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		题名	作者	年代	出处	被引量
	1	外用粒细胞集落刺激因子治疗Behet病患者的口腔和生殖器溃疡显示文摘Background: Recurrent and painful ulcers of the oral mucosa and genital skin/mucosa are the most commonly observedmanifestations in patients with disease (BD). They affect patients’quality of life. Because of the effectiveness of granulocyte colony-stimulating factor (G-CSF) in wound healing, it may also be useful for the treatment of oral ulcers (OU) and genital ulcers (GU) of BD. Objective: We aimed to determine the efficacy of topically applied G-CSF in the treatment of OU and GU of BD. Methods: Seven patients with BD diagnosed according to the criteria of the International Study Group for Disease were involved in the study. The patients were observed for 3months before the study,and all occurrences were recorded during this period. Patients were given topical G-CSF for OU (4 ×120 μg/day, for 5 days) and/or GU (4 ×30 μg/day, for 5 days) and followed-up for 3 months after treatment. No concurrent disease-specific or immunosuppressive topical or systemic drugs were given during the study period. Results: G-CSF treatment decreased the healing time and pain of OU and GU in six of seven patients comparedwith the pretreatment period. However, the effectiveness of the G-CSF treatment on OU and GU healing time and pain severity did not continue during the post-treatment period. Conclusions: G-CSF has beneficial effects on the healing duration and pain severity of OU and GU of patients with BD. However, given the high cost, impractical preparation and inability to cure the disease, G-CSF treatment should be chosen only in selected patients.	Bacanli A. Yerebakan Dicle O. Parmaksizoglu B. E. Yilmaz 李政霄	2006	世界核心医学期刊文摘(皮肤病学分册)2006，，12：	0

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