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| 1 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 2 | Phytase, Citric Acid and 1α- Hydroxycholecalciferol Improve Phytate Phosphorus Utilization in Chicks Feed Corn-soybean Meal Diet 显示文摘 | Snow J Baker D H Parsons C M | 2004 | Pouh Sci2004，83，： | 1 |
| 3 | CdZnTe and CdTe detector arrays for hard X-ray and gamma-ray astronomy 显示文摘 | Stahle C M Parker B H Parsons A M | 1999 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment1999，436，12： | 1 |
| 4 | Distillers dried grains with solubles as a protein source for the chick 显示文摘 | Parsons C M Baker D H Harter-Dennis J M | 1983 | Pouh Sci1983，62，： | 1 |
| 5 | Maintenance requirement for valine and efficiency of its use above maintenance for accretion of whole-body valine and protein in young chicks显示文摘 | Baker D H Femandez S R Parsons C M | 1996 | J Nutr1996，126，： | 1 |
| 6 | How well do radiographic, clinical and self - reported diagnoses of knee osteoarthritis agree? Findings from the Hertfordshire cohort study显示文摘 | Parsons C Clynes M Syddall H | 2015 | Springerplus2015，4，： | 1 |
| 7 | Development of a standardized approach to river habitat assessment in Australia显示文摘 | PARSONS M THOMS M C NORRIS R H | 2004 | Environment Monito-ring and Assessment2004，98，： | 1 |
| 8 | Amelioration of oral cop- per toxicity in chicks by dietary additions of ascorbic acid, cysteine and zinc显示文摘 | Persia M E Parsons C M Baker D H | 2003 | Nutrition Research2003，23，12： | 1 |
| 9 | Amino acid fortification of a low-protein corn and soybean meal diet for chicks 显示文摘 | Han Y M Suzuki H Parsons C M | 1992 | Poultry Science1992，71，： | 1 |
| 10 | PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer 显示文摘 | Li J Yen C Liaw D Podsypanina K Bose S Wang SI Puc J Miliaresis C Rodgers L McCombie R Bigner SH Giovanella BC Ittmann l Tycko B Hibshoosh H Wigler MH Parsons R | 1997 | Science1997，275，： | 1 |
| 11 | Phytase, citric acid, and lct-hydroxycholecaleiferol improve phytate phosphorus utili- zation in chicks fed a corn-soybean meal diet显示文摘 | Snow J L Baker D H Parsons C M | 2004 | Poultry Sci- ence2004，83，： | 1 |
| 12 | Bioaccumulation of polychlorinated dibenzopdioxins in sediment by oligochaetes:Influence of exposure pathway and contact time显示文摘 | Loonen H Muir D C G Parson J R | 1997 | Environmental Toxicology &Chemistry1997，16，： | 1 |
| 13 | Measurements of primary production in coastal sea waters using a large-volume plastic sphere显示文摘 | McAllister C D Parson K S Strickland J D H | 1961 | Limnol Oceanogr1961，6，： | 1 |
| 14 | Use of subtractive hybridization to identify a diagnostic probe for a cystic fibrnsis epidemic strain of Pseudomonas aeruginosa 显示文摘 | Parsons Y N Panagea S Smart C H | 2002 | J Clin Microbiol2002，40，12： | 1 |
| 15 | Citric acid improves phytate phosphorous utilization in crossbred and commericial broiler chicks显示文摘 | Rafaca L C Martinea A C M Parsons D H | 2005 | Pouh Sci2005，84，： | 1 |
| 16 | Amino acid fortification of a low- protein corn and soybean meal diet for chicks显示文摘 | Hart Y M Suzuki H Parsons C M | 1992 | Poult Sci1992，71，： | 1 |
| 17 | Effect of microbial phytase and citric acid on phosphorus bioanailability apparent metabolizable energy,and amino acid digestibility in distillers dried gried grains with solubles in chicks 显示文摘 | Martinez-Amezcua C Parsons C M Baker D H | 2006 | Poultry Science2006，85，： | 1 |
| 18 | Effect of microbial phytase and citric acid on phosphorous bioavailahility, apparent metabolizable energy and amino acid digestibility in distillers dried grains with solubles in chicks显示文摘 | Martinez-Amezcua C Parsons C M Baker D H | 2006 | Poultry science2006，85，： | 1 |
| 19 | Tracking the expression of excitatory, and inhibitot' neurotransmissicm-related proteins and neumplasticity markers '-after noise induced haring loss 显示文摘 | Browne C J Morley J W Parsons C H | 2012 | PLoSOne2012，7，3： | 1 |
| 20 | use of subtractive hy bridization to identify a diagnostic probe for cystic fibrosis epidemic strain of Pseudomonas a eruginosa显示文摘 | PARSON Y N PANGES S SMART C H | 2002 | J Clin Microbiol2002，40，12： | 1 |
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