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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | In vitro toxicity of trichothecene on human erythroblastic progenitors 显示文摘 | Rio B Lautraite S and parent - Massin D | 1997 | Hum Exp Toxicol1997，16，： | 2 |
| 3 | Rendering and animation of gaseous phenomena by combining fast volume and seanline a-buffer techniques 显示文摘 | EBERT D S PARENT R E | 1990 | Computer Graphics1990，94，4： | 1 |
| 4 | The association betweenScoliosis Research Society-22 scores and scoliosis severitychanges at a clinically relevant threshold显示文摘 | Parent EC Wong D Hill D | 2010 | Spine2010，35，3： | 1 |
| 5 | Improving the wear resis- tance of white cast iron using a new concept high-entropy microstructure显示文摘 | Wang Y P Li D Y Parent L | 2011 | Wear2011，271，910： | 1 |
| 6 | Knowledge creation in focus groups:can group technologies help显示文摘 | PARENT M GALLUPE R B SALISBURY W D | 2000 | Information & Management2000，38，1： | 1 |
| 7 | MRI signal distribution within the intcrvertcbral disc as a biomarker of adolescent idiopathic scoliosis and spondylolisthesis显示文摘 | Gervais J Pcrie D Parent S | 2012 | BMC Musculoskelet Disord2012，13，： | 1 |
| 8 | Layered construction for deformable animated characters 显示文摘 | Chadwick J E Haumann D R Parent R E | 1989 | ACM Siggraph Com- puter Gra-phics1989，23，3： | 1 |
| 9 | Relationship between isocratic and gradient times in the high-performance ionexchange graphy of proteins theory and experiment 显示文摘 | PARENTE E S WETLAUFER D B | 1986 | J Chromatogr1986，355，： | 1 |
| 10 | Postoperative delirium in inten?sive care patients: risk factors and outcome显示文摘 | Veiga D Luis C Parente D | 2012 | Rev Bras Aneste?siol2012，62，4： | 1 |
| 11 | High prevalence of detectable deep venous thrombosis in patients with acute pulmonary embolism显示文摘 | Girard P Musset D Parent F | 1999 | Chest1999，116，4： | 1 |
| 12 | Sulfuration and re- version reactions of brominated poly (isobutylene-co-isoprene) 显示文摘 | Parent J S White G D F Thorn D J | 2003 | Journal of Polymer Science ( part A ) : Polymer Chemistry2003，41，13： | 1 |
| 13 | 肺动脉高压启动治疗后血流动力学指标的预后价值显示文摘血流动力学指标,如心脏指数和右心房压力(right atrial pressure,RAP)与患者确诊肺动脉高压时的生存率持续相关。近期研究表明,肺动脉顺应性(pulmon aryarterial compliance,Pea)也可能预测肺动脉高压的预后。而在治疗开始之后测定的血流动力学指标对预后的价值还未确定。 | 黄洁 叶鹏 Weatherald J Boucly A Chemla D Savale L Peng M Jevnikar M Ja?s X Taniguchi Y O'Connell C Parent F Sattler C Hervé P Simonneau G Montani D Humbert M Adir Y Sitbon O | 2017 | 中华高血压杂志2017，25，11： | 1 |
| 14 | Postoperative delirium in intensive care patients:risk factors and outcome显示文摘 | Veiga D Luis C Parente D | | 0，，04： | 1 |
| 15 | Determinants of cross-national knowledge transfer and its effect on firm innovation显示文摘 | Kotabe M Dunlap-Hinkler D Parente R | 2007 | Journal of International Business Studies2007，38，： | 1 |
| 16 | Diagnostic strategy for patients with suspected pulmonary embolism:a prospective multicentre outcome study 显示文摘 | Musset D Parent F Meyer G | 2002 | Lancet2002，360，： | 1 |
| 17 | Evaluation of the microvasculature and cerebral ischemia after experimental suba- rachnoid hemorrhage in dogs 显示文摘 | PERKINS E KIMURA H PARENT A D | 2002 | J Neurosurg2002，97，4： | 1 |
| 18 | Identification of raspberry cultivars bynon-radioactive DNA fingerprinting显示文摘 | Parent J G Page D | 1992 | Hortic Sci1992，27，： | 1 |
| 19 | Rendering and animation of gaseous phenomena by combining fast volume and scanline a-buffer techniques显示文摘 | Ebert D S Parent R E | 1990 | Computer Graphics (SIGGRAPH 90 Conference Proceedings)1990，24，4： | 1 |
| 20 | Mechanism of ATP-inducedi mobilization in rat basilar smooth muscle cell显示文摘 | Aoki K Zubkov A Y Parent A D | 2000 | Stroke2000，31，： | 1 |
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