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您的检索式：作者名="Panner Selvam"
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| 1 | Multi-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen显示文摘According to the World Health Organization(WHO),oxidative stress(OS)is a significant contributor to male infertility.SeminalOS can be measured by a number of assays,all of which are either costly or time sensitive and/or require large semen volume andcomplex instrumentation.One less expensive alternative is to quantify the oxidation-reduction potential(ORP)with the MiOXSYS.In this international multi-center study,we assessed whether ORP levels measured by the MiOXSYS could distinguish semensamples that fall within the 2010 WHO normal reference values from those that do not.Semen samples were collected from 2092patients in 9 countries;ORP was normalized to sperm concentration(mV/10^6 sperm/ml).Only those samples with a concentration>1×10^6 sperm ml1 were in eluded.The results showed that 199 samples fell within the WHO no rmal refere nee range while theremaining 1893 samples did not meet one or more of the criteria.ORP was negatively correlated with all semen parameters(P <0.01)except volume.The area under the curve for ORP was 0.765.The ORP cut-off value(1.34 mV/10^6 sperm/ml)was able todifferentiate specimens with abnormal semen parameters with 98.1%sensitivity,40.6%specificity,94.7%positive predictivevalue(PPV)and 66.6%negative predictive value(NPV).When used as an adjunct to traditional semen analysis,ORP levels mayhelp identify altered functional status of spermatozoa caused by OS in cases of idiopathic male infertility and in male partners ofcouples sufferi ng recurre nt pregna ncy loss,and thereby directi ng these men to relevant medical therapies and lifestyle modificati ons. | Ashok Agarwal Manesh Kumar Panner Selvam Mohamed Arafa Hiroshi Okada Sheryl Homa Aideen Killeen Basak Balaban Ramadan Saleh Abdullah Armagan Shubhadeep Roychoudhury Suresh Sikka | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 2 | Proteomic analysis of seminal plasma from bilateral varicocele patients indicates an oxidative state and increased inflammatory response显示文摘Seminal plasma is a rich source of proteins and serves as an ideal sample for proteomic analysis of male infertility.In varicoceleassociated in fertility,the contributory role of semi nal plasma proteins specific to un ilateral and bilateral varicocele is not clear.Furthermore,there is a lack of specific protein biomarker to differentiate bilateral from unilateral varicocele.The main objective is to identify the differentially regulated molecular and cellular pathways in bilateral varicocele?Furthermore,we intend to identify seminal plasma biomarkers to differentiate bilateral and unilateral varicocele patients in comparison with fertile healthy men.Global proteomic an alysis of seminal plasma protei ns has identified the function ality of d iff ere ntially expressed proteins(DEPs)in varicocele patients.Bioinformatic analysis has revealed response to reactive oxygen species and oxidative stress,and tissue homeostasis as top process pathways that are affected in bilateral varicocele patients compared to fertile healthy men.In comparison with unilateral varicocele patients,inflammatory response pathways were dysregulated,especially interleukin 6(IL-6)signaling and Janus kinasesignal transducer and activator of transcription(Jak?STAT)pathways,in bilateral varicocele patients,owing to the involvement of underexpressed DEPs.Key DEPs associated with oxidative stress(peroxiredoxin 2;PRDX2),DNA fragmentation(fatty acid synthase;FASN),and inflammatory resp onse(fibr on ectin 1;FN1)validated by western blot analysis revealed differential expressi on of these proteins in unilateral and bilateral varicocele groups.Altered expression of DEPs and its association with key processes show that the seminal plasma homeostasis is compromised in bilateral varicocele patients?Furthermore,we propose PRDX2,FASN,and FN1 as potential noninvasive seminal plasma markers for the differentiation of unilateral and bilateral varicocele patients. | Manesh Kumar Panner Selvam Ashok Agarwal Saradha Baskaran | 2019 | Asian Journal of Andrology2019，21，6： | 1 |
| 3 | Maternal and burial environment determine the physical dormancy release in tropical Senna auriculata(Fabaceae) seeds显示文摘In tropical ecosystems,species with an impermeable seed coat,i.e.physical dormancy(PY),are large in number and their seed coat is considered to be an adaptive trait for species persistence and colonization.However,only little is known about their mechanisms for breaking dormancy.The objective of this study was to understand the importance of seed maturation site and burial location in determining the PY release of Senna auriculata.Freshly collected seeds of S.auriculata from Vellore and Coimbatore,Tamil Nadu,India,germinated to 11±1.5%and19±2.5%respectively and remaining seeds did not imbibe water,thus had PY.Germination of seeds from both sites following hot-water treatment for 30 s and mechanical scarification increased significantly and seeds were able to germinate at a wide-range of temperatures(5–35℃)both in light and darkness.When incubated at 15/60℃for 3 months,dormancy release for seeds collected from Coimbatore(72%)was greater than seeds matured in Vellore(53%).Following 1 year of burial at three different locations,seeds from Coimbatore germinated to higher percentage than Vellore seeds at all locations.In particular,the higher temperature sites released dormancy to greater extent than the lower temperature site.Our results suggest that summer temperatures(>60℃)prevailing in the tropics provide appropriate cues for breaking PY,but this could be greatly affected by the initial state of seeds and the burial environment. | Ganesh K.Jaganathan Yingying Han Danping Song Panner Selvam Baolin Liu | 2019 | Journal of Forestry Research2019，30，4： | 0 |
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