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| 1 | 用熔解曲线法分析插入/缺失多态性和Y染色体SNPs多态性显示文摘随着单核苷酸多态性SNPs (SingleNucleotidePolymorphisms)及插入 /缺失多态性Indels (Insertion/Dele tion)的分型技术研究的深入 ,SNPs和Indels在法医学上的应用将受到深刻的影响。本文研究和探讨Indels的分型方法 ,通过测定扩增DNA片段在溶液中的溶解曲线图确定每个样品的基因型 ,称为溶解曲线Indels基因分型方法(McI/D)。溶解曲线图由被测样品DNA片段的特殊溶解温度组成 ,扩增结果直接由仪器分析不需要繁杂的PCR后期操作。 | 叶健 郑秀芬 季安全 Esteban J Parra Donna M Sosnoski Mark D Shriver | 2001 | 中国法医学杂志2001，16，4： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 4 | A new class of folding oligomers: crescent oligoamides显示文摘 | Zhu J Parra R D Zeng H | 2000 | J Am Chem Soc2000，122，： | 1 |
| 5 | Mierowave - assisted regeneration of activated carbons loaded with phannaeeutieah 显示文摘 | C O Ania J B Parra J A Menendez | 2007 | water research2007，41，： | 1 |
| 6 | Strong ties,weak ties,and hu-man capital:latino immigrant employment outside the enclave显示文摘 | PFEFFER M J PARRA P A | 2009 | Rural Sociology2009，74，2： | 1 |
| 7 | The amino termi- nal sequence of VP60 from rabbit hemorrhagic disease virus supports its putative subgenomic origin显示文摘 | Parra F Boga J A Matin M S | 1993 | Vi- rus Res1993，27，3： | 1 |
| 8 | Injectable acrylic bone cements for vertebroplasty based on a radiopaque hydroxyapatite: bioactivity and biocompatibility显示文摘 | Hernandez L Parra J Viizquez B et a! | 2009 | J Mater Res2009，88，1： | 1 |
| 9 | Solar space heating and cooling for Spanish housing: potential energy savings and emissions reduction 显示文摘 | Marcos J D Izquierdo M Parra D | 2011 | Solar Energy2011，85，11： | 1 |
| 10 | PCR amplifica- tion of the Irish potato famine pathogen from historic specimens 显示文摘 | RISTAINO J B GROVES C T PARRA G R | 2001 | Nature2001，411，6838： | 1 |
| 11 | Effect of different cooking methods on lipid oxidation and formation of free cholesterol oxidation products (COPs) in Latissimus dorsi muscle of Iberian pigs显示文摘 | BRONCANO J M PETRON M J PARRA V | 2009 | Meat Science2009，83，3： | 1 |
| 12 | Sleep-related breath ing disorders: impact on mortality of cerebrovascular disease显示文摘 | Parra O Arboix A Montserrat J M | 2004 | EurRespirJ2004，24，26： | 1 |
| 13 | Kinetics of naphthalene adsorption on an activated carbon: comparison between aqueous and organic media 显示文摘 | Cabal B Ania C O Parra J B | 2009 | Chemosphere2009，74，4： | 1 |
| 14 | Use of proteases to improve oxidative stability of fermented sausages by increasing low molecular weight compounds with antioxidant activity 显示文摘 | Broncano J M Timon M L Parra V | 2011 | Food Research International2011，44，： | 1 |
| 15 | Lipid bilayers including cholesterol as vehicles for acid dyes in wool dyeing显示文摘 | De la Maza A Parra J L Manich A | 1993 | Textile Research Journal1993，63，11： | 1 |
| 16 | Xanthogranulomatous cholecystitis:clinical sonographic and CT findings in 26patients显示文摘 | Parra JA Acinas O Bueno J | 2000 | Am J Roentgenol2000，174，4： | 1 |
| 17 | Very high resolution interpolated climate surfaces for global land areas显示文摘 | Hijmans R J Cameron S E Parra J L | 2005 | International Journal of Climatology2005，25，15： | 1 |
| 18 | Analysis of bridge under multi - component random ground motion by response spectrum method 显示文摘 | G Parra - Montesinos J K Wight | 2003 | Journal of Structural Engineering2003，25，5： | 1 |
| 19 | Development of macro porosity inac- tivated carbons by effect of coal preoxidation and bum-off显示文摘 | Joes J P JOS B PARRA | 1998 | Fu- el1998，77，6： | 1 |
| 20 | Laparoscopic cysteetomy: initial report on a new treatment for the retained bladder 显示文摘 | Parra R O Andrus C H Jones J P | 1992 | J Urol1992，148，4： | 1 |
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