransferase levels(893.57 ± 397.69 vs 500.85 ± 118.07,P < 0.05).The lessened hepatic injury in case of losartan was associated with enhanced SIRT1 protein expression and activity(5.27 ± 0.32 vs 6.08 ± 0.30,P < 0.05).This was concomitant with increased levels of NAD+(0.87 ± 0.22 vs 1.195 ± 0.144,P < 0.05) the co-factor necessary for SIRT1 activity,as well as with decreases in ac-Fox O1 expression.Losartan treatment also provoked significant attenuation of endoplasmic reticulum stress parameters(GRP78,IRE1 a,p-e IF2) which was consistent with reduced levels of both caspase 12 and caspase 3.Furthermore,losartan administration stimulated HSP70 protein expression and attenuated HO-1 expression.However,no changes were observed in protein or m RNA expression of SIRT3.Finally,the protein expression pattern of p-ERK and p-p38 were not altered upon losartan administration.CONCLUSION: The present study reports that losartan induces SIRT1 expression and activity,and that it reduces hepatic injury in a ROLT model. | Eirini Pantazi Mohamed Bejaoui Mohamed Amine Zaouali Emma Folch-Puy Anabela Pinto Rolo Arnau Panisello Carlos Marques Palmeira Joan Roselló-Catafau | 2015 | World Journal of Gastroenterology2015，21，26： | 0 |
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