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| 1 | Multi-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen显示文摘According to the World Health Organization(WHO),oxidative stress(OS)is a significant contributor to male infertility.SeminalOS can be measured by a number of assays,all of which are either costly or time sensitive and/or require large semen volume andcomplex instrumentation.One less expensive alternative is to quantify the oxidation-reduction potential(ORP)with the MiOXSYS.In this international multi-center study,we assessed whether ORP levels measured by the MiOXSYS could distinguish semensamples that fall within the 2010 WHO normal reference values from those that do not.Semen samples were collected from 2092patients in 9 countries;ORP was normalized to sperm concentration(mV/10^6 sperm/ml).Only those samples with a concentration>1×10^6 sperm ml1 were in eluded.The results showed that 199 samples fell within the WHO no rmal refere nee range while theremaining 1893 samples did not meet one or more of the criteria.ORP was negatively correlated with all semen parameters(P <0.01)except volume.The area under the curve for ORP was 0.765.The ORP cut-off value(1.34 mV/10^6 sperm/ml)was able todifferentiate specimens with abnormal semen parameters with 98.1%sensitivity,40.6%specificity,94.7%positive predictivevalue(PPV)and 66.6%negative predictive value(NPV).When used as an adjunct to traditional semen analysis,ORP levels mayhelp identify altered functional status of spermatozoa caused by OS in cases of idiopathic male infertility and in male partners ofcouples sufferi ng recurre nt pregna ncy loss,and thereby directi ng these men to relevant medical therapies and lifestyle modificati ons. | Ashok Agarwal Manesh Kumar Panner Selvam Mohamed Arafa Hiroshi Okada Sheryl Homa Aideen Killeen Basak Balaban Ramadan Saleh Abdullah Armagan Shubhadeep Roychoudhury Suresh Sikka | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 2 | Molecular genetics of essential hypertension:recent results and emerging strategies 显示文摘 | Timberlake DS OConnor DT Panner RJ | 2001 | Curr Opin Nephrol Hypertens2001，10，1： | 1 |
| 3 | Industrial application for inline material sorting using hyperspectral imaging in the NIR range显示文摘 | Petra Tatzer Markus Wolf Thomas Panner | 2005 | Real-Time Imaging2005，，11： | 1 |
| 4 | P1 ( 3 ) kinase is associ- ated immtmo resistanee in breast and prostate cancer 显示文摘 | Crane CA Panner A Murray JC | 2009 | On cogene2009，28，2： | 1 |
| 5 | Use of APO2L/TRAIL with mTOR inhibitors in the treatment of glioblastoma multiforme显示文摘 | Panner A Parsa AT Pieper RO | 2006 | Exp Rev Anticancer Ther2006，6，9： | 1 |
| 6 | mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma muhiforme cells显示文摘 | Panner A James CD Berger MS | 2005 | Mol Cell Biol2005，25，20： | 1 |
| 7 | Honokiol-mediated inhibition of PI3 K/roTOR pathway:a potential strategy to overcome in glioma,breast,and prostate carcinoma without impacting T cell func- tion显示文摘 | Crane C Panner A Pieper RO | 2009 | J Immunother2009，32，6： | 1 |
| 8 | Loss of tumor suppressor PTEN function increases B7 - H1 expression and immunoresistance in glioma 显示文摘 | Parsa AT Waldron JS Panner A | 2007 | Nat Med2007，13，1： | 1 |
| 9 | PI(3)kinase is associated with a mechanism of immunoresistance in breast and prostate cancer显示文摘 | Crane C A Panner A Murray J C | 2009 | Oncogene2009，28，2： | 1 |
| 10 | PI3 kinase is associ- ated with a mechanism of immunoresistance in breast and prostate cancer 显示文摘 | Crane CA Panner A Murray JC | 2009 | Oneogenel2009，28，2： | 1 |
| 11 | Toxicity of radium cyanurate显示文摘 | Hodge HC Panner BJ Downs WI | | Toxicol Appl Pharmacol 196 50，7，5： | 1 |
| 12 | Constituents of the yew trees 显示文摘 | Panner V S Jha A Bish K S | 1999 | Phytochernistry1999，50，8： | 1 |
| 13 | Loss of tumor suppressor PTEN function increases B7-Hl expression and immunoresistance in g!ioma显示文摘 | Parsa AT Waldron JS Panner A | 2007 | Nat Med2007，13，1： | 1 |
| 14 | Spontaneous ignition in storage and pro- duction lines: investigation on wood pellets and protein powders 显示文摘 | Panner M A Bygbjerg H | 2007 | Fire and Materials2007，31，8： | 1 |
| 15 | Constituents of the yew trees 显示文摘 | Panner V S Jha A Bish K S | 1999 | Phytochemistry1999，50，8： | 1 |
| 16 | Proteomic analysis of seminal plasma from bilateral varicocele patients indicates an oxidative state and increased inflammatory response显示文摘Seminal plasma is a rich source of proteins and serves as an ideal sample for proteomic analysis of male infertility.In varicoceleassociated in fertility,the contributory role of semi nal plasma proteins specific to un ilateral and bilateral varicocele is not clear.Furthermore,there is a lack of specific protein biomarker to differentiate bilateral from unilateral varicocele.The main objective is to identify the differentially regulated molecular and cellular pathways in bilateral varicocele?Furthermore,we intend to identify seminal plasma biomarkers to differentiate bilateral and unilateral varicocele patients in comparison with fertile healthy men.Global proteomic an alysis of seminal plasma protei ns has identified the function ality of d iff ere ntially expressed proteins(DEPs)in varicocele patients.Bioinformatic analysis has revealed response to reactive oxygen species and oxidative stress,and tissue homeostasis as top process pathways that are affected in bilateral varicocele patients compared to fertile healthy men.In comparison with unilateral varicocele patients,inflammatory response pathways were dysregulated,especially interleukin 6(IL-6)signaling and Janus kinasesignal transducer and activator of transcription(Jak?STAT)pathways,in bilateral varicocele patients,owing to the involvement of underexpressed DEPs.Key DEPs associated with oxidative stress(peroxiredoxin 2;PRDX2),DNA fragmentation(fatty acid synthase;FASN),and inflammatory resp onse(fibr on ectin 1;FN1)validated by western blot analysis revealed differential expressi on of these proteins in unilateral and bilateral varicocele groups.Altered expression of DEPs and its association with key processes show that the seminal plasma homeostasis is compromised in bilateral varicocele patients?Furthermore,we propose PRDX2,FASN,and FN1 as potential noninvasive seminal plasma markers for the differentiation of unilateral and bilateral varicocele patients. | Manesh Kumar Panner Selvam Ashok Agarwal Saradha Baskaran | 2019 | Asian Journal of Andrology2019，21，6： | 1 |
| 17 | Ubiquitin-specifie protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPs stability and TRAIL sensitivity in glioblastoma multiforme显示文摘 | Panner A Crane CA Weng C | | 0，，12： | 1 |
| 18 | Honokiol-mediated inhibition of PI3K/mTOR pathway= a potential strategy to over- come immunoresistance in glloma, breast, and prostate carcino- ma without impacting T cell function显示文摘 | Crane C Panner A Pieper R O | 2009 | J Immunother2009，32，： | 1 |
| 19 | mTOR-inde-pendent translational control of the extrinsic cell death pathway by RalA显示文摘 | Panner A Nakamura JL Parsa AT | 2006 | Mol Cell Biol2006，26，20： | 1 |
| 20 | Translational regulation of TRAIL sensitivity 显示文摘 | Panner A Parsa A T Pieper RO | 2006 | Cell Cycle2006，5，2： | 1 |
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