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| 1 | Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing显示文摘Diabetic ischemic wound treatment remains a critical clinical challenge.Neovascularization plays a significant role in wound healing during all stages of the tissue repair process.Strategies that enhance angiogenesis and neovascularization and improve ischemic pathology may promote the healing of poor wounds,particularly diabetic wounds in highly ischemic conditions.We previously identified a cyclic peptide LXW7 that specifically binds to integrinαvβ3 on endothelial progenitor cells(EPCs)and endothelial cells(ECs),activates vascular endothelial growth factor(VEGF)receptors,and promotes EC growth and maturation.In this study,we designed and synthesized a multi-functional pro-angiogenic molecule by grafting LXW7 and collagen-binding peptides(SILY)to a dermatan sulfate(DS)glycosaminoglycan backbone,named LXW7-DS-SILY,and further employed this multi-functional molecule to functionalize collagen-based extracellular matrix(ECM)scaffolds.We confirmed that LXW7-DS-SILY modification significantly promoted EPC attachment and growth on the ECM scaffolds in vitro and supported EPC survival in vivo in the ischemic environment.When applied in an established Zucker Diabetic Fatty(ZDF)rat ischemic skin flap model,LXW7-DS-SILY-functionalized ECM scaffolds loaded with EPCs significantly improved wound healing,enhanced neovascularization and modulated collagen fibrillogenesis in the ischemic environment.Altogether,this study provides a promising novel treatment to accelerate diabetic ischemic wound healing,thereby reducing limb amputation and mortality of diabetic patients. | Siqi He Tanaya Walimbe Hongyuan Chen Kewa Gao Priyadarsini Kumar Yifan Wei Dake Hao Ruiwu Liu Diana L.Farmer Kit S.Lam Jianda Zhou Alyssa Panitch Aijun Wang | 2022 | Bioactive Materials2022，7，4： | 2 |
| 2 | Physical matrices stabilized by enzymatically sensitive covalent crosslinks 显示文摘 | Seal B L Panitch A | 2006 | Acta Biomaterialia2006，，2： | 1 |
| 3 | Physical polymer matrices based on affinity interactions between peptides and polysaccharides 显示文摘 | Seal B L Panitch A | 2003 | Biomacromolecules2003，4，： | 1 |
| 4 | Evaluation of recurrent Pneumonia显示文摘 | Panitch Howard B | 2005 | Pediatr Infect Dis2005，24，3： | 1 |
| 5 | Glatiramer acetate after induction therapy with mitoxantrone in relapsing multiple sclerosis显示文摘 | Vollrner T Panitch H Bar-Or A | | 0，，05： | 1 |
| 6 | Bronchiolitis in infants显示文摘 | | 2001 | Curr Opin pediatr2001，13，3： | 1 |
| 7 | Evaluation of recurrent pneumonia显示文摘 | Panitch HB | 2005 | Pediatr Infect Dis J2005，24，3： | 1 |
| 8 | Accuracy of ul- trasound-guided intra-artieular injections in puinea pig kness显示文摘 | Vazquez-Portalatin N Breur GJ Panitch A | 2015 | Bone Joint Res2015，4，1： | 1 |
| 9 | 彻底的现代马克思显示文摘经济危机使人重新燃起了对卡尔·马克思的兴趣,《资本论》一书在全球热销(仅德国一家出版社的销量就从2007年的100本增加列了2008年的数千本),这也从另一面显示了此次危机波及范围之广、破坏力之大,使资本主义的信徒出现了意识形态紊乱。 | 利奥·帕尼奇(Leo Panitch) 何靓靓(译) | 2009 | 国外社会科学文摘2009，，10： | 1 |
| 10 | Thoroughly?Mod- em?Marx显示文摘 | Leo Panitch | 2009 | Foreign Policy2009，，： | 1 |
| 11 | Effects of NCPAP onlung mechanics in infants with acquired tracheobronchomalacia显示文摘 | Panitch HB Allen JL Alpert BE | 1994 | Am J Respir Crit Care Med1994，150，51： | 1 |
| 12 | Scaffold-free in vitro arterial mimetics: the importance of smooth muscle-endothelium contact 显示文摘 | Chaterji S Park K Panitch A | 2010 | Tissue Eng Part A2010，16，6： | 1 |
| 13 | Full results of the Evidence of Interferon Dose-Response-European North American Comparative Efficacy(EVIDENCE)study:a multicenter,randomized,assessorblinded comparison of low-dose weekly versus high-dose,highfrequency interferon beta-1a for relapsing mul显示文摘 | Schwid SR Panitch HS | | 0，，09： | 1 |
| 14 | Development of affini- ty-based delivery of NGF from a chondroitin sulfate biomaterial显示文摘 | Butterfield KC Conovaloff AW Panitch A | 2011 | Biomatter2011，1，2： | 1 |
| 15 | Long-term slowing of disability progression in patients receiving continuous glatiramer acetate compared with those withdrawing from therapy:10 year results from an ongoing trial显示文摘 | JOHNSON KP PANITCH HS FORD CC | 2004 | Neurology2004，62，75： | 1 |
| 16 | Additive effects of copolymer-1 and interferon beta-1b on the immune response to myelin basic protein显示文摘 | MILO R PANITCH H | 1995 | J Neuroimmunol1995，61，2： | 1 |
| 17 | Evaluation of recurrent pneumonia显示文摘 | Panitch HB | 2005 | Pediatr Infect Dis J2005，24，3： | 1 |
| 18 | Polymeric biomaterials for tissue and organ regeneration显示文摘 | Seal BL Otero TC Panitch A | 2001 | Mat Sci Eng2001，34，： | 1 |
| 19 | Long-term slowing of disability progression in patients receiving continuous glatiramer acetate compared with those withdrawing from therapy : 10 year resuhe from an ongoing trial显示文摘 | Johnson KP Panitch HS Ford CC | 2004 | Neurology2004，62，5： | 1 |
| 20 | Glatiramer acetate after induc- tion therapy with mitoxantrone in relapsing multiple sclerosis显示文摘 | Vollmer T Panitch H BarOr A | 2008 | Multiple Sclerosis2008，14，5： | 1 |
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