|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | In vitro toxicity of trichothecene on human erythroblastic progenitors 显示文摘 | Rio B Lautraite S and parent - Massin D | 1997 | Hum Exp Toxicol1997，16，： | 2 |
| 3 | Methane yield from switchgrass harvested at different stages of development in Eastern Canada显示文摘 | Daniel Massé Yan Gilbert Philippe Savoie Gilles Bélanger Gaétan Parent Daniel Babineau | 2010 | Bioresource Technology2010，，24： | 1 |
| 4 | Modelling the coordination of the controls of stomatal aperture,transpiration,leaf growth,and abscisic acid:update and extension of the TardieuDavies model显示文摘 | TARDIEU F SIMONNEAU T PARENT B | 2015 | Journal of Experimental Botany2015，66，8： | 1 |
| 5 | Knowledge creation in focus groups:can group technologies help显示文摘 | PARENT M GALLUPE R B SALISBURY W D | 2000 | Information & Management2000，38，1： | 1 |
| 6 | Germination responses of 64 wetland species in relation to seed size,minimum time to reproduetion and seedling relative growth rate显示文摘 | Shipley B Parent M | 1991 | Functional Ecology1991，，5： | 1 |
| 7 | Pedunculopontine nucleus in the squirrel monkey:cholinergic and glutamatergic projections to the substantia nigra显示文摘 | Parent A | 1994 | J Comp Neurol1994，344，2： | 1 |
| 8 | Relationship between isocratic and gradient times in the high-performance ionexchange graphy of proteins theory and experiment 显示文摘 | PARENTE E S WETLAUFER D B | 1986 | J Chromatogr1986，355，： | 1 |
| 9 | Advanced lung adenocarcinoma in an EGFR-positive patient treated with Erlotinib for 52 months显示文摘 | Ivone Gon?alves Inês Ladeira Ana Castro Ana Antunes Ana Barroso Bárbara Parente | 2013 | Respiratory Medicine Case Reports2013，，： | 1 |
| 10 | Numerical models for 2D free boundary analysis of groundwater in slopes stabilized by drain trenches显示文摘 | DACUNTO B PARENTE F URCIUOLI G | 2007 | Computers & Mathematics with Applications2007，53，10： | 1 |
| 11 | Motion control: computing the arc length of parametric curves显示文摘 | Guenter B Parent R | 1990 | IEEE Computer Graphics & Applications1990，10，3： | 1 |
| 12 | Knowledge creation in focus groups: can group technologies help?显示文摘 | Parent M Gallupe R B | 2000 | Information & Management2000，38，： | 1 |
| 13 | Validation of the Wilcox k-ω model for flows characteristic to hypersonic airbreathing propulsion显示文摘 | Parent B Sislian J P | 2004 | AIAA Journal2004，42，2： | 1 |
| 14 | Uterine synechiae显示文摘 | Parent B Barbot J Dubuisson J | 1988 | Encycl Med Chir Gynecol1988，，： | 1 |
| 15 | Task-dependent effects of the antidepressant/antipanic drug phenelzine on memory 显示文摘 | Parent M B Habib M K Baker G B | 1999 | Psychopharmacology1999，142，3： | 1 |
| 16 | Computing the arc length of parametric curves显示文摘 | GUENTER B PARENT R | 1990 | IEEE Computer Graphics & Applications1990，10，3： | 1 |
| 17 | Optimal duration of chemotherapy in non-small-cell lung cancer:multicenter,randomized,prospective clinical trial comparing 4 vs 6 cycles of carboplatin and gerncitabine显示文摘 | Barata F Parente B Teixeira E | | 0，，08： | 1 |
| 18 | When is a 'rock' an 'island' ? - another unilateral declaration defies 'norms' of international law 显示文摘 | DIAZ L DUBNER B H PARENT J | 2007 | Michigan State Journal of Interna- tional Law2007，15，3： | 1 |
| 19 | Se- lectivity of coagent-mediated polypropylene maleation 显示文摘 | SENGUPTA S S PARENT J S CHAUDHARY B I | 2009 | Polym Eng Sei2009，49，： | 1 |
| 20 | Giant magnetoresistance in Co-Ag granular films preparedby low-energy cluster beam deposition显示文摘 | Parent F Tuaillon J Stern L B | 1997 | Phys Rev B1997，55，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员