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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Identification of the role of presenilins beyond Alzheimer's disease显示文摘 | Thinakaran G Parent A T | 2004 | Pharmacol Res2004，50，4： | 1 |
| 3 | Potato response to crop sequence and nitrogen fertilization following sod breakup in a Gleyed Humo- Ferric Podzol显示文摘 | Li H L I~ Parent C T Karam A | 2009 | Can J Plant Sci2009，79，： | 1 |
| 4 | Modelling the coordination of the controls of stomatal aperture,transpiration,leaf growth,and abscisic acid:update and extension of the TardieuDavies model显示文摘 | TARDIEU F SIMONNEAU T PARENT B | 2015 | Journal of Experimental Botany2015，66，8： | 1 |
| 5 | Influence of specific energy on the properties of hydroentangled nonwoven pabrics 显示文摘 | Connolly T J Parent L R | 1993 | Nonwovens Conference1993，，1： | 1 |
| 6 | Neurophysiological field potent ial analysis by microcomputers显示文摘 | Mayhew W Parent A | 1982 | J of Neurosci Methods1982，5，： | 1 |
| 7 | Lumbar disc degeneration: epidemiology and genetic influences 显示文摘 | Battie MC Videman T Parent E | 2004 | Spine2004，29，23： | 1 |
| 8 | On spatial database integration显示文摘 | Devogele T Parent S C Spaccapietra | 1998 | International Journal of Geographical Information Systems1998，，12： | 1 |
| 9 | Lumbar disc degeneration:epidemiology and genetic influences显示文摘 | Battie MC Videman T Parent E | 2004 | Spine2004，29，14： | 1 |
| 10 | 显示文摘 | T G Gopakumar J A Lee M Kontopoulou J S Parent | 2002 | Polymer2002，43，： | 1 |
| 11 | On spatial Database intergration 显示文摘 | T DEVOGELE C PARENT S SPACCAPIETRA | 1998 | International Journal of Geograhica Information Science1998，，4： | 1 |
| 12 | Tropical pasture carbon cycling: relationships between C source/sink strength, aboveground biomass and grazing 显示文摘 | WILSEY B J PARENT G ROULET N T | 2002 | Ecology Letters2002，5，： | 1 |
| 13 | Hydrothermal dolomites in SW Sardinia(Italy):evidence for a widespread late-Variscan fluid flow event(in Paleofluid flow and diagenesis during basin evolution)显示文摘 | Boni M Parente G Bechstaedt T | 2000 | Sedimentary Geology2000，131，34： | 1 |
| 14 | Deformation of the pelvic floor muscles during a vaginal delivery显示文摘 | Parente M P Jorge R M Mascarenhas T | 2008 | Int Urogynecol J Pelvic Floor Dysfunct2008，19，1： | 1 |
| 15 | Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells显示文摘 | Meguro T Chen B Parent AD | 2001 | Stroke2001，32，2： | 1 |
| 16 | Lumbar disc degeneration:epidemiology and genetic influences显示文摘 | Battié MC Videman T Parent E | 2004 | Spine(Phila Pa 1976)2004，29，23： | 1 |
| 17 | Respective contributions of Arabidopsis DCL2 and DCL4 to RNA silencing显示文摘 | Parent J Bouteiller N Elmayan T | 2015 | The Plant Journal2015，81，2： | 1 |
| 18 | Site-specific phosphorylation of I kappa Balpha by a novel ubiquitination-dependent protein in kinase activity显示文摘 | Chen ZJ Parent I Maniatis T | 1996 | Cell1996，84，6： | 1 |
| 19 | Lumbar disc degeneration: epidemiology and genetic influences 显示文摘 | Battie MC Videman T Parent E | 2004 | Spine2004，29，24： | 1 |
| 20 | The influence of an occipito-posterior malposition on the biomechanical behavior of the pelvic floor 显示文摘 | Parente MP Jorge RM Mascarenhas T | 2009 | Eur J Obstet Gynecol Reprod Biol2009，144，1： | 1 |
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